Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Selective, precise and high-throughput manipulation of individual superparamagnetic microparticles has profound applications in performing location-tailored in vitro biomedical studies. The current techniques for manipulation of microparticles allow only a single particle in the manipulation workspace, or simultaneous transportation of multiple microparticles in batches. In this work, a method based on a robotized electromagnetic needle for manipulation of individual superparamagnetic microparticles within a microparticle population is introduced. By automatically controlling the highly localized magnetic field of the needle, a single microparticle is selectively picked when its neighboring particle is few micrometers away. Supported by the nanometer resolution of the robotic positioner, particles are placed at sub-micrometer precision. This manipulation technique allows the creating of arbitrary patterns, sorting of microparticles based on size and morphology, and transporting of individual microparticles in three-dimensional space. Therefore, this approach has the potential to enable more deterministic and quantitative microanalysis and microsynthesis using superparamagnetic microparticles.
Original languageEnglish
Article number1700177
JournalAdvanced Materials Technologies
Volume3
Issue number1
Number of pages9
ISSN2365-709X
DOIs
Publication statusPublished - 15 Jan 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 221 Nano-technology
  • 216 Materials engineering
  • 317 Pharmacy
  • electromagnetic needles
  • individual
  • manipulation
  • superparamagnetic microparticles
  • ON-CHIP MANIPULATION
  • MAGNETIC NANOPARTICLES
  • BIOLOGICAL-SYSTEMS
  • PARTICLES
  • FORCE
  • CELLS
  • TWEEZERS
  • BEADS
  • MICROSCOPY
  • PLATFORM

Cite this

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title = "Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle",
abstract = "Selective, precise and high-throughput manipulation of individual superparamagnetic microparticles has profound applications in performing location-tailored in vitro biomedical studies. The current techniques for manipulation of microparticles allow only a single particle in the manipulation workspace, or simultaneous transportation of multiple microparticles in batches. In this work, a method based on a robotized electromagnetic needle for manipulation of individual superparamagnetic microparticles within a microparticle population is introduced. By automatically controlling the highly localized magnetic field of the needle, a single microparticle is selectively picked when its neighboring particle is few micrometers away. Supported by the nanometer resolution of the robotic positioner, particles are placed at sub-micrometer precision. This manipulation technique allows the creating of arbitrary patterns, sorting of microparticles based on size and morphology, and transporting of individual microparticles in three-dimensional space. Therefore, this approach has the potential to enable more deterministic and quantitative microanalysis and microsynthesis using superparamagnetic microparticles.",
keywords = "221 Nano-technology, 216 Materials engineering, 317 Pharmacy, electromagnetic needles , individual , manipulation , superparamagnetic microparticles , ON-CHIP MANIPULATION , MAGNETIC NANOPARTICLES , BIOLOGICAL-SYSTEMS , PARTICLES , FORCE , CELLS , TWEEZERS , BEADS , MICROSCOPY , PLATFORM",
author = "Zoran Cenev and Hongbo Zhang and Veikko Sariola and Rahikkala, {Antti Tuomas Antero} and {Almeida Santos}, Helder and Dongfei Liu and Quan Zhou",
year = "2018",
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doi = "10.1002/admt.201700177",
language = "English",
volume = "3",
journal = "Advanced Materials Technologies",
issn = "2365-709X",
publisher = "Wiley",
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Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle. / Cenev, Zoran; Zhang, Hongbo; Sariola, Veikko ; Rahikkala, Antti Tuomas Antero; Almeida Santos, Helder; Liu, Dongfei; Zhou, Quan .

In: Advanced Materials Technologies, Vol. 3, No. 1, 1700177, 15.01.2018.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Cenev, Zoran

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AU - Sariola, Veikko

AU - Rahikkala, Antti Tuomas Antero

AU - Almeida Santos, Helder

AU - Liu, Dongfei

AU - Zhou, Quan

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AB - Selective, precise and high-throughput manipulation of individual superparamagnetic microparticles has profound applications in performing location-tailored in vitro biomedical studies. The current techniques for manipulation of microparticles allow only a single particle in the manipulation workspace, or simultaneous transportation of multiple microparticles in batches. In this work, a method based on a robotized electromagnetic needle for manipulation of individual superparamagnetic microparticles within a microparticle population is introduced. By automatically controlling the highly localized magnetic field of the needle, a single microparticle is selectively picked when its neighboring particle is few micrometers away. Supported by the nanometer resolution of the robotic positioner, particles are placed at sub-micrometer precision. This manipulation technique allows the creating of arbitrary patterns, sorting of microparticles based on size and morphology, and transporting of individual microparticles in three-dimensional space. Therefore, this approach has the potential to enable more deterministic and quantitative microanalysis and microsynthesis using superparamagnetic microparticles.

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