Neurofibrillary tau pathology modulated by genetic variation of [alpha]-synuclein

Terhi Peuralinna, Minna Oinas, Tuomo Polvikoski, Anders Paetau, Raimo Sulkava, Leena Niinistö, Hannu Kalimo, Dena Hernandez, John Hardy, Andrew Singleton, Pentti J Tienari, Liisa Myllykangas

Research output: Contribution to journalArticleScientificpeer-review


"We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical P-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration."
Original languageEnglish
JournalAnnals of Neurology
Issue number3
Pages (from-to)348-352
Number of pages5
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Cite this