Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Zydrune Polianskyte-Prause; Tuomas A. Tolvanen; Sonja Lindfors; Vincent Dumont; Mervi Van; Hong Wang; Surjya N. Dash; Mika Berg; Jette-Britt Naams; Laura C. Hautala; Harry Nisen; Tuomas Mirtti; Per-Henrik Groop; Kristiina Wähälä; Jukka Tienari; Sanna Lehtonen

doi:10.1096/fj.201800529RR

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Zydrune Polianskyte-Prause, Tuomas A. Tolvanen, Sonja Lindfors, Vincent Dumont, Mervi Van, Hong Wang, Surjya N. Dash, Mika Berg, Jette-Britt Naams, Laura C. Hautala, Harry Nisen, Tuomas Mirtti, Per-Henrik Groop, Kristiina Wähälä, Jukka Tienari, Sanna Lehtonen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	FASEB Journal
Volume	33
Issue number	2
Pages (from-to)	2858-2869
Number of pages	12
ISSN	0892-6638
DOIs	https://doi.org/10.1096/fj.201800529RR
Publication status	Published - Feb 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

diabetic kidney disease
insulin resistance
lipid phosphatase
podocyte
type 2 diabetes
ACTIVATED PROTEIN-KINASE
LIPID PHOSPHATASE SHIP2
INSULIN-RESISTANCE
PLASMA-MEMBRANE
METABOLISM
MECHANISM
PATHWAY
GLUT4
RAT
GLUCONEOGENESIS
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1096/fj.201800529RRLicence: CC BY

fj.201800529rrFinal published version, 1.98 MBLicence: CC BY

Cite this

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Dumont, V., Van, M., Wang, H., Dash, S. N., Berg, M., Naams, J.-B., Hautala, L. C., Nisen, H., Mirtti, T., Groop, P.-H., Wähälä, K., Tienari, J., & Lehtonen, S. (2019). Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. FASEB Journal, 33(2), 2858-2869. https://doi.org/10.1096/fj.201800529RR

@article{60c1752dac5743a6ade77350110c0451,

title = "Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity",

keywords = "diabetic kidney disease, insulin resistance, lipid phosphatase, podocyte, type 2 diabetes, ACTIVATED PROTEIN-KINASE, LIPID PHOSPHATASE SHIP2, INSULIN-RESISTANCE, PLASMA-MEMBRANE, METABOLISM, MECHANISM, PATHWAY, GLUT4, RAT, GLUCONEOGENESIS, 3121 General medicine, internal medicine and other clinical medicine",

author = "Zydrune Polianskyte-Prause and Tolvanen, {Tuomas A.} and Sonja Lindfors and Vincent Dumont and Mervi Van and Hong Wang and Dash, {Surjya N.} and Mika Berg and Jette-Britt Naams and Hautala, {Laura C.} and Harry Nisen and Tuomas Mirtti and Per-Henrik Groop and Kristiina W{\"a}h{\"a}l{\"a} and Jukka Tienari and Sanna Lehtonen",

year = "2019",

month = feb,

doi = "10.1096/fj.201800529RR",

language = "English",

volume = "33",

pages = "2858--2869",

journal = "FASEB Journal",

issn = "0892-6638",

publisher = "John Wiley & Sons Ltd. ",

number = "2",

}

Polianskyte-Prause, Z, Tolvanen, TA, Lindfors, S, Dumont, V, Van, M, Wang, H, Dash, SN, Berg, M, Naams, J-B , Hautala, LC , Nisen, H , Mirtti, T , Groop, P-H , Wähälä, K , Tienari, J & Lehtonen, S 2019, 'Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity', FASEB Journal, vol. 33, no. 2, pp. 2858-2869. https://doi.org/10.1096/fj.201800529RR

TY - JOUR

T1 - Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

AU - Polianskyte-Prause, Zydrune

AU - Tolvanen, Tuomas A.

AU - Lindfors, Sonja

AU - Dumont, Vincent

AU - Van, Mervi

AU - Wang, Hong

AU - Dash, Surjya N.

AU - Berg, Mika

AU - Naams, Jette-Britt

AU - Hautala, Laura C.

AU - Nisen, Harry

AU - Mirtti, Tuomas

AU - Groop, Per-Henrik

AU - Wähälä, Kristiina

AU - Tienari, Jukka

AU - Lehtonen, Sanna

PY - 2019/2

Y1 - 2019/2

KW - diabetic kidney disease

KW - insulin resistance

KW - lipid phosphatase

KW - podocyte

KW - type 2 diabetes

KW - ACTIVATED PROTEIN-KINASE

KW - LIPID PHOSPHATASE SHIP2

KW - INSULIN-RESISTANCE

KW - PLASMA-MEMBRANE

KW - METABOLISM

KW - MECHANISM

KW - PATHWAY

KW - GLUT4

KW - RAT

KW - GLUCONEOGENESIS

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1096/fj.201800529RR

DO - 10.1096/fj.201800529RR

M3 - Article

SN - 0892-6638

VL - 33

SP - 2858

EP - 2869

JO - FASEB Journal

JF - FASEB Journal

IS - 2

ER -