MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects

Jenni E. Anttila; Olli S. Mattila; Hock-Kean Liew; Kert Mätlik; Eero Mervaala; Päivi Lindholm; Maria Lindahl; Perttu J. Lindsberg; Kuan-Yin Tseng; Mikko Airavaara

doi:10.1186/s40478-023-01701-y

MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects

Jenni E. Anttila
, Olli S. Mattila
, Hock-Kean Liew
, Kert Mätlik
, Eero Mervaala
, Päivi Lindholm
, Maria Lindahl
, Perttu J. Lindsberg
, Kuan-Yin Tseng
, Mikko Airavaara

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	10
Journal	Acta Neuropathologica Communications
Volume	12
Number of pages	24
ISSN	2051-5960
DOIs	https://doi.org/10.1186/s40478-023-01701-y
Publication status	Published - 16 Jan 2024
MoE publication type	A1 Journal article-refereed

Fields of Science

Distal middle cerebral artery occlusion
Inflammation
Ischemia
Mesencephalic astrocyte-derived neurotrophic factor
Neuroprotection
3112 Neurosciences

Access to Document

10.1186/s40478-023-01701-yLicence: CC BY

s40478-023-01701-yFinal published version, 2.86 MBLicence: CC BY

Cite this

Anttila, J. E., Mattila, O. S., Liew, H.-K., Mätlik, K., Mervaala, E., Lindholm, P., Lindahl, M., Lindsberg, P. J., Tseng, K.-Y., & Airavaara, M. (2024). MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects. Acta Neuropathologica Communications, 12, Article 10. https://doi.org/10.1186/s40478-023-01701-y

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title = "MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects",

keywords = "Distal middle cerebral artery occlusion, Inflammation, Ischemia, Mesencephalic astrocyte-derived neurotrophic factor, Neuroprotection, 3112 Neurosciences",

author = "Anttila, \{Jenni E.\} and Mattila, \{Olli S.\} and Hock-Kean Liew and Kert M{\"a}tlik and Eero Mervaala and P{\"a}ivi Lindholm and Maria Lindahl and Lindsberg, \{Perttu J.\} and Kuan-Yin Tseng and Mikko Airavaara",

year = "2024",

month = jan,

day = "16",

doi = "10.1186/s40478-023-01701-y",

language = "English",

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Anttila, JE, Mattila, OS, Liew, H-K, Mätlik, K, Mervaala, E , Lindholm, P , Lindahl, M , Lindsberg, PJ, Tseng, K-Y & Airavaara, M 2024, 'MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects', Acta Neuropathologica Communications, vol. 12, 10. https://doi.org/10.1186/s40478-023-01701-y

MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects. / Anttila, Jenni E.; Mattila, Olli S.; Liew, Hock-Kean et al.
In: Acta Neuropathologica Communications, Vol. 12, 10, 16.01.2024.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects

AU - Anttila, Jenni E.

AU - Mattila, Olli S.

AU - Liew, Hock-Kean

AU - Mätlik, Kert

AU - Mervaala, Eero

AU - Lindholm, Päivi

AU - Lindahl, Maria

AU - Lindsberg, Perttu J.

AU - Tseng, Kuan-Yin

AU - Airavaara, Mikko

PY - 2024/1/16

Y1 - 2024/1/16

KW - Distal middle cerebral artery occlusion

KW - Inflammation

KW - Ischemia

KW - Mesencephalic astrocyte-derived neurotrophic factor

KW - Neuroprotection

KW - 3112 Neurosciences

U2 - 10.1186/s40478-023-01701-y

DO - 10.1186/s40478-023-01701-y

M3 - Article

C2 - 38229173

SN - 2051-5960

VL - 12

JO - Acta Neuropathologica Communications

JF - Acta Neuropathologica Communications

M1 - 10

ER -