Microtechnologies to fuel neurobiological research with nanometer precision

Cecilia Brunello, Ville Jokinen, Prasanna Sakha, Hideyuki Terazono, Fumimasa Nomura, Tomoyuki Kaneko, Sari Lauri, Sami Franssila, Claudio Rivera Baeza, Kenji Yasuda, Henri Juhani Huttunen

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

The interface between engineering and molecular life sciences has been fertile ground for advancing our understanding of complex biological systems. Engineered microstructures offer a diverse toolbox for cellular and molecular biologists to direct the placement of cells and small organisms, and to recreate biological functions in vitro: cells can be positioned and connected in a designed fashion, and connectivity and community effects of cells studied. Because of the highly polar morphology and finely compartmentalized functions of neurons, microfabricated cell culture systems and related on-chip technologies have become an important enabling platform for studying development, function and degeneration of the nervous system at the molecular and cellular level. Here we review some of the compartmentalization techniques developed so far to highlight how high- precision control of neuronal connectivity allows new approaches for studying axonal and synaptic biology.
Original languageEnglish
Article number11
JournalJournal of Nanobiotechnology
Volume11
Issue numberApril
Number of pages8
ISSN1477-3155
DOIs
Publication statusPublished - 10 Apr 2013
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 3112 Neurosciences

Cite this

Brunello, Cecilia ; Jokinen, Ville ; Sakha, Prasanna ; Terazono, Hideyuki ; Nomura, Fumimasa ; Kaneko, Tomoyuki ; Lauri, Sari ; Franssila, Sami ; Rivera Baeza, Claudio ; Yasuda, Kenji ; Huttunen, Henri Juhani. / Microtechnologies to fuel neurobiological research with nanometer precision. In: Journal of Nanobiotechnology. 2013 ; Vol. 11, No. April.
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abstract = "The interface between engineering and molecular life sciences has been fertile ground for advancing our understanding of complex biological systems. Engineered microstructures offer a diverse toolbox for cellular and molecular biologists to direct the placement of cells and small organisms, and to recreate biological functions in vitro: cells can be positioned and connected in a designed fashion, and connectivity and community effects of cells studied. Because of the highly polar morphology and finely compartmentalized functions of neurons, microfabricated cell culture systems and related on-chip technologies have become an important enabling platform for studying development, function and degeneration of the nervous system at the molecular and cellular level. Here we review some of the compartmentalization techniques developed so far to highlight how high- precision control of neuronal connectivity allows new approaches for studying axonal and synaptic biology.",
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Microtechnologies to fuel neurobiological research with nanometer precision. / Brunello, Cecilia; Jokinen, Ville; Sakha, Prasanna; Terazono, Hideyuki; Nomura, Fumimasa; Kaneko, Tomoyuki; Lauri, Sari; Franssila, Sami; Rivera Baeza, Claudio; Yasuda, Kenji; Huttunen, Henri Juhani.

In: Journal of Nanobiotechnology, Vol. 11, No. April, 11, 10.04.2013.

Research output: Contribution to journalReview ArticleScientificpeer-review

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T1 - Microtechnologies to fuel neurobiological research with nanometer precision

AU - Brunello, Cecilia

AU - Jokinen, Ville

AU - Sakha, Prasanna

AU - Terazono, Hideyuki

AU - Nomura, Fumimasa

AU - Kaneko, Tomoyuki

AU - Lauri, Sari

AU - Franssila, Sami

AU - Rivera Baeza, Claudio

AU - Yasuda, Kenji

AU - Huttunen, Henri Juhani

PY - 2013/4/10

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N2 - The interface between engineering and molecular life sciences has been fertile ground for advancing our understanding of complex biological systems. Engineered microstructures offer a diverse toolbox for cellular and molecular biologists to direct the placement of cells and small organisms, and to recreate biological functions in vitro: cells can be positioned and connected in a designed fashion, and connectivity and community effects of cells studied. Because of the highly polar morphology and finely compartmentalized functions of neurons, microfabricated cell culture systems and related on-chip technologies have become an important enabling platform for studying development, function and degeneration of the nervous system at the molecular and cellular level. Here we review some of the compartmentalization techniques developed so far to highlight how high- precision control of neuronal connectivity allows new approaches for studying axonal and synaptic biology.

AB - The interface between engineering and molecular life sciences has been fertile ground for advancing our understanding of complex biological systems. Engineered microstructures offer a diverse toolbox for cellular and molecular biologists to direct the placement of cells and small organisms, and to recreate biological functions in vitro: cells can be positioned and connected in a designed fashion, and connectivity and community effects of cells studied. Because of the highly polar morphology and finely compartmentalized functions of neurons, microfabricated cell culture systems and related on-chip technologies have become an important enabling platform for studying development, function and degeneration of the nervous system at the molecular and cellular level. Here we review some of the compartmentalization techniques developed so far to highlight how high- precision control of neuronal connectivity allows new approaches for studying axonal and synaptic biology.

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