Mesoporous Silica Nanoparticles for Targeted and Stimuli-responsive Delivery of Chemotherapeutics: A Review

Antti Tuomas Antero Rahikkala, Sarah Pereira, Patricia Isabel Figueiredo, Marieta Passos, André Araújo, M. Lúcia Saraiva, Helder Almeida Santos

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Mesoporous silica nanoparticles (MSNs) exhibit the typical characteristics of inorganic materials that make them a promising drug delivery carrier for cancer therapy. Their structural properties allow the targeted delivery of chemotherapeutic drugs to enhance drug efficacy and reduce adverse effects. The functionalization of MSNs with targeting ligands to a specific tissue/cell and stimuli-responsive capping materials to seal drugs inside the MSNs pores have been widely studied for biomedical and pharmaceutical applications. Furthermore, multiple stimuli-responsive MSN-based drug delivery systems have been developed to enhance the delivery of anticancer drugs to their specific target and thereby improve the release of the drugs at the intended site. In addition, several toxicity studies have been conducted to evaluate the biosafety and biocompatibility of MSNs. Although MSNs present reduced toxicity compared to colloidal silica, they can induce cytotoxicity associated with oxidative stress by increased reactive oxygen species production and decreased glutathione levels that can ultimately lead to cell death. However, different modifications to control morphology and surface composition can be done to overcome the biocompatibility concerns. In this review, we provide a comprehensive overview of the controlled synthesis, functionalization, targeting and biocompatibility of MSNs, as well as their biomedical application as a chemotherapeutic delivery system.
Original languageEnglish
Article number1800020
JournalAdvanced Biosystems
Volume2
Issue number7
Number of pages33
ISSN2366-7478
DOIs
Publication statusPublished - Jul 2018
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy

Cite this

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title = "Mesoporous Silica Nanoparticles for Targeted and Stimuli-responsive Delivery of Chemotherapeutics: A Review",
abstract = "Mesoporous silica nanoparticles (MSNs) exhibit the typical characteristics of inorganic materials that make them a promising drug delivery carrier for cancer therapy. Their structural properties allow the targeted delivery of chemotherapeutic drugs to enhance drug efficacy and reduce adverse effects. The functionalization of MSNs with targeting ligands to a specific tissue/cell and stimuli-responsive capping materials to seal drugs inside the MSNs pores have been widely studied for biomedical and pharmaceutical applications. Furthermore, multiple stimuli-responsive MSN-based drug delivery systems have been developed to enhance the delivery of anticancer drugs to their specific target and thereby improve the release of the drugs at the intended site. In addition, several toxicity studies have been conducted to evaluate the biosafety and biocompatibility of MSNs. Although MSNs present reduced toxicity compared to colloidal silica, they can induce cytotoxicity associated with oxidative stress by increased reactive oxygen species production and decreased glutathione levels that can ultimately lead to cell death. However, different modifications to control morphology and surface composition can be done to overcome the biocompatibility concerns. In this review, we provide a comprehensive overview of the controlled synthesis, functionalization, targeting and biocompatibility of MSNs, as well as their biomedical application as a chemotherapeutic delivery system.",
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Mesoporous Silica Nanoparticles for Targeted and Stimuli-responsive Delivery of Chemotherapeutics: A Review. / Rahikkala, Antti Tuomas Antero; Pereira, Sarah; Figueiredo, Patricia Isabel; Passos, Marieta ; Araújo, André; Saraiva, M. Lúcia; Almeida Santos, Helder.

In: Advanced Biosystems, Vol. 2, No. 7, 1800020, 07.2018.

Research output: Contribution to journalReview ArticleScientificpeer-review

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T1 - Mesoporous Silica Nanoparticles for Targeted and Stimuli-responsive Delivery of Chemotherapeutics: A Review

AU - Rahikkala, Antti Tuomas Antero

AU - Pereira, Sarah

AU - Figueiredo, Patricia Isabel

AU - Passos, Marieta

AU - Araújo, André

AU - Saraiva, M. Lúcia

AU - Almeida Santos, Helder

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N2 - Mesoporous silica nanoparticles (MSNs) exhibit the typical characteristics of inorganic materials that make them a promising drug delivery carrier for cancer therapy. Their structural properties allow the targeted delivery of chemotherapeutic drugs to enhance drug efficacy and reduce adverse effects. The functionalization of MSNs with targeting ligands to a specific tissue/cell and stimuli-responsive capping materials to seal drugs inside the MSNs pores have been widely studied for biomedical and pharmaceutical applications. Furthermore, multiple stimuli-responsive MSN-based drug delivery systems have been developed to enhance the delivery of anticancer drugs to their specific target and thereby improve the release of the drugs at the intended site. In addition, several toxicity studies have been conducted to evaluate the biosafety and biocompatibility of MSNs. Although MSNs present reduced toxicity compared to colloidal silica, they can induce cytotoxicity associated with oxidative stress by increased reactive oxygen species production and decreased glutathione levels that can ultimately lead to cell death. However, different modifications to control morphology and surface composition can be done to overcome the biocompatibility concerns. In this review, we provide a comprehensive overview of the controlled synthesis, functionalization, targeting and biocompatibility of MSNs, as well as their biomedical application as a chemotherapeutic delivery system.

AB - Mesoporous silica nanoparticles (MSNs) exhibit the typical characteristics of inorganic materials that make them a promising drug delivery carrier for cancer therapy. Their structural properties allow the targeted delivery of chemotherapeutic drugs to enhance drug efficacy and reduce adverse effects. The functionalization of MSNs with targeting ligands to a specific tissue/cell and stimuli-responsive capping materials to seal drugs inside the MSNs pores have been widely studied for biomedical and pharmaceutical applications. Furthermore, multiple stimuli-responsive MSN-based drug delivery systems have been developed to enhance the delivery of anticancer drugs to their specific target and thereby improve the release of the drugs at the intended site. In addition, several toxicity studies have been conducted to evaluate the biosafety and biocompatibility of MSNs. Although MSNs present reduced toxicity compared to colloidal silica, they can induce cytotoxicity associated with oxidative stress by increased reactive oxygen species production and decreased glutathione levels that can ultimately lead to cell death. However, different modifications to control morphology and surface composition can be done to overcome the biocompatibility concerns. In this review, we provide a comprehensive overview of the controlled synthesis, functionalization, targeting and biocompatibility of MSNs, as well as their biomedical application as a chemotherapeutic delivery system.

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