Monoclonal antibodies selective for alpha-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and alpha-synuclein transgenic mice with the disease-causing A30P mutation

Therese Fagerqvist; Veronica Lindstrom; Eva Nordstrom; Anna Lord; Stina M. E. Tucker; Xingjian Su; Charlotte Sahlin; Alex Kasrayan; Jessica Andersson; Hedvig Welander; Thomas Nasstrom; Mats Holmquist; Heinrich Schell; Philipp J. Kahle; Hannu Kalimo; Christer Moller; Par Gellerfors; Lars Lannfelt; Joakim Bergstrom; Martin Ingelsson

doi:10.1111/jnc.12175

Monoclonal antibodies selective for alpha-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and alpha-synuclein transgenic mice with the disease-causing A30P mutation

Therese Fagerqvist, Veronica Lindstrom, Eva Nordstrom, Anna Lord, Stina M. E. Tucker, Xingjian Su, Charlotte Sahlin, Alex Kasrayan, Jessica Andersson, Hedvig Welander, Thomas Nasstrom, Mats Holmquist, Heinrich Schell, Philipp J. Kahle, Hannu Kalimo, Christer Moller, Par Gellerfors, Lars Lannfelt, Joakim Bergstrom, Martin Ingelsson

Department of Pathology

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Journal of Neurochemistry
Volume	126
Issue number	1
Pages (from-to)	131-144
Number of pages	14
ISSN	0022-3042
DOIs	https://doi.org/10.1111/jnc.12175
Publication status	Published - Jul 2013
MoE publication type	A1 Journal article-refereed

Fields of Science

alpha-synuclein
dementia with Lewy bodies
monoclonal antibody
oligomer
Parkinson's disease
protofibril
PARKINSONS-DISEASE
IN-VIVO
CEREBROSPINAL-FLUID
SOLUBLE OLIGOMERS
FIBRIL FORMATION
ELEVATED LEVELS
CROSS-LINKING
AGGREGATION
BODIES
PROTOFIBRILS
3111 Biomedicine

Access to Document

10.1111/jnc.12175

Cite this

Fagerqvist, T., Lindstrom, V., Nordstrom, E., Lord, A., Tucker, S. M. E., Su, X., Sahlin, C., Kasrayan, A., Andersson, J., Welander, H., Nasstrom, T., Holmquist, M., Schell, H., Kahle, P. J., Kalimo, H., Moller, C., Gellerfors, P., Lannfelt, L., Bergstrom, J., & Ingelsson, M. (2013). Monoclonal antibodies selective for alpha-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and alpha-synuclein transgenic mice with the disease-causing A30P mutation. Journal of Neurochemistry, 126(1), 131-144. https://doi.org/10.1111/jnc.12175

@article{a4293486958d422c9067f17b1988d4ff,

title = "Monoclonal antibodies selective for alpha-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and alpha-synuclein transgenic mice with the disease-causing A30P mutation",

keywords = "alpha-synuclein, dementia with Lewy bodies, monoclonal antibody, oligomer, Parkinson's disease, protofibril, PARKINSONS-DISEASE, IN-VIVO, CEREBROSPINAL-FLUID, SOLUBLE OLIGOMERS, FIBRIL FORMATION, ELEVATED LEVELS, CROSS-LINKING, AGGREGATION, BODIES, PROTOFIBRILS, 3111 Biomedicine",

author = "Therese Fagerqvist and Veronica Lindstrom and Eva Nordstrom and Anna Lord and Tucker, \{Stina M. E.\} and Xingjian Su and Charlotte Sahlin and Alex Kasrayan and Jessica Andersson and Hedvig Welander and Thomas Nasstrom and Mats Holmquist and Heinrich Schell and Kahle, \{Philipp J.\} and Hannu Kalimo and Christer Moller and Par Gellerfors and Lars Lannfelt and Joakim Bergstrom and Martin Ingelsson",

year = "2013",

month = jul,

doi = "10.1111/jnc.12175",

language = "English",

volume = "126",

pages = "131--144",

journal = "Journal of Neurochemistry",

issn = "0022-3042",

publisher = "John Wiley and Sons Inc",

number = "1",

}

Fagerqvist, T, Lindstrom, V, Nordstrom, E, Lord, A, Tucker, SME, Su, X, Sahlin, C, Kasrayan, A, Andersson, J, Welander, H, Nasstrom, T, Holmquist, M, Schell, H, Kahle, PJ, Kalimo, H, Moller, C, Gellerfors, P, Lannfelt, L, Bergstrom, J & Ingelsson, M 2013, 'Monoclonal antibodies selective for alpha-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and alpha-synuclein transgenic mice with the disease-causing A30P mutation', Journal of Neurochemistry, vol. 126, no. 1, pp. 131-144. https://doi.org/10.1111/jnc.12175

Monoclonal antibodies selective for alpha-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and alpha-synuclein transgenic mice with the disease-causing A30P mutation. / Fagerqvist, Therese; Lindstrom, Veronica; Nordstrom, Eva et al.
In: Journal of Neurochemistry, Vol. 126, No. 1, 07.2013, p. 131-144.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Monoclonal antibodies selective for alpha-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and alpha-synuclein transgenic mice with the disease-causing A30P mutation

AU - Fagerqvist, Therese

AU - Lindstrom, Veronica

AU - Nordstrom, Eva

AU - Lord, Anna

AU - Tucker, Stina M. E.

AU - Su, Xingjian

AU - Sahlin, Charlotte

AU - Kasrayan, Alex

AU - Andersson, Jessica

AU - Welander, Hedvig

AU - Nasstrom, Thomas

AU - Holmquist, Mats

AU - Schell, Heinrich

AU - Kahle, Philipp J.

AU - Kalimo, Hannu

AU - Moller, Christer

AU - Gellerfors, Par

AU - Lannfelt, Lars

AU - Bergstrom, Joakim

AU - Ingelsson, Martin

PY - 2013/7

Y1 - 2013/7

KW - alpha-synuclein

KW - dementia with Lewy bodies

KW - monoclonal antibody

KW - oligomer

KW - Parkinson's disease

KW - protofibril

KW - PARKINSONS-DISEASE

KW - IN-VIVO

KW - CEREBROSPINAL-FLUID

KW - SOLUBLE OLIGOMERS

KW - FIBRIL FORMATION

KW - ELEVATED LEVELS

KW - CROSS-LINKING

KW - AGGREGATION

KW - BODIES

KW - PROTOFIBRILS

KW - 3111 Biomedicine

U2 - 10.1111/jnc.12175

DO - 10.1111/jnc.12175

M3 - Article

SN - 0022-3042

VL - 126

SP - 131

EP - 144

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 1

ER -