Modified VEGF-A with improved angiogenic properties

Kari Kustaa Alitalo, Tuomas Leo Herman Tammela, Salla Elina Keskitalo, Katri Marianna Pajusola, Markku Michael Jeltsch, Seppo Ylä-Herttuala, Terhi Hannele Kärpänen, Ulf Eriksson, Marko Juha Tapani Uutela

Research output: Patent


The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
Original languageEnglish
Publication Year27 Sep 2011
Publication statusPublished - 27 Sep 2011
MoE publication typeH1 Granted patent

Cite this

Alitalo, K. K., Tammela, T. L. H., Keskitalo, S. E., Pajusola, K. M., Jeltsch, M. M., Ylä-Herttuala, S., ... Uutela, M. J. T. (2011). Modified VEGF-A with improved angiogenic properties. (Patent No. US 8,025,886 B2). US Patent and Trademark Office.