New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

Matthew L. Arwood; Yao Liu; Shannon K. Harkins; David M. Weinstock; Lei Yang; Kristen E. Stevenson; Olivia D. Plana; Jingyun Dong; Haley Cirka; Kristen L. Jones; Anniina T. Virtanen; Dikshat G. Gupta; Amanda Ceas; Brian Lawney; Akinori Yoda; Catharine Leahy; Mingfeng Hao; Zhixiang He; Hwan Geun Choi; Yaning Wang; Olli Silvennoinen; Stevan R. Hubbard; Tinghu Zhang; Nathanael S. Gray; Loretta S. Li

doi:10.1016/j.chembiol.2023.05.007

New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

Matthew L. Arwood, Yao Liu, Shannon K. Harkins, David M. Weinstock, Lei Yang, Kristen E. Stevenson, Olivia D. Plana, Jingyun Dong, Haley Cirka, Kristen L. Jones, Anniina T. Virtanen, Dikshat G. Gupta, Amanda Ceas, Brian Lawney, Akinori Yoda, Catharine Leahy, Mingfeng Hao, Zhixiang He, Hwan Geun Choi, Yaning WangOlli Silvennoinen, Stevan R. Hubbard, Tinghu Zhang, Nathanael S. Gray, Loretta S. Li

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Cell chemical biology
Volume	30
Issue number	6
Pages (from-to)	618-+
Number of pages	27
ISSN	1879-1301
DOIs	https://doi.org/10.1016/j.chembiol.2023.05.007
Publication status	Published - 15 Jun 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

Ruxolitinib
Sensitivity
Persistence
Activation
Receptor
Binding
Chz868
Crlf2
1182 Biochemistry, cell and molecular biology

Access to Document

10.1016/j.chembiol.2023.05.007

Cite this

Arwood, M. L., Liu, Y., Harkins, S. K., Weinstock, D. M., Yang, L., Stevenson, K. E., Plana, O. D., Dong, J., Cirka, H., Jones, K. L., Virtanen, A. T., Gupta, D. G., Ceas, A., Lawney, B., Yoda, A., Leahy, C., Hao, M., He, Z., Choi, H. G., ... Li, L. S. (2023). New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. Cell chemical biology, 30(6), 618-+. https://doi.org/10.1016/j.chembiol.2023.05.007

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title = "New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation",

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author = "Arwood, {Matthew L.} and Yao Liu and Harkins, {Shannon K.} and Weinstock, {David M.} and Lei Yang and Stevenson, {Kristen E.} and Plana, {Olivia D.} and Jingyun Dong and Haley Cirka and Jones, {Kristen L.} and Virtanen, {Anniina T.} and Gupta, {Dikshat G.} and Amanda Ceas and Brian Lawney and Akinori Yoda and Catharine Leahy and Mingfeng Hao and Zhixiang He and Choi, {Hwan Geun} and Yaning Wang and Olli Silvennoinen and Hubbard, {Stevan R.} and Tinghu Zhang and Gray, {Nathanael S.} and Li, {Loretta S.}",

year = "2023",

month = jun,

day = "15",

doi = "10.1016/j.chembiol.2023.05.007",

language = "English",

volume = "30",

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journal = "Cell chemical biology",

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Arwood, ML, Liu, Y, Harkins, SK, Weinstock, DM, Yang, L, Stevenson, KE, Plana, OD, Dong, J, Cirka, H, Jones, KL, Virtanen, AT, Gupta, DG, Ceas, A, Lawney, B, Yoda, A, Leahy, C, Hao, M, He, Z, Choi, HG, Wang, Y, Silvennoinen, O, Hubbard, SR, Zhang, T, Gray, NS & Li, LS 2023, 'New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation', Cell chemical biology, vol. 30, no. 6, pp. 618-+. https://doi.org/10.1016/j.chembiol.2023.05.007

TY - JOUR

T1 - New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

AU - Arwood, Matthew L.

AU - Liu, Yao

AU - Harkins, Shannon K.

AU - Weinstock, David M.

AU - Yang, Lei

AU - Stevenson, Kristen E.

AU - Plana, Olivia D.

AU - Dong, Jingyun

AU - Cirka, Haley

AU - Jones, Kristen L.

AU - Virtanen, Anniina T.

AU - Gupta, Dikshat G.

AU - Ceas, Amanda

AU - Lawney, Brian

AU - Yoda, Akinori

AU - Leahy, Catharine

AU - Hao, Mingfeng

AU - He, Zhixiang

AU - Choi, Hwan Geun

AU - Wang, Yaning

AU - Silvennoinen, Olli

AU - Hubbard, Stevan R.

AU - Zhang, Tinghu

AU - Gray, Nathanael S.

AU - Li, Loretta S.

PY - 2023/6/15

Y1 - 2023/6/15

KW - Ruxolitinib

KW - Sensitivity

KW - Persistence

KW - Activation

KW - Receptor

KW - Binding

KW - Chz868

KW - Crlf2

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1016/j.chembiol.2023.05.007

DO - 10.1016/j.chembiol.2023.05.007

M3 - Article

C2 - 37290440

SN - 1879-1301

VL - 30

SP - 618-+

JO - Cell chemical biology

JF - Cell chemical biology

IS - 6

ER -