Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids

Laura Giorgi; Akseli Niemelä; Esa-Pekka Kumpula; Ossi Natri; Petteri Parkkila; Juha T. Huiskonen; Artturi Koivuniemi

doi:10.1021/acs.molpharmaceut.2c00540

Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids

Laura Giorgi, Akseli Niemelä, Esa-Pekka Kumpula, Ossi Natri, Petteri Parkkila, Juha T. Huiskonen, Artturi Koivuniemi

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Molecular Pharmaceutics
Volume	19
Issue number	11
Pages (from-to)	4135-4148
Number of pages	14
ISSN	1543-8384
DOIs	https://doi.org/10.1021/acs.molpharmaceut.2c00540
Publication status	Published - 7 Nov 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

acyltransferase
reverse cholesterol transport
apolipoprotein mimetics
high-density lipoprotein (HDL)
molecular dynamics simulation
electron microscopy imaging
HIGH-DENSITY-LIPOPROTEINS
LECITHINCHOLESTEROL ACYLTRANSFERASE
DISCOIDAL COMPLEXES
TRANSITIONS
DOMAIN
SIZE
317 Pharmacy

Access to Document

10.1021/acs.molpharmaceut.2c00540Licence: CC BY

acs.molpharmaceut.2c00540Final published version, 9.31 MBLicence: CC BY

Cite this

Giorgi, L., Niemelä, A., Kumpula, E.-P., Natri, O., Parkkila, P., Huiskonen, J. T., & Koivuniemi, A. (2022). Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids. Molecular Pharmaceutics, 19(11), 4135-4148. https://doi.org/10.1021/acs.molpharmaceut.2c00540

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title = "Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids",

keywords = "acyltransferase, reverse cholesterol transport, apolipoprotein mimetics, high-density lipoprotein (HDL), molecular dynamics simulation, electron microscopy imaging, HIGH-DENSITY-LIPOPROTEINS, LECITHINCHOLESTEROL ACYLTRANSFERASE, DISCOIDAL COMPLEXES, TRANSITIONS, DOMAIN, SIZE, 317 Pharmacy",

author = "Laura Giorgi and Akseli Niemel{\"a} and Esa-Pekka Kumpula and Ossi Natri and Petteri Parkkila and Huiskonen, {Juha T.} and Artturi Koivuniemi",

year = "2022",

month = nov,

day = "7",

doi = "10.1021/acs.molpharmaceut.2c00540",

language = "English",

volume = "19",

pages = "4135--4148",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

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Giorgi, L , Niemelä, A , Kumpula, E-P, Natri, O, Parkkila, P, Huiskonen, JT & Koivuniemi, A 2022, 'Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids', Molecular Pharmaceutics, vol. 19, no. 11, pp. 4135-4148. https://doi.org/10.1021/acs.molpharmaceut.2c00540

Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids. / Giorgi, Laura ; Niemelä, Akseli ; Kumpula, Esa-Pekka et al.
In: Molecular Pharmaceutics, Vol. 19, No. 11, 07.11.2022, p. 4135-4148.

Research output: Contribution to journal › Article › Scientific › peer-review

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AU - Giorgi, Laura

AU - Niemelä, Akseli

AU - Kumpula, Esa-Pekka

AU - Natri, Ossi

AU - Parkkila, Petteri

AU - Huiskonen, Juha T.

AU - Koivuniemi, Artturi

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KW - acyltransferase

KW - reverse cholesterol transport

KW - apolipoprotein mimetics

KW - high-density lipoprotein (HDL)

KW - molecular dynamics simulation

KW - electron microscopy imaging

KW - HIGH-DENSITY-LIPOPROTEINS

KW - LECITHINCHOLESTEROL ACYLTRANSFERASE

KW - DISCOIDAL COMPLEXES

KW - TRANSITIONS

KW - DOMAIN

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JO - Molecular Pharmaceutics

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