Metabolism of a Bioorthogonal PET Tracer Candidate [F-19/F-18]SiFA-Tetrazine in Mouse Liver Microsomes: Biotransformation Pathways and Defluorination Investigated by UHPLC-HRMS

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalMolecular Pharmaceutics
Volume17
Issue number8
Pages (from-to)3106-3115
Number of pages10
ISSN1543-8384
DOIs
Publication statusPublished - 3 Aug 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • defluorination
  • metabolism
  • positron emission tomography
  • silicon fluoride acceptor
  • tetrazine
  • geometric isomers
  • POSITRON-EMISSION-TOMOGRAPHY
  • IN-VITRO
  • BUILDING-BLOCKS
  • VIVO
  • PEPTIDES
  • PROBES
  • 116 Chemical sciences
  • 317 Pharmacy

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