Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Elisabeth M. van Leeuwen, Aniko Sabo, Joshua C. Bis, Jennifer E. Huffman, Ani Manichaikul, Albert V. Smith, Mary F. Feitosa, Serkalem Demissie, Peter K. Joshi, Qing Duan, Jonathan Marten, Jan B. van Klinken, Ida Surakka, Ilja M. Nolte, Weihua Zhang, Hamdi Mbarek, Ruifang Li-Gao, Stella Trompet, Niek Verweij, Evangelos EvangelouLeo-Pekka Lyytikainen, Bamidele O. Tayo, Joris Deelen, Peter J. van der Most, Sander W. van der Laan, Dan E. Arking, Alanna Morrison, Abbas Dehghan, Oscar H. Franco, Albert Hofman, Fernando Rivadeneira, Eric J. Sijbrands, Andre G. Uitterlinden, Josyf C. Mychaleckyj, Archie Campbell, Lynne J. Hocking, Sandosh Padmanabhan, Jennifer A. Brody, Kenneth M. Rice, Charles C. White, Tamara Harris, Aaron Isaacs, Harry Campbell, Leslie A. Lange, Igor Rudan, Ivana Kolcic, Pau Navarro, Tatijana Zemunik, Veikko Salomaa, Samuli Ripatti, CHARGE Lipids Working Grp

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Medical Genetics
Volume53
Issue number7
Pages (from-to)441-449
Number of pages9
ISSN0022-2593
DOIs
Publication statusPublished - Jul 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • ELEMENT-BINDING PROTEIN
  • GENE-EXPRESSION
  • LIPID-SYNTHESIS
  • GLUCOSE
  • CHREBP
  • MUTATIONS
  • TRIGLYCERIDES
  • TRANSCRIPTION
  • SREBP-1C
  • DISEASE
  • 1184 Genetics, developmental biology, physiology
  • 3142 Public health care science, environmental and occupational health

Cite this

van Leeuwen, Elisabeth M. ; Sabo, Aniko ; Bis, Joshua C. ; Huffman, Jennifer E. ; Manichaikul, Ani ; Smith, Albert V. ; Feitosa, Mary F. ; Demissie, Serkalem ; Joshi, Peter K. ; Duan, Qing ; Marten, Jonathan ; van Klinken, Jan B. ; Surakka, Ida ; Nolte, Ilja M. ; Zhang, Weihua ; Mbarek, Hamdi ; Li-Gao, Ruifang ; Trompet, Stella ; Verweij, Niek ; Evangelou, Evangelos ; Lyytikainen, Leo-Pekka ; Tayo, Bamidele O. ; Deelen, Joris ; van der Most, Peter J. ; van der Laan, Sander W. ; Arking, Dan E. ; Morrison, Alanna ; Dehghan, Abbas ; Franco, Oscar H. ; Hofman, Albert ; Rivadeneira, Fernando ; Sijbrands, Eric J. ; Uitterlinden, Andre G. ; Mychaleckyj, Josyf C. ; Campbell, Archie ; Hocking, Lynne J. ; Padmanabhan, Sandosh ; Brody, Jennifer A. ; Rice, Kenneth M. ; White, Charles C. ; Harris, Tamara ; Isaacs, Aaron ; Campbell, Harry ; Lange, Leslie A. ; Rudan, Igor ; Kolcic, Ivana ; Navarro, Pau ; Zemunik, Tatijana ; Salomaa, Veikko ; Ripatti, Samuli ; CHARGE Lipids Working Grp. / Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. In: Journal of Medical Genetics. 2016 ; Vol. 53, No. 7. pp. 441-449.
@article{6f1d9bf346c9473bbcbadc4dd64f0977,
title = "Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels",
keywords = "ELEMENT-BINDING PROTEIN, GENE-EXPRESSION, LIPID-SYNTHESIS, GLUCOSE, CHREBP, MUTATIONS, TRIGLYCERIDES, TRANSCRIPTION, SREBP-1C, DISEASE, 1184 Genetics, developmental biology, physiology, 3142 Public health care science, environmental and occupational health",
author = "{van Leeuwen}, {Elisabeth M.} and Aniko Sabo and Bis, {Joshua C.} and Huffman, {Jennifer E.} and Ani Manichaikul and Smith, {Albert V.} and Feitosa, {Mary F.} and Serkalem Demissie and Joshi, {Peter K.} and Qing Duan and Jonathan Marten and {van Klinken}, {Jan B.} and Ida Surakka and Nolte, {Ilja M.} and Weihua Zhang and Hamdi Mbarek and Ruifang Li-Gao and Stella Trompet and Niek Verweij and Evangelos Evangelou and Leo-Pekka Lyytikainen and Tayo, {Bamidele O.} and Joris Deelen and {van der Most}, {Peter J.} and {van der Laan}, {Sander W.} and Arking, {Dan E.} and Alanna Morrison and Abbas Dehghan and Franco, {Oscar H.} and Albert Hofman and Fernando Rivadeneira and Sijbrands, {Eric J.} and Uitterlinden, {Andre G.} and Mychaleckyj, {Josyf C.} and Archie Campbell and Hocking, {Lynne J.} and Sandosh Padmanabhan and Brody, {Jennifer A.} and Rice, {Kenneth M.} and White, {Charles C.} and Tamara Harris and Aaron Isaacs and Harry Campbell and Lange, {Leslie A.} and Igor Rudan and Ivana Kolcic and Pau Navarro and Tatijana Zemunik and Veikko Salomaa and Samuli Ripatti and {CHARGE Lipids Working Grp}",
year = "2016",
month = "7",
doi = "10.1136/jmedgenet-2015-103439",
language = "English",
volume = "53",
pages = "441--449",
journal = "Journal of Medical Genetics",
issn = "0022-2593",
publisher = "BMJ Publishing Group Ltd",
number = "7",

}

van Leeuwen, EM, Sabo, A, Bis, JC, Huffman, JE, Manichaikul, A, Smith, AV, Feitosa, MF, Demissie, S, Joshi, PK, Duan, Q, Marten, J, van Klinken, JB, Surakka, I, Nolte, IM, Zhang, W, Mbarek, H, Li-Gao, R, Trompet, S, Verweij, N, Evangelou, E, Lyytikainen, L-P, Tayo, BO, Deelen, J, van der Most, PJ, van der Laan, SW, Arking, DE, Morrison, A, Dehghan, A, Franco, OH, Hofman, A, Rivadeneira, F, Sijbrands, EJ, Uitterlinden, AG, Mychaleckyj, JC, Campbell, A, Hocking, LJ, Padmanabhan, S, Brody, JA, Rice, KM, White, CC, Harris, T, Isaacs, A, Campbell, H, Lange, LA, Rudan, I, Kolcic, I, Navarro, P, Zemunik, T, Salomaa, V, Ripatti, S & CHARGE Lipids Working Grp 2016, 'Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels', Journal of Medical Genetics, vol. 53, no. 7, pp. 441-449. https://doi.org/10.1136/jmedgenet-2015-103439

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. / van Leeuwen, Elisabeth M.; Sabo, Aniko; Bis, Joshua C.; Huffman, Jennifer E.; Manichaikul, Ani; Smith, Albert V.; Feitosa, Mary F.; Demissie, Serkalem; Joshi, Peter K.; Duan, Qing; Marten, Jonathan; van Klinken, Jan B.; Surakka, Ida; Nolte, Ilja M.; Zhang, Weihua; Mbarek, Hamdi; Li-Gao, Ruifang; Trompet, Stella; Verweij, Niek; Evangelou, Evangelos; Lyytikainen, Leo-Pekka; Tayo, Bamidele O.; Deelen, Joris; van der Most, Peter J.; van der Laan, Sander W.; Arking, Dan E.; Morrison, Alanna; Dehghan, Abbas; Franco, Oscar H.; Hofman, Albert; Rivadeneira, Fernando; Sijbrands, Eric J.; Uitterlinden, Andre G.; Mychaleckyj, Josyf C.; Campbell, Archie; Hocking, Lynne J.; Padmanabhan, Sandosh; Brody, Jennifer A.; Rice, Kenneth M.; White, Charles C.; Harris, Tamara; Isaacs, Aaron; Campbell, Harry; Lange, Leslie A.; Rudan, Igor; Kolcic, Ivana; Navarro, Pau; Zemunik, Tatijana; Salomaa, Veikko; Ripatti, Samuli; CHARGE Lipids Working Grp.

In: Journal of Medical Genetics, Vol. 53, No. 7, 07.2016, p. 441-449.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

AU - van Leeuwen, Elisabeth M.

AU - Sabo, Aniko

AU - Bis, Joshua C.

AU - Huffman, Jennifer E.

AU - Manichaikul, Ani

AU - Smith, Albert V.

AU - Feitosa, Mary F.

AU - Demissie, Serkalem

AU - Joshi, Peter K.

AU - Duan, Qing

AU - Marten, Jonathan

AU - van Klinken, Jan B.

AU - Surakka, Ida

AU - Nolte, Ilja M.

AU - Zhang, Weihua

AU - Mbarek, Hamdi

AU - Li-Gao, Ruifang

AU - Trompet, Stella

AU - Verweij, Niek

AU - Evangelou, Evangelos

AU - Lyytikainen, Leo-Pekka

AU - Tayo, Bamidele O.

AU - Deelen, Joris

AU - van der Most, Peter J.

AU - van der Laan, Sander W.

AU - Arking, Dan E.

AU - Morrison, Alanna

AU - Dehghan, Abbas

AU - Franco, Oscar H.

AU - Hofman, Albert

AU - Rivadeneira, Fernando

AU - Sijbrands, Eric J.

AU - Uitterlinden, Andre G.

AU - Mychaleckyj, Josyf C.

AU - Campbell, Archie

AU - Hocking, Lynne J.

AU - Padmanabhan, Sandosh

AU - Brody, Jennifer A.

AU - Rice, Kenneth M.

AU - White, Charles C.

AU - Harris, Tamara

AU - Isaacs, Aaron

AU - Campbell, Harry

AU - Lange, Leslie A.

AU - Rudan, Igor

AU - Kolcic, Ivana

AU - Navarro, Pau

AU - Zemunik, Tatijana

AU - Salomaa, Veikko

AU - Ripatti, Samuli

AU - CHARGE Lipids Working Grp

PY - 2016/7

Y1 - 2016/7

KW - ELEMENT-BINDING PROTEIN

KW - GENE-EXPRESSION

KW - LIPID-SYNTHESIS

KW - GLUCOSE

KW - CHREBP

KW - MUTATIONS

KW - TRIGLYCERIDES

KW - TRANSCRIPTION

KW - SREBP-1C

KW - DISEASE

KW - 1184 Genetics, developmental biology, physiology

KW - 3142 Public health care science, environmental and occupational health

U2 - 10.1136/jmedgenet-2015-103439

DO - 10.1136/jmedgenet-2015-103439

M3 - Article

VL - 53

SP - 441

EP - 449

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

SN - 0022-2593

IS - 7

ER -