Abstract
Infants born by vaginal delivery are colonized with maternal fecal microbes. Cesarean section (CS) birth disturbs mother-to-neonate transmission. In this study (NCT03568734), we evaluated whether disturbed intestinal microbiota development could be restored in term CS-born infants by postnatal, orally delivered fecal microbiota transplantation (FMT). We recruited 17 mothers, of whom seven were selected after careful screening. Their infants received a diluted fecal sample from their own mothers, taken 3 weeks prior to delivery. All seven infants had an uneventful clinical course during the 3-month follow-up and showed no adverse effects. The temporal development of the fecal microbiota composition of FMT-treated CS-born infants no longer resembled that of untreated CS-born infants but showed significant similarity to that of vaginally born infants, This proof-of-concept study demonstrates that the intestinal microbiota of CS-born infants can be restored postnatally by maternal FMT. However, this should only be done after careful clinical and microbiological screening.
Original language | English |
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Journal | Cell |
Volume | 183 |
Issue number | 2 |
Pages (from-to) | 324-+ |
Number of pages | 16 |
ISSN | 0092-8674 |
DOIs | |
Publication status | Published - 15 Oct 2020 |
MoE publication type | A1 Journal article-refereed |
Fields of Science
- BODY SITES
- COLONIZATION
- REVEALS
- RISK
- SECTION
- SHAPES
- SHORT-TERM
- TRANSMISSION
- 1182 Biochemistry, cell and molecular biology
Projects
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Microbial ecology in the infant gut
Korpela, K., Dikareva, E. & Hickman, B.
Project: University of Helsinki Three-Year Research Project