Abstract

Large protein families are a prominent feature of plant genomes and their size variation is a key element for adaptation. However, gene and genome duplications pose difficulties for functional characterization and translational research. Here we infer the evolutionary history of the DOMAIN OF UNKNOWN FUNCTION (DUF) 26-containing proteins. The DUF26 emerged in secreted proteins. Domain duplications and rearrangements led to the appearance of CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASES (CRKs) and PLASMODESMATA-LOCALIZED PROTEINS (PDLPs). The DUF26 is land plant-specific but structural analyses of PDLP ectodomains revealed strong similarity to fungal lectins and thus may constitute a group of plant carbohydrate-binding proteins. CRKs expanded through tandem duplications and preferential retention of duplicates following whole genome duplications, whereas PDLPs evolved according to the dosage balance hypothesis. We propose that new gene families mainly expand through small-scale duplications, while fractionation and genetic drift after whole genome multiplications drive families towards dosage balance.
Original languageEnglish
Article number56
JournalCommunications Biology
Volume2
Number of pages18
ISSN2399-3642
DOIs
Publication statusPublished - 8 Feb 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 1181 Ecology, evolutionary biology

Cite this

@article{930be08bff864acea419aa4d00d0283d,
title = "Mechanistic insights into the evolution of DUF26-containing proteins in land plants",
abstract = "Large protein families are a prominent feature of plant genomes and their size variation is a key element for adaptation. However, gene and genome duplications pose difficulties for functional characterization and translational research. Here we infer the evolutionary history of the DOMAIN OF UNKNOWN FUNCTION (DUF) 26-containing proteins. The DUF26 emerged in secreted proteins. Domain duplications and rearrangements led to the appearance of CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASES (CRKs) and PLASMODESMATA-LOCALIZED PROTEINS (PDLPs). The DUF26 is land plant-specific but structural analyses of PDLP ectodomains revealed strong similarity to fungal lectins and thus may constitute a group of plant carbohydrate-binding proteins. CRKs expanded through tandem duplications and preferential retention of duplicates following whole genome duplications, whereas PDLPs evolved according to the dosage balance hypothesis. We propose that new gene families mainly expand through small-scale duplications, while fractionation and genetic drift after whole genome multiplications drive families towards dosage balance.",
keywords = "1181 Ecology, evolutionary biology",
author = "Aleksia Vaattovaara and Benjamin Brandt and Sitaram Rajaraman and Omid Safronov and Andres Veidenberg and Mark{\'e}ta Luklov{\'a} and Jaakko Kangasj{\"a}rvi and Ari L{\"o}ytynoja and Michael Hothorn and Jarkko Saloj{\"a}rvi and Michael Wrzaczek",
year = "2019",
month = "2",
day = "8",
doi = "10.1038/s42003-019-0306-9",
language = "English",
volume = "2",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Springer Nature",

}

Mechanistic insights into the evolution of DUF26-containing proteins in land plants. / Vaattovaara, Aleksia; Brandt, Benjamin; Rajaraman, Sitaram; Safronov, Omid; Veidenberg, Andres; Luklová, Markéta; Kangasjärvi, Jaakko; Löytynoja, Ari; Hothorn, Michael ; Salojärvi, Jarkko; Wrzaczek, Michael.

In: Communications Biology, Vol. 2, 56, 08.02.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Mechanistic insights into the evolution of DUF26-containing proteins in land plants

AU - Vaattovaara, Aleksia

AU - Brandt, Benjamin

AU - Rajaraman, Sitaram

AU - Safronov, Omid

AU - Veidenberg, Andres

AU - Luklová, Markéta

AU - Kangasjärvi, Jaakko

AU - Löytynoja, Ari

AU - Hothorn, Michael

AU - Salojärvi, Jarkko

AU - Wrzaczek, Michael

PY - 2019/2/8

Y1 - 2019/2/8

N2 - Large protein families are a prominent feature of plant genomes and their size variation is a key element for adaptation. However, gene and genome duplications pose difficulties for functional characterization and translational research. Here we infer the evolutionary history of the DOMAIN OF UNKNOWN FUNCTION (DUF) 26-containing proteins. The DUF26 emerged in secreted proteins. Domain duplications and rearrangements led to the appearance of CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASES (CRKs) and PLASMODESMATA-LOCALIZED PROTEINS (PDLPs). The DUF26 is land plant-specific but structural analyses of PDLP ectodomains revealed strong similarity to fungal lectins and thus may constitute a group of plant carbohydrate-binding proteins. CRKs expanded through tandem duplications and preferential retention of duplicates following whole genome duplications, whereas PDLPs evolved according to the dosage balance hypothesis. We propose that new gene families mainly expand through small-scale duplications, while fractionation and genetic drift after whole genome multiplications drive families towards dosage balance.

AB - Large protein families are a prominent feature of plant genomes and their size variation is a key element for adaptation. However, gene and genome duplications pose difficulties for functional characterization and translational research. Here we infer the evolutionary history of the DOMAIN OF UNKNOWN FUNCTION (DUF) 26-containing proteins. The DUF26 emerged in secreted proteins. Domain duplications and rearrangements led to the appearance of CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASES (CRKs) and PLASMODESMATA-LOCALIZED PROTEINS (PDLPs). The DUF26 is land plant-specific but structural analyses of PDLP ectodomains revealed strong similarity to fungal lectins and thus may constitute a group of plant carbohydrate-binding proteins. CRKs expanded through tandem duplications and preferential retention of duplicates following whole genome duplications, whereas PDLPs evolved according to the dosage balance hypothesis. We propose that new gene families mainly expand through small-scale duplications, while fractionation and genetic drift after whole genome multiplications drive families towards dosage balance.

KW - 1181 Ecology, evolutionary biology

U2 - 10.1038/s42003-019-0306-9

DO - 10.1038/s42003-019-0306-9

M3 - Article

VL - 2

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

M1 - 56

ER -