Modified VEGF-A with improved angiogenic properties

Kari Kustaa Alitalo, Tuomas Leo Herman Tammela, Salla Elina Keskitalo, Katri Marianna Pajusola, Markku Michael Jeltsch, Seppo Ylä-Herttuala, Terhi Hannele Kärpänen, Ulf Eriksson, Marko Juha Tapani Uutela

Research output: PatentScientific

Abstract

The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
Original languageEnglish
Publication Year27 Sep 2011
Publication statusPublished - 27 Sep 2011
MoE publication typeH1 Granted patent

Cite this

Alitalo, K. K., Tammela, T. L. H., Keskitalo, S. E., Pajusola, K. M., Jeltsch, M. M., Ylä-Herttuala, S., ... Uutela, M. J. T. (2011). Modified VEGF-A with improved angiogenic properties. (Patent No. US 8,025,886 B2). US Patent and Trademark Office.
Alitalo, Kari Kustaa (Author) ; Tammela, Tuomas Leo Herman (Author) ; Keskitalo, Salla Elina (Author) ; Pajusola, Katri Marianna (Author) ; Jeltsch, Markku Michael (Author) ; Ylä-Herttuala, Seppo (Author) ; Kärpänen, Terhi Hannele (Author) ; Eriksson, Ulf (Author) ; Uutela, Marko Juha Tapani (Author). / Modified VEGF-A with improved angiogenic properties. US Patent and Trademark Office. Patent No.: US 8,025,886 B2. Sep 27, 2011.
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title = "Modified VEGF-A with improved angiogenic properties",
abstract = "The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.",
author = "Alitalo, {Kari Kustaa} and Tammela, {Tuomas Leo Herman} and Keskitalo, {Salla Elina} and Pajusola, {Katri Marianna} and Jeltsch, {Markku Michael} and Seppo Yl{\"a}-Herttuala and K{\"a}rp{\"a}nen, {Terhi Hannele} and Ulf Eriksson and Uutela, {Marko Juha Tapani}",
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month = "9",
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publisher = "US Patent and Trademark Office",
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Alitalo, KK, Tammela, TLH, Keskitalo, SE, Pajusola, KM, Jeltsch, MM, Ylä-Herttuala, S, Kärpänen, TH, Eriksson, U & Uutela, MJT Sep. 27 2011, Modified VEGF-A with improved angiogenic properties, Patent No. US 8,025,886 B2.

Modified VEGF-A with improved angiogenic properties. / Alitalo, Kari Kustaa; Tammela, Tuomas Leo Herman; Keskitalo, Salla Elina; Pajusola, Katri Marianna; Jeltsch, Markku Michael; Ylä-Herttuala, Seppo; Kärpänen, Terhi Hannele; Eriksson, Ulf; Uutela, Marko Juha Tapani.

US Patent and Trademark Office. Patent No.: US 8,025,886 B2. Sep 27, 2011.

Research output: PatentScientific

TY - PAT

T1 - Modified VEGF-A with improved angiogenic properties

AU - Alitalo, Kari Kustaa

AU - Tammela, Tuomas Leo Herman

AU - Keskitalo, Salla Elina

AU - Pajusola, Katri Marianna

AU - Jeltsch, Markku Michael

AU - Ylä-Herttuala, Seppo

AU - Kärpänen, Terhi Hannele

AU - Eriksson, Ulf

AU - Uutela, Marko Juha Tapani

PY - 2011/9/27

Y1 - 2011/9/27

N2 - The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.

AB - The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.

M3 - Patent

M1 - US 8,025,886 B2

Y2 - 2011/09/27

PB - US Patent and Trademark Office

ER -

Alitalo KK, Tammela TLH, Keskitalo SE, Pajusola KM, Jeltsch MM, Ylä-Herttuala S et al. Modified VEGF-A with improved angiogenic properties. US 8,025,886 B2. 2011 Sep 27.