Multifunctional Porous Silicon for Therapeutic Drug Delivery and Imaging

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Major challenges in drug formulation are the poor solid state stability of drug molecules, poor dissolution/ solubility and/or poor pharmacokinetic properties (bioavailability), which may lead to unreliable in vitro-in vivo (IVIV) correlation. To improve current therapeutical strategies, novel means to deliver poorly water soluble active pharmaceutical ingredients, as well as to target them to specific sites or cells in the body are needed. Biomedical applications of porous silicon (PSi) have been actively investigated during the last 10 years, especially in the areas of drug delivery and imaging, due to the biocompatibility and biodegradability of PSi materials, which makes them a potential candidate for controlled drug release. In addition, the unique pore sizes and easily functionalized surface properties of PSi materials allow high drug payloads and controlled kinetics from the drug release formulations. Modification of the PSi surface properties also facilitates biofunctionalization of the surface and the possibility to attach targeting moieties (e.g., antibodies and peptides), thus enabling effective targeting of the payload. In this review, we briefly address the production methodologies of PSi, and we will mainly present and discuss several examples about the biocompatibility of PSi, the most recent in vitro and in vivo applications of PSi as a carrier in drug/protein/peptide delivery and tissue engineering, as well as PSi as a platform for drug targeting and imaging.
Original languageEnglish
JournalCurrent Drug Discovery Technologies
Volume8
Issue number3
Pages (from-to)228-249
Number of pages22
ISSN1570-1638
Publication statusPublished - Sep 2011
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy

Cite this

@article{24d23b0dbebe438f98a35e4dc93e4d8b,
title = "Multifunctional Porous Silicon for Therapeutic Drug Delivery and Imaging",
abstract = "Major challenges in drug formulation are the poor solid state stability of drug molecules, poor dissolution/ solubility and/or poor pharmacokinetic properties (bioavailability), which may lead to unreliable in vitro-in vivo (IVIV) correlation. To improve current therapeutical strategies, novel means to deliver poorly water soluble active pharmaceutical ingredients, as well as to target them to specific sites or cells in the body are needed. Biomedical applications of porous silicon (PSi) have been actively investigated during the last 10 years, especially in the areas of drug delivery and imaging, due to the biocompatibility and biodegradability of PSi materials, which makes them a potential candidate for controlled drug release. In addition, the unique pore sizes and easily functionalized surface properties of PSi materials allow high drug payloads and controlled kinetics from the drug release formulations. Modification of the PSi surface properties also facilitates biofunctionalization of the surface and the possibility to attach targeting moieties (e.g., antibodies and peptides), thus enabling effective targeting of the payload. In this review, we briefly address the production methodologies of PSi, and we will mainly present and discuss several examples about the biocompatibility of PSi, the most recent in vitro and in vivo applications of PSi as a carrier in drug/protein/peptide delivery and tissue engineering, as well as PSi as a platform for drug targeting and imaging.",
keywords = "317 Pharmacy",
author = "Santos, {H{\'e}lder A.} and Bimbo, {Luis Maria} and Vesa-Pekka Lehto and Anu Airaksinen and Jarno Salonen and Jouni Hirvonen",
year = "2011",
month = "9",
language = "English",
volume = "8",
pages = "228--249",
journal = "Current Drug Discovery Technologies",
issn = "1570-1638",
publisher = "Bentham Science Publishers, Ltd.",
number = "3",

}

Multifunctional Porous Silicon for Therapeutic Drug Delivery and Imaging. / Santos, Hélder A.; Bimbo, Luis Maria; Lehto, Vesa-Pekka ; Airaksinen, Anu; Salonen, Jarno ; Hirvonen, Jouni.

In: Current Drug Discovery Technologies, Vol. 8, No. 3, 09.2011, p. 228-249.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Multifunctional Porous Silicon for Therapeutic Drug Delivery and Imaging

AU - Santos, Hélder A.

AU - Bimbo, Luis Maria

AU - Lehto, Vesa-Pekka

AU - Airaksinen, Anu

AU - Salonen, Jarno

AU - Hirvonen, Jouni

PY - 2011/9

Y1 - 2011/9

N2 - Major challenges in drug formulation are the poor solid state stability of drug molecules, poor dissolution/ solubility and/or poor pharmacokinetic properties (bioavailability), which may lead to unreliable in vitro-in vivo (IVIV) correlation. To improve current therapeutical strategies, novel means to deliver poorly water soluble active pharmaceutical ingredients, as well as to target them to specific sites or cells in the body are needed. Biomedical applications of porous silicon (PSi) have been actively investigated during the last 10 years, especially in the areas of drug delivery and imaging, due to the biocompatibility and biodegradability of PSi materials, which makes them a potential candidate for controlled drug release. In addition, the unique pore sizes and easily functionalized surface properties of PSi materials allow high drug payloads and controlled kinetics from the drug release formulations. Modification of the PSi surface properties also facilitates biofunctionalization of the surface and the possibility to attach targeting moieties (e.g., antibodies and peptides), thus enabling effective targeting of the payload. In this review, we briefly address the production methodologies of PSi, and we will mainly present and discuss several examples about the biocompatibility of PSi, the most recent in vitro and in vivo applications of PSi as a carrier in drug/protein/peptide delivery and tissue engineering, as well as PSi as a platform for drug targeting and imaging.

AB - Major challenges in drug formulation are the poor solid state stability of drug molecules, poor dissolution/ solubility and/or poor pharmacokinetic properties (bioavailability), which may lead to unreliable in vitro-in vivo (IVIV) correlation. To improve current therapeutical strategies, novel means to deliver poorly water soluble active pharmaceutical ingredients, as well as to target them to specific sites or cells in the body are needed. Biomedical applications of porous silicon (PSi) have been actively investigated during the last 10 years, especially in the areas of drug delivery and imaging, due to the biocompatibility and biodegradability of PSi materials, which makes them a potential candidate for controlled drug release. In addition, the unique pore sizes and easily functionalized surface properties of PSi materials allow high drug payloads and controlled kinetics from the drug release formulations. Modification of the PSi surface properties also facilitates biofunctionalization of the surface and the possibility to attach targeting moieties (e.g., antibodies and peptides), thus enabling effective targeting of the payload. In this review, we briefly address the production methodologies of PSi, and we will mainly present and discuss several examples about the biocompatibility of PSi, the most recent in vitro and in vivo applications of PSi as a carrier in drug/protein/peptide delivery and tissue engineering, as well as PSi as a platform for drug targeting and imaging.

KW - 317 Pharmacy

M3 - Review Article

VL - 8

SP - 228

EP - 249

JO - Current Drug Discovery Technologies

JF - Current Drug Discovery Technologies

SN - 1570-1638

IS - 3

ER -