Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain

Aino-Liisa Mutka, Aleksi Haapanen, Reijo Käkelä, Maria Lindfors, Ann K. Wright, Teija Inkinen, Martin Hermansson, Anne Rokka, Garry Corthals, Matti Jauhiainen, Thomas H. Gillingwater, Elina Ikonen, Jaana Tyynelä

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Neurochemistry
Volume112
Issue number1
Pages (from-to)193-203
Number of pages11
ISSN0022-3042
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fields of Science

  • cathepsin D
  • lipidomics
  • mouse model
  • myelin
  • proteomics
  • ultrastructure
  • NEURONAL-CEROID-LIPOFUSCINOSIS
  • IONIZATION MASS-SPECTROMETRY
  • CENTRAL-NERVOUS-SYSTEM
  • MYELIN BASIC-PROTEIN
  • APOLIPOPROTEIN-E
  • ALZHEIMERS-DISEASE
  • PLASMALOGEN DEFICIENCY
  • LYSOSOMAL STORAGE
  • IN-VIVO
  • MICE
  • 311 Basic medicine

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