The object of this study was to investigate the improvement in the dissolution and solubility behavior between various nanoparticle size fractions of a poorly soluble model drug, indomethacin (IND). Nanocrystalsuspensions were prepared by using the top-down, wet milling technique with three different stabilizers: poloxamer F68, poloxamer F127 and polysorbate (Tween) 80. The dissolution and solubility behavior of different particle size fractions was investigated using a channel flow method and a novel UV imaging system. Unmilled bulk indomethacin and physical mixture were used as references. According to both methods solubility properties of indomethacin were improved clearly by the particle size reduction. UV imaging was used in this study for the first time in the solubility testing of fast dissolving nanoscale samples. Technique provided new information about the concentration of the dissolved drug next to the sample surface: with the smallest nanocrystals the concentration next to the particle surface exceeded even sixfold the thermodynamic saturated solution concentration. This means that the solubility improvement itself, not only the increased dissolution area, has crucial role in higher dissolution rates of nanoparticle formulations. Along the method development the UV imaging offers an advantageous technique to study nanoscale samples more in detail.
|Place of Publication||Helsinki|
|Publication status||Published - 2012|
|MoE publication type||G2 Master's thesis, polytechnic Master's thesis|
Fields of Science
- 221 Nano-technology
- 317 Pharmacy