Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats

Susanne Back, Julie Necarsulmer, Leslie R. Whitaker, Lamarque M. Coke, Pyry Koivula, Emily J. Heathward, Lowella Fortuno, Yajun Zhang, C. Grace Yeh, Heather A. Baldwin, Morgan D. Spencer, Carlos A. Mejias-Aponte, James Pickel, Alexander F. Hoffman, Charles E. Spivak, Carl R. Lupica, Suzanne M. Underhill, Susan G. Amara, Andrii Domanskyi, Jenni E. Anttila & 5 others Mikko Airavaara, Bruce T. Hope, F. Kent Hamra, Christopher T. Richie, Brandon K. Harvey

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNeuron
Volume102
Issue number1
Pages (from-to)105-+
Number of pages23
ISSN0896-6273
DOIs
Publication statusPublished - 3 Apr 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • HOMOLOGY-DIRECTED REPAIR
  • ONE-STEP GENERATION
  • NEUROTROPHIC FACTOR
  • DOPAMINE RELEASE
  • MICE
  • RNA
  • CAS9
  • CRISPR/CAS9
  • EXPRESSION
  • MODELS
  • 3112 Neurosciences

Cite this

Back, S., Necarsulmer, J., Whitaker, L. R., Coke, L. M., Koivula, P., Heathward, E. J., ... Harvey, B. K. (2019). Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron, 102(1), 105-+. https://doi.org/10.1016/j.neuron.2019.01.035
Back, Susanne ; Necarsulmer, Julie ; Whitaker, Leslie R. ; Coke, Lamarque M. ; Koivula, Pyry ; Heathward, Emily J. ; Fortuno, Lowella ; Zhang, Yajun ; Yeh, C. Grace ; Baldwin, Heather A. ; Spencer, Morgan D. ; Mejias-Aponte, Carlos A. ; Pickel, James ; Hoffman, Alexander F. ; Spivak, Charles E. ; Lupica, Carl R. ; Underhill, Suzanne M. ; Amara, Susan G. ; Domanskyi, Andrii ; Anttila, Jenni E. ; Airavaara, Mikko ; Hope, Bruce T. ; Hamra, F. Kent ; Richie, Christopher T. ; Harvey, Brandon K. / Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. In: Neuron. 2019 ; Vol. 102, No. 1. pp. 105-+.
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title = "Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats",
keywords = "HOMOLOGY-DIRECTED REPAIR, ONE-STEP GENERATION, NEUROTROPHIC FACTOR, DOPAMINE RELEASE, MICE, RNA, CAS9, CRISPR/CAS9, EXPRESSION, MODELS, 3112 Neurosciences",
author = "Susanne Back and Julie Necarsulmer and Whitaker, {Leslie R.} and Coke, {Lamarque M.} and Pyry Koivula and Heathward, {Emily J.} and Lowella Fortuno and Yajun Zhang and Yeh, {C. Grace} and Baldwin, {Heather A.} and Spencer, {Morgan D.} and Mejias-Aponte, {Carlos A.} and James Pickel and Hoffman, {Alexander F.} and Spivak, {Charles E.} and Lupica, {Carl R.} and Underhill, {Suzanne M.} and Amara, {Susan G.} and Andrii Domanskyi and Anttila, {Jenni E.} and Mikko Airavaara and Hope, {Bruce T.} and Hamra, {F. Kent} and Richie, {Christopher T.} and Harvey, {Brandon K.}",
year = "2019",
month = "4",
day = "3",
doi = "10.1016/j.neuron.2019.01.035",
language = "English",
volume = "102",
pages = "105--+",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",

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Back, S, Necarsulmer, J, Whitaker, LR, Coke, LM, Koivula, P, Heathward, EJ, Fortuno, L, Zhang, Y, Yeh, CG, Baldwin, HA, Spencer, MD, Mejias-Aponte, CA, Pickel, J, Hoffman, AF, Spivak, CE, Lupica, CR, Underhill, SM, Amara, SG, Domanskyi, A, Anttila, JE, Airavaara, M, Hope, BT, Hamra, FK, Richie, CT & Harvey, BK 2019, 'Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats' Neuron, vol. 102, no. 1, pp. 105-+. https://doi.org/10.1016/j.neuron.2019.01.035

Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. / Back, Susanne; Necarsulmer, Julie; Whitaker, Leslie R.; Coke, Lamarque M.; Koivula, Pyry; Heathward, Emily J.; Fortuno, Lowella; Zhang, Yajun; Yeh, C. Grace; Baldwin, Heather A.; Spencer, Morgan D.; Mejias-Aponte, Carlos A.; Pickel, James; Hoffman, Alexander F.; Spivak, Charles E.; Lupica, Carl R.; Underhill, Suzanne M.; Amara, Susan G.; Domanskyi, Andrii; Anttila, Jenni E.; Airavaara, Mikko; Hope, Bruce T.; Hamra, F. Kent; Richie, Christopher T.; Harvey, Brandon K.

In: Neuron, Vol. 102, No. 1, 03.04.2019, p. 105-+.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats

AU - Back, Susanne

AU - Necarsulmer, Julie

AU - Whitaker, Leslie R.

AU - Coke, Lamarque M.

AU - Koivula, Pyry

AU - Heathward, Emily J.

AU - Fortuno, Lowella

AU - Zhang, Yajun

AU - Yeh, C. Grace

AU - Baldwin, Heather A.

AU - Spencer, Morgan D.

AU - Mejias-Aponte, Carlos A.

AU - Pickel, James

AU - Hoffman, Alexander F.

AU - Spivak, Charles E.

AU - Lupica, Carl R.

AU - Underhill, Suzanne M.

AU - Amara, Susan G.

AU - Domanskyi, Andrii

AU - Anttila, Jenni E.

AU - Airavaara, Mikko

AU - Hope, Bruce T.

AU - Hamra, F. Kent

AU - Richie, Christopher T.

AU - Harvey, Brandon K.

PY - 2019/4/3

Y1 - 2019/4/3

KW - HOMOLOGY-DIRECTED REPAIR

KW - ONE-STEP GENERATION

KW - NEUROTROPHIC FACTOR

KW - DOPAMINE RELEASE

KW - MICE

KW - RNA

KW - CAS9

KW - CRISPR/CAS9

KW - EXPRESSION

KW - MODELS

KW - 3112 Neurosciences

U2 - 10.1016/j.neuron.2019.01.035

DO - 10.1016/j.neuron.2019.01.035

M3 - Article

VL - 102

SP - 105-+

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 1

ER -

Back S, Necarsulmer J, Whitaker LR, Coke LM, Koivula P, Heathward EJ et al. Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron. 2019 Apr 3;102(1):105-+. https://doi.org/10.1016/j.neuron.2019.01.035