Microfluidic analysis techniques for safety assessment of pharmaceutical nano- and microsystems

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

This chapter reviews the evolution of microfabrication methods and materials, applicable to manufacturing of micro total analysis systems (or lab‐on‐a‐chip), from a general perspective. It discusses the possibilities and limitations associated with microfluidic cell culturing, or so called organ‐on‐a‐chip technology, together with selected examples of their exploitation to characterization of pharmaceutical nano‐ and microsystems. Materials selection plays a pivotal role in terms of ensuring the cell adhesion and viability as well as defining the prevailing culture conditions inside the microfluidic channels. The chapter focuses on the hepatic safety assessment of nanoparticles and gives an overview of the development of microfluidic immobilized enzyme reactors that could facilitate examination of the hepatic effects of nanomedicines under physiologically relevant conditions. It also provides an overview of the future prospects regarding system‐level integration possibilities facilitated by microfabrication of miniaturized separation and sample preparation systems as integral parts of microfluidic in vitro models.
Original languageEnglish
Title of host publicationCharacterization of Pharmaceutical Nano- and Microsystems
EditorsLeena Peltonen
Number of pages38
Place of PublicationHoboken
PublisherJohn Wiley & Sons Ltd.
Publication date19 Jan 2021
Pages97-135
ISBN (Print)9781119414049
ISBN (Electronic)9781119414018
DOIs
Publication statusPublished - 19 Jan 2021
MoE publication typeA3 Book chapter

Publication series

NameAdvances in Pharmaceutical Technology
PublisherJohn Wiley & Sons, Ltd.

Fields of Science

  • 116 Chemical sciences
  • 221 Nano-technology
  • microfluidics
  • microfabrication
  • organ-on-a-ship
  • immobilized enzyme reactors
  • microship electrophoresis
  • drug metabolism

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