Chapter 7 - Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems

Yuezhou Zhang, Dongfei Liu, Hongbo Zhang, Helder Almeida Santos

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review


Nanotechnology-based therapeutics, operating at scales of billionths of a meter, hold great potentials in altering the methods and efficiency of drug delivery. However, a major bottleneck in the application of nanoparticulate drug delivery systems is their slow translation to the industrial practice, attributed to the quality control and inadequate productivity of the conventional preparing methods. In contrast, microfluidics fabricates nanoparticles in a well-tailored, reproducible, and high-throughput manner, therefore hold great potentials to address the barrier to translate laboratory nanomedicine formulations to industrial applications. This chapter overviews the microfluidic devices developed to prepare nanoparticulate drug delivery systems, covering Y- and T-shaped mixing, digital microfluidic droplet generator, hydrodynamic flow focusing, confined impinging jets mixer, multiinlet vortex mixer, and gas-liquid segmented microfluidics. Altogether, the microfluidic technique offers a promising alternative to industrialize nanoparticulate drug delivery systems.
Original languageEnglish
Title of host publicationMicrofluidics for Pharmaceutical Applications : From Nano/Micro Systems Fabrication to Controlled Drug Delivery
EditorsHelder A. Santos, Dongfei Liu, Hongbo Zhang
Number of pages23
Place of PublicationSan Diego
Publication date2019
ISBN (Print)978-0-12-812659-2
ISBN (Electronic)978-0-12-812660-8
Publication statusPublished - 2019
MoE publication typeA3 Book chapter

Publication series

NameMicro and Nano Technologies

Fields of Science

  • 221 Nano-technology
  • 317 Pharmacy

Cite this