Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Stephan Wilmes, Maximillian Hafer, Joni Vuorio, Julie A. Tucker, Hauke Winkelmann, Sara Loechte, Tess A. Stanly, Katiuska D. Pulgar Prieto, Chetan Poojari, Vivek Sharma, Christian P. Richter, Rainer Kurre, Stevan R. Hubbard, K. Christopher Garcia, Ignacio Moraga, Ilpo Vattulainen, Ian S. Hitchcock, Jacob Piehler

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalScience
Volume367
Issue number6478
Pages (from-to)643-+
Number of pages58
ISSN0036-8075
DOIs
Publication statusPublished - 7 Feb 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GROWTH-HORMONE RECEPTOR
  • THROMBOPOIETIN RECEPTOR
  • ERYTHROPOIETIN RECEPTOR
  • CONSTITUTIVE ACTIVATION
  • PSEUDOKINASE-DOMAIN
  • STRUCTURAL BASIS
  • DIMERIZATION
  • DYNAMICS
  • LIGAND
  • JAK2
  • 114 Physical sciences
  • 221 Nano-technology

Cite this

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Loechte, S., ... Piehler, J. (2020). Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science, 367(6478), 643-+. https://doi.org/10.1126/science.aaw3242