Melankolisen masennuksen yhteys kuolleisuuteen

Mia D. Eriksson, Johan G. Eriksson, Päivi Korhonen, Hannu Koponen, Minna K. Salonen, Tuija M. Mikkola, Eero Kajantie, Niko S. Wasenius, Mikaela von Bonsdorff, Hannu Kautiainen, Merja K. Laine

Research output: Contribution to journalComment/debateProfessional


Background Individuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon. Methods One thousand nine hundred and ninety five participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated. Results Participants were followed up for a total of 28,044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02-2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85-1.44)] and melancholic depressive [1.26 (95% CI: 0.87-1.81)] groups had higher mortality than the non-depressive group [0.82 (95% CI: 0.73-0.93)]. Conclusions Melancholic depressive symptoms are most strongly related to a higher mortality risk.
Original languageFinnish
Issue number23
Pages (from-to)2085-2085
Number of pages1
Publication statusPublished - Feb 2023
MoE publication typeD1 Article in a trade journal

Fields of Science

  • 3124 Neurology and psychiatry

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