Abstract
The small interfering RNA (siRNA)‐based therapeutics have raised great attention since the first RNA interference (RNAi)‐derived drug, patisiran, was approved by the US Food and Drug Administration, which represented a landmark in the field of gene therapy. Given the properties of interfering disease‐associated gene expression, RNAi machinery is regarded as an essential factor for preparing precise medicine. However, over the past few years, siRNA drugs are undergoing a period of clinical translation, in which the major hurdle is the limited efficient delivery strategies. Therefore, this mini‐review mainly focuses on describing the state‐of‐the‐art of the nanoscale platforms for delivering siRNA payloads, also addressing their applications in cancer therapy. Finally, the status of siRNA drugs under clinical trials is discussed, providing a comprehensive understanding on the field of oligonucleotide‐mediated therapeutics.
Original language | English |
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Article number | 20200111 |
Journal | View |
Volume | 2 |
Issue number | 3 |
Number of pages | 12 |
ISSN | 2688-3988 |
DOIs | |
Publication status | Published - Jun 2021 |
MoE publication type | A2 Review article in a scientific journal |
Fields of Science
- BLOCKADE
- EFFICACY
- ENDOSOMAL ESCAPE
- FIBROBLASTS
- FIBROSIS
- LIPID NANOPARTICLES
- MACROPHAGES
- RNA
- STRATEGY
- TUMOR MICROENVIRONMENT
- cancer therapy
- nanomedicine
- nanoparticles
- small interfering RNA
- 318 Medical biotechnology
- 317 Pharmacy
- 3122 Cancers