Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Henry Rodriguez-Broadbent; Philip J. Law; Amit Sud; Kimmo Palin; Sari Tuupanen; Alexandra Gylfe; Ulrika A. Hanninen; Tatiana Cajuso; Tomas Tanskanen; Johanna Kondelin; Eevi Kaasinen; Antti-Pekka Sarin; Samuli Ripatti; Johan G. Eriksson; Harri Rissanen; Paul Knekt; Eero Pukkala; Pekka Jousilahti; Veikko Salomaa; Aarno Palotie; Laura Renkonen-Sinisalo; Anna Lepisto; Jan Bohm; Jukka-Pekka Mecklin; Nada A. Al-Tassan; Claire Palles; Lynn Martin; Ella Barclay; Susan M. Farrington; Maria N. Timofeeva; Brian F. Meyer; Salma M. Wakil; Harry Campbell; Christopher G. Smith; Shelley Idziaszczyk; Timothy S. Maughan; Richard Kaplan; Rachel Kerr; David Kerr; Michael N. Passarelli; Jane C. Figueiredo; Daniel D. Buchanan; Aung K. Win; John L. Hopper; Mark A. Jenkins; Noralane M. Lindor; Polly A. Newcomb; Steven Gallinger; David Conti; Fred Schumacher; Graham Casey; Lauri A. Aaltonen; Jeremy P. Cheadle; Ian P. Tomlinson; Malcolm G. Dunlop; Richard S. Houlston

doi:10.1002/ijc.30709

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Henry Rodriguez-Broadbent, Philip J. Law, Amit Sud, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A. Hanninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Samuli Ripatti, Johan G. Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Aarno PalotieLaura Renkonen-Sinisalo, Anna Lepisto, Jan Bohm, Jukka-Pekka Mecklin, Nada A. Al-Tassan, Claire Palles, Lynn Martin, Ella Barclay, Susan M. Farrington, Maria N. Timofeeva, Brian F. Meyer, Salma M. Wakil, Harry Campbell, Christopher G. Smith, Shelley Idziaszczyk, Timothy S. Maughan, Richard Kaplan, Rachel Kerr, David Kerr, Michael N. Passarelli, Jane C. Figueiredo, Daniel D. Buchanan, Aung K. Win, John L. Hopper, Mark A. Jenkins, Noralane M. Lindor, Polly A. Newcomb, Steven Gallinger, David Conti, Fred Schumacher, Graham Casey, Lauri A. Aaltonen, Jeremy P. Cheadle, Ian P. Tomlinson, Malcolm G. Dunlop, Richard S. Houlston

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	International Journal of Cancer
Volume	140
Issue number	12
Pages (from-to)	2701-2708
Number of pages	8
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.30709
Publication status	Published - 15 Jun 2017
MoE publication type	A1 Journal article-refereed

Fields of Science

Mendelian randomisation
hyperlipidaemia
cholesterol
colorectal cancer
risk
GENOME-WIDE METAANALYSIS
BLOOD-LIPIDS
DISEASE
IDENTIFICATION
REGRESSION
TRAITS
LOCI
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology

Access to Document

10.1002/ijc.30709

Cite this

Rodriguez-Broadbent, H., Law, P. J., Sud, A., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Ripatti, S., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., ... Houlston, R. S. (2017). Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. International Journal of Cancer, 140(12), 2701-2708. https://doi.org/10.1002/ijc.30709

Rodriguez-Broadbent, Henry ; Law, Philip J. ; Sud, Amit ; Palin, Kimmo ; Tuupanen, Sari ; Gylfe, Alexandra ; Hanninen, Ulrika A. ; Cajuso, Tatiana ; Tanskanen, Tomas ; Kondelin, Johanna ; Kaasinen, Eevi ; Sarin, Antti-Pekka ; Ripatti, Samuli ; Eriksson, Johan G. ; Rissanen, Harri ; Knekt, Paul ; Pukkala, Eero ; Jousilahti, Pekka ; Salomaa, Veikko ; Palotie, Aarno ; Renkonen-Sinisalo, Laura ; Lepisto, Anna ; Bohm, Jan ; Mecklin, Jukka-Pekka ; Al-Tassan, Nada A. ; Palles, Claire ; Martin, Lynn ; Barclay, Ella ; Farrington, Susan M. ; Timofeeva, Maria N. ; Meyer, Brian F. ; Wakil, Salma M. ; Campbell, Harry ; Smith, Christopher G. ; Idziaszczyk, Shelley ; Maughan, Timothy S. ; Kaplan, Richard ; Kerr, Rachel ; Kerr, David ; Passarelli, Michael N. ; Figueiredo, Jane C. ; Buchanan, Daniel D. ; Win, Aung K. ; Hopper, John L. ; Jenkins, Mark A. ; Lindor, Noralane M. ; Newcomb, Polly A. ; Gallinger, Steven ; Conti, David ; Schumacher, Fred ; Casey, Graham ; Aaltonen, Lauri A. ; Cheadle, Jeremy P. ; Tomlinson, Ian P. ; Dunlop, Malcolm G. ; Houlston, Richard S. / Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. In: International Journal of Cancer. 2017 ; Vol. 140, No. 12. pp. 2701-2708.

@article{881214e7d10b4e6bacf021d4bf88f10e,

title = "Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer",

keywords = "Mendelian randomisation, hyperlipidaemia, cholesterol, colorectal cancer, risk, GENOME-WIDE METAANALYSIS, BLOOD-LIPIDS, DISEASE, IDENTIFICATION, REGRESSION, TRAITS, LOCI, 3122 Cancers, 3126 Surgery, anesthesiology, intensive care, radiology",

author = "Henry Rodriguez-Broadbent and Law, {Philip J.} and Amit Sud and Kimmo Palin and Sari Tuupanen and Alexandra Gylfe and Hanninen, {Ulrika A.} and Tatiana Cajuso and Tomas Tanskanen and Johanna Kondelin and Eevi Kaasinen and Antti-Pekka Sarin and Samuli Ripatti and Eriksson, {Johan G.} and Harri Rissanen and Paul Knekt and Eero Pukkala and Pekka Jousilahti and Veikko Salomaa and Aarno Palotie and Laura Renkonen-Sinisalo and Anna Lepisto and Jan Bohm and Jukka-Pekka Mecklin and Al-Tassan, {Nada A.} and Claire Palles and Lynn Martin and Ella Barclay and Farrington, {Susan M.} and Timofeeva, {Maria N.} and Meyer, {Brian F.} and Wakil, {Salma M.} and Harry Campbell and Smith, {Christopher G.} and Shelley Idziaszczyk and Maughan, {Timothy S.} and Richard Kaplan and Rachel Kerr and David Kerr and Passarelli, {Michael N.} and Figueiredo, {Jane C.} and Buchanan, {Daniel D.} and Win, {Aung K.} and Hopper, {John L.} and Jenkins, {Mark A.} and Lindor, {Noralane M.} and Newcomb, {Polly A.} and Steven Gallinger and David Conti and Fred Schumacher and Graham Casey and Aaltonen, {Lauri A.} and Cheadle, {Jeremy P.} and Tomlinson, {Ian P.} and Dunlop, {Malcolm G.} and Houlston, {Richard S.}",

year = "2017",

month = jun,

day = "15",

doi = "10.1002/ijc.30709",

language = "English",

volume = "140",

pages = "2701--2708",

journal = "International Journal of Cancer",

issn = "0020-7136",

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Rodriguez-Broadbent, H, Law, PJ, Sud, A, Palin, K, Tuupanen, S, Gylfe, A, Hanninen, UA, Cajuso, T, Tanskanen, T, Kondelin, J , Kaasinen, E, Sarin, A-P, Ripatti, S , Eriksson, JG, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Palotie, A, Renkonen-Sinisalo, L, Lepisto, A, Bohm, J, Mecklin, J-P, Al-Tassan, NA, Palles, C, Martin, L, Barclay, E, Farrington, SM, Timofeeva, MN, Meyer, BF, Wakil, SM, Campbell, H, Smith, CG, Idziaszczyk, S, Maughan, TS, Kaplan, R, Kerr, R, Kerr, D, Passarelli, MN, Figueiredo, JC, Buchanan, DD, Win, AK, Hopper, JL, Jenkins, MA, Lindor, NM, Newcomb, PA, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Aaltonen, LA, Cheadle, JP, Tomlinson, IP, Dunlop, MG & Houlston, RS 2017, 'Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer', International Journal of Cancer, vol. 140, no. 12, pp. 2701-2708. https://doi.org/10.1002/ijc.30709

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. / Rodriguez-Broadbent, Henry; Law, Philip J.; Sud, Amit; Palin, Kimmo; Tuupanen, Sari; Gylfe, Alexandra; Hanninen, Ulrika A.; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna ; Kaasinen, Eevi; Sarin, Antti-Pekka; Ripatti, Samuli ; Eriksson, Johan G.; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Palotie, Aarno; Renkonen-Sinisalo, Laura; Lepisto, Anna; Bohm, Jan; Mecklin, Jukka-Pekka; Al-Tassan, Nada A.; Palles, Claire; Martin, Lynn; Barclay, Ella; Farrington, Susan M.; Timofeeva, Maria N.; Meyer, Brian F.; Wakil, Salma M.; Campbell, Harry; Smith, Christopher G.; Idziaszczyk, Shelley; Maughan, Timothy S.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Passarelli, Michael N.; Figueiredo, Jane C.; Buchanan, Daniel D.; Win, Aung K.; Hopper, John L.; Jenkins, Mark A.; Lindor, Noralane M.; Newcomb, Polly A.; Gallinger, Steven; Conti, David; Schumacher, Fred; Casey, Graham; Aaltonen, Lauri A.; Cheadle, Jeremy P.; Tomlinson, Ian P.; Dunlop, Malcolm G.; Houlston, Richard S.

In: International Journal of Cancer, Vol. 140, No. 12, 15.06.2017, p. 2701-2708.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

AU - Rodriguez-Broadbent, Henry

AU - Law, Philip J.

AU - Sud, Amit

AU - Palin, Kimmo

AU - Tuupanen, Sari

AU - Gylfe, Alexandra

AU - Hanninen, Ulrika A.

AU - Cajuso, Tatiana

AU - Tanskanen, Tomas

AU - Kondelin, Johanna

AU - Kaasinen, Eevi

AU - Sarin, Antti-Pekka

AU - Ripatti, Samuli

AU - Eriksson, Johan G.

AU - Rissanen, Harri

AU - Knekt, Paul

AU - Pukkala, Eero

AU - Jousilahti, Pekka

AU - Salomaa, Veikko

AU - Palotie, Aarno

AU - Renkonen-Sinisalo, Laura

AU - Lepisto, Anna

AU - Bohm, Jan

AU - Mecklin, Jukka-Pekka

AU - Al-Tassan, Nada A.

AU - Palles, Claire

AU - Martin, Lynn

AU - Barclay, Ella

AU - Farrington, Susan M.

AU - Timofeeva, Maria N.

AU - Meyer, Brian F.

AU - Wakil, Salma M.

AU - Campbell, Harry

AU - Smith, Christopher G.

AU - Idziaszczyk, Shelley

AU - Maughan, Timothy S.

AU - Kaplan, Richard

AU - Kerr, Rachel

AU - Kerr, David

AU - Passarelli, Michael N.

AU - Figueiredo, Jane C.

AU - Buchanan, Daniel D.

AU - Win, Aung K.

AU - Hopper, John L.

AU - Jenkins, Mark A.

AU - Lindor, Noralane M.

AU - Newcomb, Polly A.

AU - Gallinger, Steven

AU - Conti, David

AU - Schumacher, Fred

AU - Casey, Graham

AU - Aaltonen, Lauri A.

AU - Cheadle, Jeremy P.

AU - Tomlinson, Ian P.

AU - Dunlop, Malcolm G.

AU - Houlston, Richard S.

PY - 2017/6/15

Y1 - 2017/6/15

KW - Mendelian randomisation

KW - hyperlipidaemia

KW - cholesterol

KW - colorectal cancer

KW - risk

KW - GENOME-WIDE METAANALYSIS

KW - BLOOD-LIPIDS

KW - DISEASE

KW - IDENTIFICATION

KW - REGRESSION

KW - TRAITS

KW - LOCI

KW - 3122 Cancers

KW - 3126 Surgery, anesthesiology, intensive care, radiology

U2 - 10.1002/ijc.30709

DO - 10.1002/ijc.30709

M3 - Article

VL - 140

SP - 2701

EP - 2708

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 12

ER -