Mechanistic Insight into How PEGylation Reduces the Efficacy of pH-Sensitive Liposomes from Molecular Dynamics Simulations

Mohammad Mahmoudzadeh, Aniket Magarkar, Artturi Koivuniemi, Tomasz Róg, Alex Bunker

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalMolecular Pharmaceutics
Volume18
Issue number7
Pages (from-to)2612-2621
Number of pages10
ISSN1543-8384
DOIs
Publication statusPublished - 5 Jul 2021
MoE publication typeA1 Journal article-refereed

Fields of Science

  • ATOM FORCE-FIELD
  • DRUG-DELIVERY
  • EFFECTIVE INCLUSION
  • HEXAGONAL PHASE
  • INDUCED DESTABILIZATION
  • LIPID-BILAYERS
  • PARTICLE MESH EWALD
  • PEGylated pH-sensitive liposomes
  • PHASE-TRANSITION
  • POTENTIAL FUNCTIONS
  • TRIGGERED RELEASE
  • bilayer hydrophilicity
  • cholesteryl hemisuccinate
  • molecular dynamics simulations
  • phase transition
  • 317 Pharmacy

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