Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Zehua Liu, Yunzhan Li, Wei Li, Chen Xiao, Dongfei Liu, Chao Dong, Ming Zhang, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni T. Hirvonen, Hongbo Zhang, Dawang Zhou, Xianming Deng, Helder A. Santos

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver one drug and increase the computer tomography (CT) signal for acute-liver-failure (ALF) theranostics. A microfluidic-assisted method is used to co-encapsulate different NPs in a single step. By alternating the surface properties of different NPs and by modulating the composition of the organic phase, both PSi and Au NPs are effectively encapsulated into the polymer matrix simultaneously, thus further achieving a multifunctional application. This system can be used to identify pathologically changes in the tissues and selectively deliver drugs to these sites. The loading of a therapeutic compound (XMU-MP-1) improves the drug solubility, precise, in situ drug delivery, and the drug-functioning time. In vivo results confirm a superior treatment effect and better compliance of this newly developed nanoformulation than free compound. This nanosystem plays a crucial role in targeting the lesion area, thus increasing the local drug concentration important for ALF reverse-effect. Moreover, the residence of Au NPs within the matrix further endows our system for CT-imaging. Altogether, these results support that this nanohybrid is a potential theranostic platform for ALF.
Original languageEnglish
Article number1703393
JournalAdvanced Materials
Volume30
Issue number24
Number of pages10
ISSN0935-9648
DOIs
Publication statusPublished - 13 Jun 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 317 Pharmacy
  • liver regeneration
  • nanohybrids
  • nanoparticles
  • porous silicon
  • theranostic
  • IN-VITRO
  • COMPUTED-TOMOGRAPHY
  • IMAGING APPEARANCE
  • CANCER-THERAPY
  • DELIVERY
  • INFLAMMATION
  • NANOCOMPOSITES
  • RECRUITMENT
  • DIAGNOSIS
  • FIBROSIS
  • 116 Chemical sciences
  • 221 Nano-technology
  • 216 Materials engineering

Cite this

@article{6ee842e64ecd47a3a8e931da5d7c707a,
title = "Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics",
abstract = "Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver one drug and increase the computer tomography (CT) signal for acute-liver-failure (ALF) theranostics. A microfluidic-assisted method is used to co-encapsulate different NPs in a single step. By alternating the surface properties of different NPs and by modulating the composition of the organic phase, both PSi and Au NPs are effectively encapsulated into the polymer matrix simultaneously, thus further achieving a multifunctional application. This system can be used to identify pathologically changes in the tissues and selectively deliver drugs to these sites. The loading of a therapeutic compound (XMU-MP-1) improves the drug solubility, precise, in situ drug delivery, and the drug-functioning time. In vivo results confirm a superior treatment effect and better compliance of this newly developed nanoformulation than free compound. This nanosystem plays a crucial role in targeting the lesion area, thus increasing the local drug concentration important for ALF reverse-effect. Moreover, the residence of Au NPs within the matrix further endows our system for CT-imaging. Altogether, these results support that this nanohybrid is a potential theranostic platform for ALF.",
keywords = "317 Pharmacy, liver regeneration, nanohybrids, nanoparticles, porous silicon, theranostic, IN-VITRO, COMPUTED-TOMOGRAPHY, IMAGING APPEARANCE, CANCER-THERAPY, DELIVERY, INFLAMMATION, NANOCOMPOSITES, RECRUITMENT, DIAGNOSIS, FIBROSIS, 116 Chemical sciences, 221 Nano-technology, 216 Materials engineering",
author = "Zehua Liu and Yunzhan Li and Wei Li and Chen Xiao and Dongfei Liu and Chao Dong and Ming Zhang and Ermei M{\"a}kil{\"a} and Marianna Kemell and Jarno Salonen and Hirvonen, {Jouni T.} and Hongbo Zhang and Dawang Zhou and Xianming Deng and Santos, {Helder A.}",
year = "2018",
month = "6",
day = "13",
doi = "10.1002/adma.201703393",
language = "English",
volume = "30",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH",
number = "24",

}

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics. / Liu, Zehua; Li, Yunzhan ; Li, Wei; Xiao, Chen; Liu, Dongfei; Dong, Chao ; Zhang, Ming ; Mäkilä, Ermei; Kemell, Marianna; Salonen, Jarno; Hirvonen, Jouni T.; Zhang, Hongbo; Zhou, Dawang ; Deng, Xianming ; Santos, Helder A.

In: Advanced Materials, Vol. 30, No. 24, 1703393 , 13.06.2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

AU - Liu, Zehua

AU - Li, Yunzhan

AU - Li, Wei

AU - Xiao, Chen

AU - Liu, Dongfei

AU - Dong, Chao

AU - Zhang, Ming

AU - Mäkilä, Ermei

AU - Kemell, Marianna

AU - Salonen, Jarno

AU - Hirvonen, Jouni T.

AU - Zhang, Hongbo

AU - Zhou, Dawang

AU - Deng, Xianming

AU - Santos, Helder A.

PY - 2018/6/13

Y1 - 2018/6/13

N2 - Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver one drug and increase the computer tomography (CT) signal for acute-liver-failure (ALF) theranostics. A microfluidic-assisted method is used to co-encapsulate different NPs in a single step. By alternating the surface properties of different NPs and by modulating the composition of the organic phase, both PSi and Au NPs are effectively encapsulated into the polymer matrix simultaneously, thus further achieving a multifunctional application. This system can be used to identify pathologically changes in the tissues and selectively deliver drugs to these sites. The loading of a therapeutic compound (XMU-MP-1) improves the drug solubility, precise, in situ drug delivery, and the drug-functioning time. In vivo results confirm a superior treatment effect and better compliance of this newly developed nanoformulation than free compound. This nanosystem plays a crucial role in targeting the lesion area, thus increasing the local drug concentration important for ALF reverse-effect. Moreover, the residence of Au NPs within the matrix further endows our system for CT-imaging. Altogether, these results support that this nanohybrid is a potential theranostic platform for ALF.

AB - Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver one drug and increase the computer tomography (CT) signal for acute-liver-failure (ALF) theranostics. A microfluidic-assisted method is used to co-encapsulate different NPs in a single step. By alternating the surface properties of different NPs and by modulating the composition of the organic phase, both PSi and Au NPs are effectively encapsulated into the polymer matrix simultaneously, thus further achieving a multifunctional application. This system can be used to identify pathologically changes in the tissues and selectively deliver drugs to these sites. The loading of a therapeutic compound (XMU-MP-1) improves the drug solubility, precise, in situ drug delivery, and the drug-functioning time. In vivo results confirm a superior treatment effect and better compliance of this newly developed nanoformulation than free compound. This nanosystem plays a crucial role in targeting the lesion area, thus increasing the local drug concentration important for ALF reverse-effect. Moreover, the residence of Au NPs within the matrix further endows our system for CT-imaging. Altogether, these results support that this nanohybrid is a potential theranostic platform for ALF.

KW - 317 Pharmacy

KW - liver regeneration

KW - nanohybrids

KW - nanoparticles

KW - porous silicon

KW - theranostic

KW - IN-VITRO

KW - COMPUTED-TOMOGRAPHY

KW - IMAGING APPEARANCE

KW - CANCER-THERAPY

KW - DELIVERY

KW - INFLAMMATION

KW - NANOCOMPOSITES

KW - RECRUITMENT

KW - DIAGNOSIS

KW - FIBROSIS

KW - 116 Chemical sciences

KW - 221 Nano-technology

KW - 216 Materials engineering

U2 - 10.1002/adma.201703393

DO - 10.1002/adma.201703393

M3 - Article

VL - 30

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 24

M1 - 1703393

ER -