Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria.

Elke Dittmann, Muriel Gugger, Anna Kaarina Sivonen, David Peter Fewer

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Cyanobacteria are an ancient lineage of slow-growing photosynthetic bacteria and a prolific source of natural products with intricate chemical structures and potent biological activities. The bulk of these natural products are known from just a handful of genera. Recent efforts have elucidated the mechanisms underpinning the biosynthesis of a diverse array of natural products from cyanobacteria. Many of the biosynthetic mechanisms are unique to cyanobacteria or rarely described from other organisms. Advances in genome sequence technology have precipitated a deluge of genome sequences for cyanobacteria. This makes it possible to link known natural products to biosynthetic gene clusters but also accelerates the discovery of new natural products through genome mining. These studies demonstrate that cyanobacteria encode a huge variety of cryptic gene clusters for the production of natural products, and the known chemical diversity is likely to be just a fraction of the true biosynthetic capabilities of this fascinating and ancient group of organisms.
Original languageEnglish
JournalTrends in Microbiology
Volume23
Issue number10
Pages (from-to)642-652
Number of pages11
ISSN0966-842X
DOIs
Publication statusPublished - 5 Oct 2015
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 1183 Plant biology, microbiology, virology

Cite this

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abstract = "Cyanobacteria are an ancient lineage of slow-growing photosynthetic bacteria and a prolific source of natural products with intricate chemical structures and potent biological activities. The bulk of these natural products are known from just a handful of genera. Recent efforts have elucidated the mechanisms underpinning the biosynthesis of a diverse array of natural products from cyanobacteria. Many of the biosynthetic mechanisms are unique to cyanobacteria or rarely described from other organisms. Advances in genome sequence technology have precipitated a deluge of genome sequences for cyanobacteria. This makes it possible to link known natural products to biosynthetic gene clusters but also accelerates the discovery of new natural products through genome mining. These studies demonstrate that cyanobacteria encode a huge variety of cryptic gene clusters for the production of natural products, and the known chemical diversity is likely to be just a fraction of the true biosynthetic capabilities of this fascinating and ancient group of organisms.",
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Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria. / Dittmann, Elke; Gugger, Muriel; Sivonen, Anna Kaarina; Fewer, David Peter.

In: Trends in Microbiology, Vol. 23, No. 10, 05.10.2015, p. 642-652.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria.

AU - Dittmann, Elke

AU - Gugger, Muriel

AU - Sivonen, Anna Kaarina

AU - Fewer, David Peter

PY - 2015/10/5

Y1 - 2015/10/5

N2 - Cyanobacteria are an ancient lineage of slow-growing photosynthetic bacteria and a prolific source of natural products with intricate chemical structures and potent biological activities. The bulk of these natural products are known from just a handful of genera. Recent efforts have elucidated the mechanisms underpinning the biosynthesis of a diverse array of natural products from cyanobacteria. Many of the biosynthetic mechanisms are unique to cyanobacteria or rarely described from other organisms. Advances in genome sequence technology have precipitated a deluge of genome sequences for cyanobacteria. This makes it possible to link known natural products to biosynthetic gene clusters but also accelerates the discovery of new natural products through genome mining. These studies demonstrate that cyanobacteria encode a huge variety of cryptic gene clusters for the production of natural products, and the known chemical diversity is likely to be just a fraction of the true biosynthetic capabilities of this fascinating and ancient group of organisms.

AB - Cyanobacteria are an ancient lineage of slow-growing photosynthetic bacteria and a prolific source of natural products with intricate chemical structures and potent biological activities. The bulk of these natural products are known from just a handful of genera. Recent efforts have elucidated the mechanisms underpinning the biosynthesis of a diverse array of natural products from cyanobacteria. Many of the biosynthetic mechanisms are unique to cyanobacteria or rarely described from other organisms. Advances in genome sequence technology have precipitated a deluge of genome sequences for cyanobacteria. This makes it possible to link known natural products to biosynthetic gene clusters but also accelerates the discovery of new natural products through genome mining. These studies demonstrate that cyanobacteria encode a huge variety of cryptic gene clusters for the production of natural products, and the known chemical diversity is likely to be just a fraction of the true biosynthetic capabilities of this fascinating and ancient group of organisms.

KW - 1183 Plant biology, microbiology, virology

U2 - 10.1016/j.tim.2015.07.008

DO - 10.1016/j.tim.2015.07.008

M3 - Review Article

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JO - Trends in Microbiology

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