Membrane translocation at the ER: with a little help from my friends

Sarah O'Keefe; Stephen High

doi:10.1111/febs.15309

Membrane translocation at the ER: with a little help from my friends

Research output: Contribution to journal › Comment/debate › Scientific › peer-review

Abstract

The Sec61 complex is the proteinaceous pore through which one-third of mammalian polypeptides access the lumen of the endoplasmic reticulum (ER) during their translocation across, or insertion into, the ER membrane. N-terminal ER signal peptides mediate polypeptide targeting to, and opening of, the Sec61 channel in a substrate-specific manner. Here, we discuss the recently defined features of ER signal peptides which necessitate the use of the accessory components Sec62 and Sec63 during the Sec61-mediated cotranslational translocation of newly synthesized secretory proteins.

Original language	English
Journal	FEBS Journal
Volume	287
Issue number	21
Pages (from-to)	4607-4611
Number of pages	5
ISSN	1742-464X
DOIs	https://doi.org/10.1111/febs.15309
Publication status	Published - 1 Nov 2020
Externally published	Yes
MoE publication type	A1 Journal article-refereed

Bibliographical note

Funding Information:
The authors thank Lisa Swanton for advice. This work was supported by a Wellcome Trust Investigator Award in Science (204957/Z/16/Z).

Publisher Copyright:
© 2020 Federation of European Biochemical Societies

Fields of Science

endoplasmic reticulum
Sec61 complex
Sec62/Sec63
signal peptides
translocon gating

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10.1111/febs.15309

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title = "Membrane translocation at the ER: with a little help from my friends",

abstract = "The Sec61 complex is the proteinaceous pore through which one-third of mammalian polypeptides access the lumen of the endoplasmic reticulum (ER) during their translocation across, or insertion into, the ER membrane. N-terminal ER signal peptides mediate polypeptide targeting to, and opening of, the Sec61 channel in a substrate-specific manner. Here, we discuss the recently defined features of ER signal peptides which necessitate the use of the accessory components Sec62 and Sec63 during the Sec61-mediated cotranslational translocation of newly synthesized secretory proteins.",

keywords = "endoplasmic reticulum, Sec61 complex, Sec62/Sec63, signal peptides, translocon gating",

author = "Sarah O'Keefe and Stephen High",

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AU - O'Keefe, Sarah

AU - High, Stephen

N1 - Funding Information: The authors thank Lisa Swanton for advice. This work was supported by a Wellcome Trust Investigator Award in Science (204957/Z/16/Z). Publisher Copyright: © 2020 Federation of European Biochemical Societies

PY - 2020/11/1

Y1 - 2020/11/1

N2 - The Sec61 complex is the proteinaceous pore through which one-third of mammalian polypeptides access the lumen of the endoplasmic reticulum (ER) during their translocation across, or insertion into, the ER membrane. N-terminal ER signal peptides mediate polypeptide targeting to, and opening of, the Sec61 channel in a substrate-specific manner. Here, we discuss the recently defined features of ER signal peptides which necessitate the use of the accessory components Sec62 and Sec63 during the Sec61-mediated cotranslational translocation of newly synthesized secretory proteins.

AB - The Sec61 complex is the proteinaceous pore through which one-third of mammalian polypeptides access the lumen of the endoplasmic reticulum (ER) during their translocation across, or insertion into, the ER membrane. N-terminal ER signal peptides mediate polypeptide targeting to, and opening of, the Sec61 channel in a substrate-specific manner. Here, we discuss the recently defined features of ER signal peptides which necessitate the use of the accessory components Sec62 and Sec63 during the Sec61-mediated cotranslational translocation of newly synthesized secretory proteins.

KW - endoplasmic reticulum

KW - Sec61 complex

KW - Sec62/Sec63

KW - signal peptides

KW - translocon gating

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DO - 10.1111/febs.15309

M3 - Comment/debate

SN - 1742-464X

VL - 287

SP - 4607

EP - 4611

JO - FEBS Journal

JF - FEBS Journal

IS - 21

ER -

Membrane translocation at the ER: with a little help from my friends

Abstract

Bibliographical note

Fields of Science

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