Membrane transporters in drug development

Kathleen M. Giacomini, Shiew-Mei Huang, Donald J. Tweedie, Leslie Z. Benet, Kim L. R. Brouwer, Xiaoyan Chu, Amber Dahlin, Raymond Evers, Volker Fischer, Kathleen M. Hillgren, Keith A. Hoffmaster, Toshihisa Ishikawa, Dietrich Keppler, Richard B. Kim, Caroline A. Lee, Mikko Niemi, Joseph W. Polli, Yuicchi Sugiyama, Peter W. Swaan, Joseph A. Ware & 5 others Stephen H. Wright, Sook Wah Yee, Maciej J. Zamek-Gliszczynski, Lei Zhang, International Transporter

Research output: Contribution to journalReview ArticleScientificpeer-review

Original languageEnglish
JournalNature reviews. Drug discovery
Volume9
Pages (from-to)215-236
Number of pages22
DOIs
Publication statusPublished - 2010
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • CANCER RESISTANCE PROTEIN
  • BLOOD-BRAIN-BARRIER
  • ORGANIC CATION TRANSPORTER-2
  • VITRO-IN-VIVO
  • CENTRAL-NERVOUS-SYSTEM
  • NONSTEROIDAL ANTIINFLAMMATORY DRUGS
  • SINGLE NUCLEOTIDE POLYMORPHISMS
  • PHARMACOPHORE-BASED DISCOVERY
  • POSITRON-EMISSION-TOMOGRAPHY
  • DUBIN-JOHNSON-SYNDROME
  • 312 Clinical medicine

Cite this

Giacomini, K. M., Huang, S-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., ... International Transporter (2010). Membrane transporters in drug development. Nature reviews. Drug discovery, 9, 215-236. https://doi.org/10.1038/nrd3028
Giacomini, Kathleen M. ; Huang, Shiew-Mei ; Tweedie, Donald J. ; Benet, Leslie Z. ; Brouwer, Kim L. R. ; Chu, Xiaoyan ; Dahlin, Amber ; Evers, Raymond ; Fischer, Volker ; Hillgren, Kathleen M. ; Hoffmaster, Keith A. ; Ishikawa, Toshihisa ; Keppler, Dietrich ; Kim, Richard B. ; Lee, Caroline A. ; Niemi, Mikko ; Polli, Joseph W. ; Sugiyama, Yuicchi ; Swaan, Peter W. ; Ware, Joseph A. ; Wright, Stephen H. ; Yee, Sook Wah ; Zamek-Gliszczynski, Maciej J. ; Zhang, Lei ; International Transporter. / Membrane transporters in drug development. In: Nature reviews. Drug discovery. 2010 ; Vol. 9. pp. 215-236.
@article{866b3f48675244859350253aead012c1,
title = "Membrane transporters in drug development",
keywords = "CANCER RESISTANCE PROTEIN, BLOOD-BRAIN-BARRIER, ORGANIC CATION TRANSPORTER-2, VITRO-IN-VIVO, CENTRAL-NERVOUS-SYSTEM, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, SINGLE NUCLEOTIDE POLYMORPHISMS, PHARMACOPHORE-BASED DISCOVERY, POSITRON-EMISSION-TOMOGRAPHY, DUBIN-JOHNSON-SYNDROME, 312 Clinical medicine",
author = "Giacomini, {Kathleen M.} and Shiew-Mei Huang and Tweedie, {Donald J.} and Benet, {Leslie Z.} and Brouwer, {Kim L. R.} and Xiaoyan Chu and Amber Dahlin and Raymond Evers and Volker Fischer and Hillgren, {Kathleen M.} and Hoffmaster, {Keith A.} and Toshihisa Ishikawa and Dietrich Keppler and Kim, {Richard B.} and Lee, {Caroline A.} and Mikko Niemi and Polli, {Joseph W.} and Yuicchi Sugiyama and Swaan, {Peter W.} and Ware, {Joseph A.} and Wright, {Stephen H.} and Yee, {Sook Wah} and Zamek-Gliszczynski, {Maciej J.} and Lei Zhang and {International Transporter}",
year = "2010",
doi = "10.1038/nrd3028",
language = "English",
volume = "9",
pages = "215--236",
journal = "Nature reviews. Drug discovery",
issn = "1474-1776",
publisher = "Nature Publishing Group",

}

Giacomini, KM, Huang, S-M, Tweedie, DJ, Benet, LZ, Brouwer, KLR, Chu, X, Dahlin, A, Evers, R, Fischer, V, Hillgren, KM, Hoffmaster, KA, Ishikawa, T, Keppler, D, Kim, RB, Lee, CA, Niemi, M, Polli, JW, Sugiyama, Y, Swaan, PW, Ware, JA, Wright, SH, Yee, SW, Zamek-Gliszczynski, MJ, Zhang, L & International Transporter 2010, 'Membrane transporters in drug development', Nature reviews. Drug discovery, vol. 9, pp. 215-236. https://doi.org/10.1038/nrd3028

Membrane transporters in drug development. / Giacomini, Kathleen M.; Huang, Shiew-Mei; Tweedie, Donald J.; Benet, Leslie Z.; Brouwer, Kim L. R.; Chu, Xiaoyan; Dahlin, Amber; Evers, Raymond; Fischer, Volker; Hillgren, Kathleen M.; Hoffmaster, Keith A.; Ishikawa, Toshihisa; Keppler, Dietrich; Kim, Richard B.; Lee, Caroline A.; Niemi, Mikko; Polli, Joseph W.; Sugiyama, Yuicchi; Swaan, Peter W.; Ware, Joseph A.; Wright, Stephen H.; Yee, Sook Wah; Zamek-Gliszczynski, Maciej J.; Zhang, Lei; International Transporter.

In: Nature reviews. Drug discovery, Vol. 9, 2010, p. 215-236.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Membrane transporters in drug development

AU - Giacomini, Kathleen M.

AU - Huang, Shiew-Mei

AU - Tweedie, Donald J.

AU - Benet, Leslie Z.

AU - Brouwer, Kim L. R.

AU - Chu, Xiaoyan

AU - Dahlin, Amber

AU - Evers, Raymond

AU - Fischer, Volker

AU - Hillgren, Kathleen M.

AU - Hoffmaster, Keith A.

AU - Ishikawa, Toshihisa

AU - Keppler, Dietrich

AU - Kim, Richard B.

AU - Lee, Caroline A.

AU - Niemi, Mikko

AU - Polli, Joseph W.

AU - Sugiyama, Yuicchi

AU - Swaan, Peter W.

AU - Ware, Joseph A.

AU - Wright, Stephen H.

AU - Yee, Sook Wah

AU - Zamek-Gliszczynski, Maciej J.

AU - Zhang, Lei

AU - International Transporter

PY - 2010

Y1 - 2010

KW - CANCER RESISTANCE PROTEIN

KW - BLOOD-BRAIN-BARRIER

KW - ORGANIC CATION TRANSPORTER-2

KW - VITRO-IN-VIVO

KW - CENTRAL-NERVOUS-SYSTEM

KW - NONSTEROIDAL ANTIINFLAMMATORY DRUGS

KW - SINGLE NUCLEOTIDE POLYMORPHISMS

KW - PHARMACOPHORE-BASED DISCOVERY

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - DUBIN-JOHNSON-SYNDROME

KW - 312 Clinical medicine

U2 - 10.1038/nrd3028

DO - 10.1038/nrd3028

M3 - Review Article

VL - 9

SP - 215

EP - 236

JO - Nature reviews. Drug discovery

JF - Nature reviews. Drug discovery

SN - 1474-1776

ER -

Giacomini KM, Huang S-M, Tweedie DJ, Benet LZ, Brouwer KLR, Chu X et al. Membrane transporters in drug development. Nature reviews. Drug discovery. 2010;9:215-236. https://doi.org/10.1038/nrd3028