Mechanisms for cellular cholesterol transport: defects and human disease

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Abstract

This review summarizes the mechanisms of cellular cholesterol transport and monogenic human diseases caused by defects in intracellular cholesterol processing. In addition, selected mouse models of disturbed cholesterol trafficking are discussed. Current pharmacological strategies to prevent atherosclerosis are largely based on altering cellular cholesterol balance and are introduced in this context. Finally, because of the organizing potential of cholesterol in membranes, disturbances in cellular cholesterol transport have implications for a wide variety of human diseases, of which selected examples are given.
Original languageEnglish
JournalPhysiological Reviews
Volume86
Pages (from-to)1237-1261
Number of pages25
ISSN0031-9333
DOIs
Publication statusPublished - 2006
MoE publication typeA1 Journal article-refereed

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