Neuronal regulation of immune responses in the central nervous system

Li Tian, Heikki Rauvala, Carl G Gahmberg

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    The central nervous system (CNS) has traditionally been considered to be immunologically privileged, but over the years there has been a re-evaluation of this dogma. To date, studies have tended to focus on the immune functions of glial cells, whereas the roles of neurons have been regarded as passive and their immune-regulatory properties have been less examined. However, recent findings indicate that CNS neurons actively participate in immune regulation by controlling their glial cell counterparts and infiltrated T cells. Here, we describe the immune-regulatory roles of CNS neurons by both contact-dependent and contact-independent mechanisms. In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity.
    Original languageEnglish
    JournalTrends in Immunology
    Volume30
    Issue number2
    Pages (from-to)91-99
    Number of pages9
    ISSN1471-4906
    DOIs
    Publication statusPublished - 2009
    MoE publication typeA1 Journal article-refereed

    Fields of Science

    • CELL-ADHESION MOLECULES
    • NECROSIS-FACTOR-ALPHA
    • NEURODEGENERATIVE DISEASES
    • T-CELLS
    • MULTIPLE-SCLEROSIS
    • MICROGLIAL ACTIVATION
    • LEUKOCYTE INTEGRIN
    • APOPTOTIC NEURONS
    • CNS INFLAMMATION
    • DENDRITIC CELLS
    • 118 Biological sciences

    Cite this

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    title = "Neuronal regulation of immune responses in the central nervous system",
    abstract = "The central nervous system (CNS) has traditionally been considered to be immunologically privileged, but over the years there has been a re-evaluation of this dogma. To date, studies have tended to focus on the immune functions of glial cells, whereas the roles of neurons have been regarded as passive and their immune-regulatory properties have been less examined. However, recent findings indicate that CNS neurons actively participate in immune regulation by controlling their glial cell counterparts and infiltrated T cells. Here, we describe the immune-regulatory roles of CNS neurons by both contact-dependent and contact-independent mechanisms. In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity.",
    keywords = "CELL-ADHESION MOLECULES, NECROSIS-FACTOR-ALPHA, NEURODEGENERATIVE DISEASES, T-CELLS, MULTIPLE-SCLEROSIS, MICROGLIAL ACTIVATION, LEUKOCYTE INTEGRIN, APOPTOTIC NEURONS, CNS INFLAMMATION, DENDRITIC CELLS, 118 Biological sciences",
    author = "Li Tian and Heikki Rauvala and Gahmberg, {Carl G}",
    year = "2009",
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    language = "English",
    volume = "30",
    pages = "91--99",
    journal = "Trends in Immunology",
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    Neuronal regulation of immune responses in the central nervous system. / Tian, Li; Rauvala, Heikki; Gahmberg, Carl G.

    In: Trends in Immunology, Vol. 30, No. 2, 2009, p. 91-99.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Neuronal regulation of immune responses in the central nervous system

    AU - Tian, Li

    AU - Rauvala, Heikki

    AU - Gahmberg, Carl G

    PY - 2009

    Y1 - 2009

    N2 - The central nervous system (CNS) has traditionally been considered to be immunologically privileged, but over the years there has been a re-evaluation of this dogma. To date, studies have tended to focus on the immune functions of glial cells, whereas the roles of neurons have been regarded as passive and their immune-regulatory properties have been less examined. However, recent findings indicate that CNS neurons actively participate in immune regulation by controlling their glial cell counterparts and infiltrated T cells. Here, we describe the immune-regulatory roles of CNS neurons by both contact-dependent and contact-independent mechanisms. In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity.

    AB - The central nervous system (CNS) has traditionally been considered to be immunologically privileged, but over the years there has been a re-evaluation of this dogma. To date, studies have tended to focus on the immune functions of glial cells, whereas the roles of neurons have been regarded as passive and their immune-regulatory properties have been less examined. However, recent findings indicate that CNS neurons actively participate in immune regulation by controlling their glial cell counterparts and infiltrated T cells. Here, we describe the immune-regulatory roles of CNS neurons by both contact-dependent and contact-independent mechanisms. In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity.

    KW - CELL-ADHESION MOLECULES

    KW - NECROSIS-FACTOR-ALPHA

    KW - NEURODEGENERATIVE DISEASES

    KW - T-CELLS

    KW - MULTIPLE-SCLEROSIS

    KW - MICROGLIAL ACTIVATION

    KW - LEUKOCYTE INTEGRIN

    KW - APOPTOTIC NEURONS

    KW - CNS INFLAMMATION

    KW - DENDRITIC CELLS

    KW - 118 Biological sciences

    U2 - 10.1016/j.it.2008.11.002

    DO - 10.1016/j.it.2008.11.002

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