Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Stephan Wilmes; Maximillian Hafer; Joni Vuorio; Julie A. Tucker; Hauke Winkelmann; Sara Loechte; Tess A. Stanly; Katiuska D. Pulgar Prieto; Chetan Poojari; Vivek Sharma; Christian P. Richter; Rainer Kurre; Stevan R. Hubbard; K. Christopher Garcia; Ignacio Moraga; Ilpo Vattulainen; Ian S. Hitchcock; Jacob Piehler

doi:10.1126/science.aaw3242

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Stephan Wilmes, Maximillian Hafer, Joni Vuorio, Julie A. Tucker, Hauke Winkelmann, Sara Loechte, Tess A. Stanly, Katiuska D. Pulgar Prieto, Chetan Poojari, Vivek Sharma, Christian P. Richter, Rainer Kurre, Stevan R. Hubbard, K. Christopher Garcia, Ignacio Moraga, Ilpo Vattulainen, Ian S. Hitchcock, Jacob Piehler

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Science
Volume	367
Issue number	6478
Pages (from-to)	643-+
Number of pages	58
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.aaw3242
Publication status	Published - 7 Feb 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

GROWTH-HORMONE RECEPTOR
THROMBOPOIETIN RECEPTOR
ERYTHROPOIETIN RECEPTOR
CONSTITUTIVE ACTIVATION
PSEUDOKINASE-DOMAIN
STRUCTURAL BASIS
DIMERIZATION
DYNAMICS
LIGAND
JAK2
114 Physical sciences
221 Nano-technology

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10.1126/science.aaw3242

Molecular mechanisms of mitochondrial enzymes, and their role in health and diseases
Sharma, V. (Project manager), Djurabekova, A. (Participant), Haapanen, O. (Participant), Malkamäki, A. (Participant), Lasham, J. (Participant), Reidelbach, M. (Participant), Chiarini, V. (Participant) & Nyman, A. I. (Participant)
01/01/2018 → 31/12/2021
Project: University of Helsinki Three-Year Research Project

Cite this

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Loechte, S., Stanly, T. A., Prieto, K. D. P., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S., & Piehler, J. (2020). Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science, 367(6478), 643-+. https://doi.org/10.1126/science.aaw3242

@article{8751ce0bb9df41c794a076416242ffed,

title = "Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations",

keywords = "GROWTH-HORMONE RECEPTOR, THROMBOPOIETIN RECEPTOR, ERYTHROPOIETIN RECEPTOR, CONSTITUTIVE ACTIVATION, PSEUDOKINASE-DOMAIN, STRUCTURAL BASIS, DIMERIZATION, DYNAMICS, LIGAND, JAK2, 114 Physical sciences, 221 Nano-technology",

author = "Stephan Wilmes and Maximillian Hafer and Joni Vuorio and Tucker, {Julie A.} and Hauke Winkelmann and Sara Loechte and Stanly, {Tess A.} and Prieto, {Katiuska D. Pulgar} and Chetan Poojari and Vivek Sharma and Richter, {Christian P.} and Rainer Kurre and Hubbard, {Stevan R.} and Garcia, {K. Christopher} and Ignacio Moraga and Ilpo Vattulainen and Hitchcock, {Ian S.} and Jacob Piehler",

year = "2020",

month = feb,

day = "7",

doi = "10.1126/science.aaw3242",

language = "English",

volume = "367",

pages = "643--+",

journal = "Science",

issn = "0036-8075",

publisher = "American association for the advancement of science",

number = "6478",

}

Wilmes, S, Hafer, M, Vuorio, J, Tucker, JA, Winkelmann, H, Loechte, S, Stanly, TA, Prieto, KDP, Poojari, C , Sharma, V, Richter, CP, Kurre, R, Hubbard, SR, Garcia, KC, Moraga, I, Vattulainen, I, Hitchcock, IS & Piehler, J 2020, 'Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations', Science, vol. 367, no. 6478, pp. 643-+. https://doi.org/10.1126/science.aaw3242

TY - JOUR

T1 - Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

AU - Wilmes, Stephan

AU - Hafer, Maximillian

AU - Vuorio, Joni

AU - Tucker, Julie A.

AU - Winkelmann, Hauke

AU - Loechte, Sara

AU - Stanly, Tess A.

AU - Prieto, Katiuska D. Pulgar

AU - Poojari, Chetan

AU - Sharma, Vivek

AU - Richter, Christian P.

AU - Kurre, Rainer

AU - Hubbard, Stevan R.

AU - Garcia, K. Christopher

AU - Moraga, Ignacio

AU - Vattulainen, Ilpo

AU - Hitchcock, Ian S.

AU - Piehler, Jacob

PY - 2020/2/7

Y1 - 2020/2/7

KW - GROWTH-HORMONE RECEPTOR

KW - THROMBOPOIETIN RECEPTOR

KW - ERYTHROPOIETIN RECEPTOR

KW - CONSTITUTIVE ACTIVATION

KW - PSEUDOKINASE-DOMAIN

KW - STRUCTURAL BASIS

KW - DIMERIZATION

KW - DYNAMICS

KW - LIGAND

KW - JAK2

KW - 114 Physical sciences

KW - 221 Nano-technology

U2 - 10.1126/science.aaw3242

DO - 10.1126/science.aaw3242

M3 - Article

SN - 0036-8075

VL - 367

SP - 643-+

JO - Science

JF - Science

IS - 6478

ER -

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Fields of Science

Access to Document

Projects

Molecular mechanisms of mitochondrial enzymes, and their role in health and diseases

Cite this