Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism

Tommi Vatanen; Karolina S. Jabbar; Terhi Ruohtula; Jarno Honkanen; Julian Avila-Pacheco; Heli Siljander; Martin Stražar; Sami Oikarinen; Heikki Hyöty; Jorma Ilonen; Caroline M. Mitchell; Moran Yassour; Suvi M. Virtanen; Clary B. Clish; Damian R. Plichta; Hera Vlamakis; Mikael Knip; Ramnik J. Xavier

doi:10.1016/j.cell.2022.11.023

Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism

Tommi Vatanen, Karolina S. Jabbar, Terhi Ruohtula, Jarno Honkanen, Julian Avila-Pacheco, Heli Siljander, Martin Stražar, Sami Oikarinen, Heikki Hyöty, Jorma Ilonen, Caroline M. Mitchell, Moran Yassour, Suvi M. Virtanen, Clary B. Clish, Damian R. Plichta, Hera Vlamakis, Mikael Knip, Ramnik J. Xavier

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Cell
Volume	185
Issue number	26
Pages (from-to)	4921-4936.e15
Number of pages	32
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2022.11.023
Publication status	Published - 22 Dec 2022
MoE publication type	A1 Journal article-refereed

Bibliographical note

Funding Information:
We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health ( P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation ( 2-SRA-2016-247-S-B ), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research.

Funding Information:
We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health (P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation (2-SRA-2016-247-S-B), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. T.V. H.V. M.K. and R.J.X. served as principal investigators. T.V. and K.S.J. analyzed metagenomic data. T.V. K.S.J. J.A.-P. M.S. C.B.C. and D.R.P. analyzed metabolomic data. T.R. analyzed intestinal biomarkers. J.H. analyzed cytokines. T.R. J.H. H.S. S.O. H.H. J.I. S.M.V. and M.K. contributed to collection of stool and blood samples and patient information. M.Y. and C.M.M. collected breast milk samples. T.V. K.S.J. D.R.P. H.V. and R.J.X. drafted the manuscript. All authors discussed the results, critically reviewed the text, and approved the final manuscript. R.J.X. is co-founder of Jnana Therapeutics and Celsius Therapeutics, board director at MoonLake Immunotherapeutics, and consultant to Nestlé; these organizations had no role in the study.

Publisher Copyright:
© 2022 Elsevier Inc.

Fields of Science

gut metabolome
horizontal gene transfer
infant gut microbiome
mother-to-infant microbiome transmission
3111 Biomedicine
1182 Biochemistry, cell and molecular biology

Access to Document

10.1016/j.cell.2022.11.023

Cite this

Vatanen, T., Jabbar, K. S., Ruohtula, T., Honkanen, J., Avila-Pacheco, J., Siljander, H., Stražar, M., Oikarinen, S., Hyöty, H., Ilonen, J., Mitchell, C. M., Yassour, M., Virtanen, S. M., Clish, C. B., Plichta, D. R., Vlamakis, H., Knip, M., & Xavier, R. J. (2022). Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism. Cell, 185(26), 4921-4936.e15. https://doi.org/10.1016/j.cell.2022.11.023

@article{b361273f28e64eaba116e5c6f415caea,

title = "Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism",

keywords = "gut metabolome, horizontal gene transfer, infant gut microbiome, mother-to-infant microbiome transmission, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology",

author = "Tommi Vatanen and Jabbar, {Karolina S.} and Terhi Ruohtula and Jarno Honkanen and Julian Avila-Pacheco and Heli Siljander and Martin Stra{\v z}ar and Sami Oikarinen and Heikki Hy{\"o}ty and Jorma Ilonen and Mitchell, {Caroline M.} and Moran Yassour and Virtanen, {Suvi M.} and Clish, {Clary B.} and Plichta, {Damian R.} and Hera Vlamakis and Mikael Knip and Xavier, {Ramnik J.}",

note = "Funding Information: We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health ( P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation ( 2-SRA-2016-247-S-B ), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. Funding Information: We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health (P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation (2-SRA-2016-247-S-B), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. T.V. H.V. M.K. and R.J.X. served as principal investigators. T.V. and K.S.J. analyzed metagenomic data. T.V. K.S.J. J.A.-P. M.S. C.B.C. and D.R.P. analyzed metabolomic data. T.R. analyzed intestinal biomarkers. J.H. analyzed cytokines. T.R. J.H. H.S. S.O. H.H. J.I. S.M.V. and M.K. contributed to collection of stool and blood samples and patient information. M.Y. and C.M.M. collected breast milk samples. T.V. K.S.J. D.R.P. H.V. and R.J.X. drafted the manuscript. All authors discussed the results, critically reviewed the text, and approved the final manuscript. R.J.X. is co-founder of Jnana Therapeutics and Celsius Therapeutics, board director at MoonLake Immunotherapeutics, and consultant to Nestl{\'e}; these organizations had no role in the study. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = dec,

day = "22",

doi = "10.1016/j.cell.2022.11.023",

language = "English",

volume = "185",

pages = "4921--4936.e15",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "26",

}

Vatanen, T, Jabbar, KS, Ruohtula, T , Honkanen, J, Avila-Pacheco, J, Siljander, H, Stražar, M, Oikarinen, S, Hyöty, H, Ilonen, J, Mitchell, CM, Yassour, M, Virtanen, SM, Clish, CB, Plichta, DR, Vlamakis, H, Knip, M & Xavier, RJ 2022, 'Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism', Cell, vol. 185, no. 26, pp. 4921-4936.e15. https://doi.org/10.1016/j.cell.2022.11.023

TY - JOUR

T1 - Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism

AU - Vatanen, Tommi

AU - Jabbar, Karolina S.

AU - Ruohtula, Terhi

AU - Honkanen, Jarno

AU - Avila-Pacheco, Julian

AU - Siljander, Heli

AU - Stražar, Martin

AU - Oikarinen, Sami

AU - Hyöty, Heikki

AU - Ilonen, Jorma

AU - Mitchell, Caroline M.

AU - Yassour, Moran

AU - Virtanen, Suvi M.

AU - Clish, Clary B.

AU - Plichta, Damian R.

AU - Vlamakis, Hera

AU - Knip, Mikael

AU - Xavier, Ramnik J.

N1 - Funding Information: We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health ( P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation ( 2-SRA-2016-247-S-B ), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. Funding Information: We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health (P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation (2-SRA-2016-247-S-B), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. T.V. H.V. M.K. and R.J.X. served as principal investigators. T.V. and K.S.J. analyzed metagenomic data. T.V. K.S.J. J.A.-P. M.S. C.B.C. and D.R.P. analyzed metabolomic data. T.R. analyzed intestinal biomarkers. J.H. analyzed cytokines. T.R. J.H. H.S. S.O. H.H. J.I. S.M.V. and M.K. contributed to collection of stool and blood samples and patient information. M.Y. and C.M.M. collected breast milk samples. T.V. K.S.J. D.R.P. H.V. and R.J.X. drafted the manuscript. All authors discussed the results, critically reviewed the text, and approved the final manuscript. R.J.X. is co-founder of Jnana Therapeutics and Celsius Therapeutics, board director at MoonLake Immunotherapeutics, and consultant to Nestlé; these organizations had no role in the study. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/12/22

Y1 - 2022/12/22

KW - gut metabolome

KW - horizontal gene transfer

KW - infant gut microbiome

KW - mother-to-infant microbiome transmission

KW - 3111 Biomedicine

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1016/j.cell.2022.11.023

DO - 10.1016/j.cell.2022.11.023

M3 - Article

C2 - 36563663

AN - SCOPUS:85144246023

VL - 185

SP - 4921-4936.e15

JO - Cell

JF - Cell

SN - 0092-8674

IS - 26

ER -