Meta-Analysis of Genome-Wide Association Studies in &gt; 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

Abbas Dehghan; Josee Dupuis; Maja Barbalic; Joshua C. Bis; Gudny Eiriksdottir; Chen Lu; Niina Pellikka; Henri Wallaschofski; Johannes Kettunen; Peter Henneman; Jens Baumert; David P. Strachan; Christian Fuchsberger; Veronique Vitart; James F. Wilson; Guillaume Pare; Silvia Naitza; Megan E. Rudock; Ida Surakka; Eco J. C. de Geus; Behrooz Z. Alizadeh; Jack Guralnik; Alan Shuldiner; Toshiko Tanaka; Robert Y. L. Zee; Renate B. Schnabel; Vijay Nambi; Maryam Kavousi; Samuli Ripatti; Matthias Nauck; Nicholas L. Smith; Albert V. Smith; Jouko Sundvall; Paul Scheet; Yongmei Liu; Aimo Ruokonen; Lynda M. Rose; Martin G. Larson; Ron C. Hoogeveen; Nelson B. Freimer; Alexander Teumer; Russell P. Tracy; Lenore J. Launer; Julie E. Buring; Jennifer F. Yamamoto; Aaron R. Folsom; Eric J. G. Sijbrands; James Pankow; Paul Elliott; John F. Keaney; Wei Sun; Antti-Pekka Sarin; Joao D. Fontes; Sunita Badola; Brad C. Astor; Albert Hofman; Anneli Pouta; Karl Werdan; Karin H. Greiser; Oliver Kuss; Henriette E. Meyer Zu Schwabedissen; Joachim Thiery; Yalda Jamshidi; Ilja M. Nolte; Nicole Soranzo; Timothy D. Spector; Henry Voelzke; Alexander N. Parker; Thor Aspelund; David Bates; Lauren Young; Kim Tsui; David S. Siscovick; Xiuqing Guo; Jerome I. Rotter; Manuela Uda; David Schlessinger; Igor Rudan; Andrew A. Hicks; Brenda W. Penninx; Barbara Thorand; Christian Gieger; Joe Coresh; Gonneke Willemsen; Tamara B. Harris; Andre G. Uitterlinden; Marjo-Riitta Jaervelin; Kenneth Rice; Doerte Radke; Veikko Salomaa; Ko Willems van Dijk; Eric Boerwinkle; Ramachandran S. Vasan; Luigi Ferrucci; Quince D. Gibson; Stefania Bandinelli; Harold Snieder; Dorret I. Boomsma; Xiangjun Xiao; Harry Campbell; Caroline Hayward; Peter P. Pramstaller; Cornelia M. van Duijn; Leena Peltonen; Bruce M. Psaty; Vilmundur Gudnason; Paul M. Ridker; Georg Homuth; Wolfgang Koenig; Christie M. Ballantyne; Jacqueline C. M. Witteman; Emelia J. Benjamin; Markus Perola; Daniel I. Chasman

doi:10.1161/CIRCULATIONAHA.110.948570

Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

Abbas Dehghan
, Josee Dupuis
, Maja Barbalic
, Joshua C. Bis
, Gudny Eiriksdottir
, Chen Lu
, Niina Pellikka
, Henri Wallaschofski
, Johannes Kettunen
, Peter Henneman
, Jens Baumert
, David P. Strachan
, Christian Fuchsberger
, Veronique Vitart
, James F. Wilson
, Guillaume Pare
, Silvia Naitza
, Megan E. Rudock
, Ida Surakka
, Eco J. C. de Geus

Behrooz Z. Alizadeh, Jack Guralnik, Alan Shuldiner, Toshiko Tanaka, Robert Y. L. Zee, Renate B. Schnabel, Vijay Nambi, Maryam Kavousi, Samuli Ripatti, Matthias Nauck, Nicholas L. Smith, Albert V. Smith, Jouko Sundvall, Paul Scheet, Yongmei Liu, Aimo Ruokonen, Lynda M. Rose, Martin G. Larson, Ron C. Hoogeveen, Nelson B. Freimer, Alexander Teumer, Russell P. Tracy, Lenore J. Launer, Julie E. Buring, Jennifer F. Yamamoto, Aaron R. Folsom, Eric J. G. Sijbrands, James Pankow, Paul Elliott, John F. Keaney, Wei Sun, Antti-Pekka Sarin, Joao D. Fontes, Sunita Badola, Brad C. Astor, Albert Hofman, Anneli Pouta, Karl Werdan, Karin H. Greiser, Oliver Kuss, Henriette E. Meyer Zu Schwabedissen, Joachim Thiery, Yalda Jamshidi, Ilja M. Nolte, Nicole Soranzo, Timothy D. Spector, Henry Voelzke, Alexander N. Parker, Thor Aspelund, David Bates, Lauren Young, Kim Tsui, David S. Siscovick, Xiuqing Guo, Jerome I. Rotter, Manuela Uda, David Schlessinger, Igor Rudan, Andrew A. Hicks, Brenda W. Penninx, Barbara Thorand, Christian Gieger, Joe Coresh, Gonneke Willemsen, Tamara B. Harris, Andre G. Uitterlinden, Marjo-Riitta Jaervelin, Kenneth Rice, Doerte Radke, Veikko Salomaa, Ko Willems van Dijk, Eric Boerwinkle, Ramachandran S. Vasan, Luigi Ferrucci, Quince D. Gibson, Stefania Bandinelli, Harold Snieder, Dorret I. Boomsma, Xiangjun Xiao, Harry Campbell, Caroline Hayward, Peter P. Pramstaller, Cornelia M. van Duijn, Leena Peltonen, Bruce M. Psaty, Vilmundur Gudnason, Paul M. Ridker, Georg Homuth, Wolfgang Koenig, Christie M. Ballantyne, Jacqueline C. M. Witteman, Emelia J. Benjamin, Markus Perola, Daniel I. Chasman

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Circulation
Volume	123
Issue number	7
Pages (from-to)	731-U151
Number of pages	91
ISSN	0009-7322
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.110.948570
Publication status	Published - 2011
MoE publication type	A1 Journal article-refereed

Fields of Science

genetics
inflammation
meta-analysis
myocardial infarction
genome-wide association study
CORONARY-HEART-DISEASE
GENETICALLY ISOLATED POPULATION
NETHERLANDS TWIN REGISTER
EPIDEMIOLOGIC APPLICATIONS
COMMON VARIANTS
ALPHA-GENE
CRP GENE
DESIGN
INFLAMMATION
FRAMINGHAM
1184 Genetics, developmental biology, physiology

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10.1161/CIRCULATIONAHA.110.948570

Cite this

Dehghan, A., Dupuis, J., Barbalic, M., Bis, J. C., Eiriksdottir, G., Lu, C., Pellikka, N., Wallaschofski, H., Kettunen, J., Henneman, P., Baumert, J., Strachan, D. P., Fuchsberger, C., Vitart, V., Wilson, J. F., Pare, G., Naitza, S., Rudock, M. E., Surakka, I., ... Chasman, D. I. (2011). Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels. Circulation , 123(7), 731-U151. https://doi.org/10.1161/CIRCULATIONAHA.110.948570

@article{9b1b6e445db54f38aab41e9199c6f9fb,

title = "Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels",

keywords = "genetics, inflammation, meta-analysis, myocardial infarction, genome-wide association study, CORONARY-HEART-DISEASE, GENETICALLY ISOLATED POPULATION, NETHERLANDS TWIN REGISTER, EPIDEMIOLOGIC APPLICATIONS, COMMON VARIANTS, ALPHA-GENE, CRP GENE, DESIGN, INFLAMMATION, FRAMINGHAM, 1184 Genetics, developmental biology, physiology",

author = "Abbas Dehghan and Josee Dupuis and Maja Barbalic and Bis, \{Joshua C.\} and Gudny Eiriksdottir and Chen Lu and Niina Pellikka and Henri Wallaschofski and Johannes Kettunen and Peter Henneman and Jens Baumert and Strachan, \{David P.\} and Christian Fuchsberger and Veronique Vitart and Wilson, \{James F.\} and Guillaume Pare and Silvia Naitza and Rudock, \{Megan E.\} and Ida Surakka and \{de Geus\}, \{Eco J. C.\} and Alizadeh, \{Behrooz Z.\} and Jack Guralnik and Alan Shuldiner and Toshiko Tanaka and Zee, \{Robert Y. L.\} and Schnabel, \{Renate B.\} and Vijay Nambi and Maryam Kavousi and Samuli Ripatti and Matthias Nauck and Smith, \{Nicholas L.\} and Smith, \{Albert V.\} and Jouko Sundvall and Paul Scheet and Yongmei Liu and Aimo Ruokonen and Rose, \{Lynda M.\} and Larson, \{Martin G.\} and Hoogeveen, \{Ron C.\} and Freimer, \{Nelson B.\} and Alexander Teumer and Tracy, \{Russell P.\} and Launer, \{Lenore J.\} and Buring, \{Julie E.\} and Yamamoto, \{Jennifer F.\} and Folsom, \{Aaron R.\} and Sijbrands, \{Eric J. G.\} and James Pankow and Paul Elliott and Keaney, \{John F.\} and Wei Sun and Antti-Pekka Sarin and Fontes, \{Joao D.\} and Sunita Badola and Astor, \{Brad C.\} and Albert Hofman and Anneli Pouta and Karl Werdan and Greiser, \{Karin H.\} and Oliver Kuss and Schwabedissen, \{Henriette E. Meyer Zu\} and Joachim Thiery and Yalda Jamshidi and Nolte, \{Ilja M.\} and Nicole Soranzo and Spector, \{Timothy D.\} and Henry Voelzke and Parker, \{Alexander N.\} and Thor Aspelund and David Bates and Lauren Young and Kim Tsui and Siscovick, \{David S.\} and Xiuqing Guo and Rotter, \{Jerome I.\} and Manuela Uda and David Schlessinger and Igor Rudan and Hicks, \{Andrew A.\} and Penninx, \{Brenda W.\} and Barbara Thorand and Christian Gieger and Joe Coresh and Gonneke Willemsen and Harris, \{Tamara B.\} and Uitterlinden, \{Andre G.\} and Marjo-Riitta Jaervelin and Kenneth Rice and Doerte Radke and Veikko Salomaa and \{van Dijk\}, \{Ko Willems\} and Eric Boerwinkle and Vasan, \{Ramachandran S.\} and Luigi Ferrucci and Gibson, \{Quince D.\} and Stefania Bandinelli and Harold Snieder and Boomsma, \{Dorret I.\} and Xiangjun Xiao and Harry Campbell and Caroline Hayward and Pramstaller, \{Peter P.\} and \{van Duijn\}, \{Cornelia M.\} and Leena Peltonen and Psaty, \{Bruce M.\} and Vilmundur Gudnason and Ridker, \{Paul M.\} and Georg Homuth and Wolfgang Koenig and Ballantyne, \{Christie M.\} and Witteman, \{Jacqueline C. M.\} and Benjamin, \{Emelia J.\} and Markus Perola and Chasman, \{Daniel I.\}",

year = "2011",

doi = "10.1161/CIRCULATIONAHA.110.948570",

language = "English",

volume = "123",

pages = "731--U151",

journal = "Circulation ",

issn = "0009-7322",

publisher = "Lippincott williams \& wilkins",

number = "7",

}

Dehghan, A, Dupuis, J, Barbalic, M, Bis, JC, Eiriksdottir, G, Lu, C, Pellikka, N, Wallaschofski, H, Kettunen, J, Henneman, P, Baumert, J, Strachan, DP, Fuchsberger, C, Vitart, V, Wilson, JF, Pare, G, Naitza, S, Rudock, ME, Surakka, I, de Geus, EJC, Alizadeh, BZ, Guralnik, J, Shuldiner, A, Tanaka, T, Zee, RYL, Schnabel, RB, Nambi, V, Kavousi, M, Ripatti, S, Nauck, M, Smith, NL, Smith, AV, Sundvall, J, Scheet, P, Liu, Y, Ruokonen, A, Rose, LM, Larson, MG, Hoogeveen, RC, Freimer, NB, Teumer, A, Tracy, RP, Launer, LJ, Buring, JE, Yamamoto, JF, Folsom, AR, Sijbrands, EJG, Pankow, J, Elliott, P, Keaney, JF, Sun, W, Sarin, A-P, Fontes, JD, Badola, S, Astor, BC, Hofman, A, Pouta, A, Werdan, K, Greiser, KH, Kuss, O, Schwabedissen, HEMZ, Thiery, J, Jamshidi, Y, Nolte, IM, Soranzo, N, Spector, TD, Voelzke, H, Parker, AN, Aspelund, T, Bates, D, Young, L, Tsui, K, Siscovick, DS, Guo, X, Rotter, JI, Uda, M, Schlessinger, D, Rudan, I, Hicks, AA, Penninx, BW, Thorand, B, Gieger, C, Coresh, J, Willemsen, G, Harris, TB, Uitterlinden, AG, Jaervelin, M-R, Rice, K, Radke, D, Salomaa, V, van Dijk, KW, Boerwinkle, E, Vasan, RS, Ferrucci, L, Gibson, QD, Bandinelli, S, Snieder, H, Boomsma, DI, Xiao, X, Campbell, H, Hayward, C, Pramstaller, PP, van Duijn, CM, Peltonen, L, Psaty, BM, Gudnason, V, Ridker, PM, Homuth, G, Koenig, W, Ballantyne, CM, Witteman, JCM, Benjamin, EJ, Perola, M & Chasman, DI 2011, 'Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels', Circulation , vol. 123, no. 7, pp. 731-U151. https://doi.org/10.1161/CIRCULATIONAHA.110.948570

TY - JOUR

T1 - Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

AU - Dehghan, Abbas

AU - Dupuis, Josee

AU - Barbalic, Maja

AU - Bis, Joshua C.

AU - Eiriksdottir, Gudny

AU - Lu, Chen

AU - Pellikka, Niina

AU - Wallaschofski, Henri

AU - Kettunen, Johannes

AU - Henneman, Peter

AU - Baumert, Jens

AU - Strachan, David P.

AU - Fuchsberger, Christian

AU - Vitart, Veronique

AU - Wilson, James F.

AU - Pare, Guillaume

AU - Naitza, Silvia

AU - Rudock, Megan E.

AU - Surakka, Ida

AU - de Geus, Eco J. C.

AU - Alizadeh, Behrooz Z.

AU - Guralnik, Jack

AU - Shuldiner, Alan

AU - Tanaka, Toshiko

AU - Zee, Robert Y. L.

AU - Schnabel, Renate B.

AU - Nambi, Vijay

AU - Kavousi, Maryam

AU - Ripatti, Samuli

AU - Nauck, Matthias

AU - Smith, Nicholas L.

AU - Smith, Albert V.

AU - Sundvall, Jouko

AU - Scheet, Paul

AU - Liu, Yongmei

AU - Ruokonen, Aimo

AU - Rose, Lynda M.

AU - Larson, Martin G.

AU - Hoogeveen, Ron C.

AU - Freimer, Nelson B.

AU - Teumer, Alexander

AU - Tracy, Russell P.

AU - Launer, Lenore J.

AU - Buring, Julie E.

AU - Yamamoto, Jennifer F.

AU - Folsom, Aaron R.

AU - Sijbrands, Eric J. G.

AU - Pankow, James

AU - Elliott, Paul

AU - Keaney, John F.

AU - Sun, Wei

AU - Sarin, Antti-Pekka

AU - Fontes, Joao D.

AU - Badola, Sunita

AU - Astor, Brad C.

AU - Hofman, Albert

AU - Pouta, Anneli

AU - Werdan, Karl

AU - Greiser, Karin H.

AU - Kuss, Oliver

AU - Schwabedissen, Henriette E. Meyer Zu

AU - Thiery, Joachim

AU - Jamshidi, Yalda

AU - Nolte, Ilja M.

AU - Soranzo, Nicole

AU - Spector, Timothy D.

AU - Voelzke, Henry

AU - Parker, Alexander N.

AU - Aspelund, Thor

AU - Bates, David

AU - Young, Lauren

AU - Tsui, Kim

AU - Siscovick, David S.

AU - Guo, Xiuqing

AU - Rotter, Jerome I.

AU - Uda, Manuela

AU - Schlessinger, David

AU - Rudan, Igor

AU - Hicks, Andrew A.

AU - Penninx, Brenda W.

AU - Thorand, Barbara

AU - Gieger, Christian

AU - Coresh, Joe

AU - Willemsen, Gonneke

AU - Harris, Tamara B.

AU - Uitterlinden, Andre G.

AU - Jaervelin, Marjo-Riitta

AU - Rice, Kenneth

AU - Radke, Doerte

AU - Salomaa, Veikko

AU - van Dijk, Ko Willems

AU - Boerwinkle, Eric

AU - Vasan, Ramachandran S.

AU - Ferrucci, Luigi

AU - Gibson, Quince D.

AU - Bandinelli, Stefania

AU - Snieder, Harold

AU - Boomsma, Dorret I.

AU - Xiao, Xiangjun

AU - Campbell, Harry

AU - Hayward, Caroline

AU - Pramstaller, Peter P.

AU - van Duijn, Cornelia M.

AU - Peltonen, Leena

AU - Psaty, Bruce M.

AU - Gudnason, Vilmundur

AU - Ridker, Paul M.

AU - Homuth, Georg

AU - Koenig, Wolfgang

AU - Ballantyne, Christie M.

AU - Witteman, Jacqueline C. M.

AU - Benjamin, Emelia J.

AU - Perola, Markus

AU - Chasman, Daniel I.

PY - 2011

Y1 - 2011

KW - genetics

KW - inflammation

KW - meta-analysis

KW - myocardial infarction

KW - genome-wide association study

KW - CORONARY-HEART-DISEASE

KW - GENETICALLY ISOLATED POPULATION

KW - NETHERLANDS TWIN REGISTER

KW - EPIDEMIOLOGIC APPLICATIONS

KW - COMMON VARIANTS

KW - ALPHA-GENE

KW - CRP GENE

KW - DESIGN

KW - INFLAMMATION

KW - FRAMINGHAM

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1161/CIRCULATIONAHA.110.948570

DO - 10.1161/CIRCULATIONAHA.110.948570

M3 - Article

SN - 0009-7322

VL - 123

SP - 731-U151

JO - Circulation

JF - Circulation

IS - 7

ER -

Meta-Analysis of Genome-Wide Association Studies in &gt; 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

Fields of Science

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Cite this

Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels