Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

Joni Nikkanen; Saara Forsstrom; Liliya Euro; Ilse Paetau; Rebecca A. Kohnz; Liya Wang; Dmitri Chilov; Jenni Viinamaki; Anne Roivainen; Paivi Marjamaki; Heidi Liljenback; Sofia Ahola; Jana Buzkova; Mugen Terzioglu; Nahid A. Khan; Sini Pirnes-Karhu; Anders Paetau; Tuula Lonnqvist; Antti Sajantila; Pirjo Isohanni; Henna Tyynismaa; Daniel K. Nomura; Brendan J. Battersby; Vidya Velagapudi; Christopher J. Carroll; Anu Suomalainen

doi:10.1016/j.cmet.2016.01.019

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

Joni Nikkanen
, Saara Forsstrom
, Liliya Euro
, Ilse Paetau
, Rebecca A. Kohnz
, Liya Wang
, Dmitri Chilov
, Jenni Viinamaki
, Anne Roivainen
, Paivi Marjamaki
, Heidi Liljenback
, Sofia Ahola
, Jana Buzkova
, Mugen Terzioglu
, Nahid A. Khan
, Sini Pirnes-Karhu
, Anders Paetau
, Tuula Lonnqvist
, Antti Sajantila
, Pirjo Isohanni

Henna Tyynismaa, Daniel K. Nomura, Brendan J. Battersby, Vidya Velagapudi, Christopher J. Carroll, Anu Suomalainen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Cell Metabolism
Volume	23
Issue number	4
Pages (from-to)	635-648
Number of pages	14
ISSN	1550-4131
DOIs	https://doi.org/10.1016/j.cmet.2016.01.019
Publication status	Published - 12 Apr 2016
MoE publication type	A1 Journal article-refereed

Fields of Science

PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA
ONSET SPINOCEREBELLAR ATAXIA
MULTIPLE DELETIONS
CRYSTAL-STRUCTURE
RECESSIVE ATAXIA
BACTERIOPHAGE T7
MTDNA DEPLETION
HELICASE
MUTATIONS
TWINKLE
3111 Biomedicine
3112 Neurosciences
3124 Neurology and psychiatry

Access to Document

10.1016/j.cmet.2016.01.019

FIMM Metabolomics (LS-RIA/ Metabo-HiLIFE)
Nieminen, A. I. (Manager)
Institute for Molecular Medicine Finland
Facility/equipment: Core Facility

Cite this

Nikkanen, J., Forsstrom, S., Euro, L., Paetau, I., Kohnz, R. A., Wang, L., Chilov, D., Viinamaki, J., Roivainen, A., Marjamaki, P., Liljenback, H., Ahola, S., Buzkova, J., Terzioglu, M., Khan, N. A., Pirnes-Karhu, S., Paetau, A., Lonnqvist, T., Sajantila, A., ... Suomalainen, A. (2016). Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism. Cell Metabolism, 23(4), 635-648. https://doi.org/10.1016/j.cmet.2016.01.019

@article{aba5a826e01a4c09a513588d4dd9269e,

title = "Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism",

keywords = "PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA, ONSET SPINOCEREBELLAR ATAXIA, MULTIPLE DELETIONS, CRYSTAL-STRUCTURE, RECESSIVE ATAXIA, BACTERIOPHAGE T7, MTDNA DEPLETION, HELICASE, MUTATIONS, TWINKLE, 3111 Biomedicine, 3112 Neurosciences, 3124 Neurology and psychiatry",

author = "Joni Nikkanen and Saara Forsstrom and Liliya Euro and Ilse Paetau and Kohnz, \{Rebecca A.\} and Liya Wang and Dmitri Chilov and Jenni Viinamaki and Anne Roivainen and Paivi Marjamaki and Heidi Liljenback and Sofia Ahola and Jana Buzkova and Mugen Terzioglu and Khan, \{Nahid A.\} and Sini Pirnes-Karhu and Anders Paetau and Tuula Lonnqvist and Antti Sajantila and Pirjo Isohanni and Henna Tyynismaa and Nomura, \{Daniel K.\} and Battersby, \{Brendan J.\} and Vidya Velagapudi and Carroll, \{Christopher J.\} and Anu Suomalainen",

year = "2016",

month = apr,

day = "12",

doi = "10.1016/j.cmet.2016.01.019",

language = "English",

volume = "23",

pages = "635--648",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "4",

}

Nikkanen, J, Forsstrom, S , Euro, L , Paetau, I, Kohnz, RA, Wang, L, Chilov, D, Viinamaki, J, Roivainen, A, Marjamaki, P, Liljenback, H, Ahola, S, Buzkova, J, Terzioglu, M, Khan, NA, Pirnes-Karhu, S, Paetau, A, Lonnqvist, T, Sajantila, A , Isohanni, P , Tyynismaa, H, Nomura, DK, Battersby, BJ, Velagapudi, V, Carroll, CJ & Suomalainen, A 2016, 'Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism', Cell Metabolism, vol. 23, no. 4, pp. 635-648. https://doi.org/10.1016/j.cmet.2016.01.019

TY - JOUR

T1 - Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

AU - Nikkanen, Joni

AU - Forsstrom, Saara

AU - Euro, Liliya

AU - Paetau, Ilse

AU - Kohnz, Rebecca A.

AU - Wang, Liya

AU - Chilov, Dmitri

AU - Viinamaki, Jenni

AU - Roivainen, Anne

AU - Marjamaki, Paivi

AU - Liljenback, Heidi

AU - Ahola, Sofia

AU - Buzkova, Jana

AU - Terzioglu, Mugen

AU - Khan, Nahid A.

AU - Pirnes-Karhu, Sini

AU - Paetau, Anders

AU - Lonnqvist, Tuula

AU - Sajantila, Antti

AU - Isohanni, Pirjo

AU - Tyynismaa, Henna

AU - Nomura, Daniel K.

AU - Battersby, Brendan J.

AU - Velagapudi, Vidya

AU - Carroll, Christopher J.

AU - Suomalainen, Anu

PY - 2016/4/12

Y1 - 2016/4/12

KW - PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA

KW - ONSET SPINOCEREBELLAR ATAXIA

KW - MULTIPLE DELETIONS

KW - CRYSTAL-STRUCTURE

KW - RECESSIVE ATAXIA

KW - BACTERIOPHAGE T7

KW - MTDNA DEPLETION

KW - HELICASE

KW - MUTATIONS

KW - TWINKLE

KW - 3111 Biomedicine

KW - 3112 Neurosciences

KW - 3124 Neurology and psychiatry

U2 - 10.1016/j.cmet.2016.01.019

DO - 10.1016/j.cmet.2016.01.019

M3 - Article

SN - 1550-4131

VL - 23

SP - 635

EP - 648

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

Fields of Science

Access to Document

Equipment

FIMM Metabolomics (LS-RIA/ Metabo-HiLIFE)

Cite this