Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

Kailu Yang; Chuchu Wang; Alex J.B. Kreutzberger; Ravi Ojha; Suvi Kuivanen; Sergio Couoh-Cardel; Serena Muratcioglu; Timothy J. Eisen; K. Ian White; Richard G. Held; Subu Subramanian; Kendra Marcus; Richard A. Pfuetzner; Luis Esquivies; Catherine A. Doyle; John Kuriyan; Olli Vapalahti; Giuseppe Balistreri; Tom Kirchhausen; Axel T. Brunger

doi:10.1073/pnas.2210990119

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

Kailu Yang, Chuchu Wang, Alex J.B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen, K. Ian White, Richard G. Held, Subu Subramanian, Kendra Marcus, Richard A. Pfuetzner, Luis Esquivies, Catherine A. Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T. Brunger

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	e2210990119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	40
Number of pages	11
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.2210990119
Publication status	Published - 4 Oct 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

HR2
inhibitor
membrane fusion
peptide
SARS-CoV-2
11832 Microbiology and virology
3111 Biomedicine

Access to Document

10.1073/pnas.2210990119Licence: CC BY-NC-ND

Nanomolar inhibitionFinal published version, 2.49 MBLicence: CC BY-NC-ND

Cite this

Yang, K., Wang, C., Kreutzberger, A. J. B., Ojha, R., Kuivanen, S., Couoh-Cardel, S., Muratcioglu, S., Eisen, T. J., White, K. I., Held, R. G., Subramanian, S., Marcus, K., Pfuetzner, R. A., Esquivies, L., Doyle, C. A., Kuriyan, J., Vapalahti, O., Balistreri, G., Kirchhausen, T., & Brunger, A. T. (2022). Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. Proceedings of the National Academy of Sciences of the United States of America, 119(40), Article e2210990119. https://doi.org/10.1073/pnas.2210990119

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title = "Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein",

keywords = "HR2, inhibitor, membrane fusion, peptide, SARS-CoV-2, 11832 Microbiology and virology, 3111 Biomedicine",

author = "Kailu Yang and Chuchu Wang and Kreutzberger, {Alex J.B.} and Ravi Ojha and Suvi Kuivanen and Sergio Couoh-Cardel and Serena Muratcioglu and Eisen, {Timothy J.} and White, {K. Ian} and Held, {Richard G.} and Subu Subramanian and Kendra Marcus and Pfuetzner, {Richard A.} and Luis Esquivies and Doyle, {Catherine A.} and John Kuriyan and Olli Vapalahti and Giuseppe Balistreri and Tom Kirchhausen and Brunger, {Axel T.}",

year = "2022",

month = oct,

day = "4",

doi = "10.1073/pnas.2210990119",

language = "English",

volume = "119",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

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Yang, K, Wang, C, Kreutzberger, AJB, Ojha, R , Kuivanen, S, Couoh-Cardel, S, Muratcioglu, S, Eisen, TJ, White, KI, Held, RG, Subramanian, S, Marcus, K, Pfuetzner, RA, Esquivies, L, Doyle, CA, Kuriyan, J, Vapalahti, O , Balistreri, G, Kirchhausen, T & Brunger, AT 2022, 'Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 40, e2210990119. https://doi.org/10.1073/pnas.2210990119

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. / Yang, Kailu; Wang, Chuchu; Kreutzberger, Alex J.B. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 40, e2210990119, 04.10.2022.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

AU - Yang, Kailu

AU - Wang, Chuchu

AU - Kreutzberger, Alex J.B.

AU - Ojha, Ravi

AU - Kuivanen, Suvi

AU - Couoh-Cardel, Sergio

AU - Muratcioglu, Serena

AU - Eisen, Timothy J.

AU - White, K. Ian

AU - Held, Richard G.

AU - Subramanian, Subu

AU - Marcus, Kendra

AU - Pfuetzner, Richard A.

AU - Esquivies, Luis

AU - Doyle, Catherine A.

AU - Kuriyan, John

AU - Vapalahti, Olli

AU - Balistreri, Giuseppe

AU - Kirchhausen, Tom

AU - Brunger, Axel T.

PY - 2022/10/4

Y1 - 2022/10/4

KW - HR2

KW - inhibitor

KW - membrane fusion

KW - peptide

KW - SARS-CoV-2

KW - 11832 Microbiology and virology

KW - 3111 Biomedicine

U2 - 10.1073/pnas.2210990119

DO - 10.1073/pnas.2210990119

M3 - Article

C2 - 36122200

AN - SCOPUS:85138195504

SN - 0027-8424

VL - 119

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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M1 - e2210990119

ER -