NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes

Minna Oksanen, Ida Hyötyläinen, Kalevi Trontti, Taisia Rolova, Sara Wojciechowski, Marja Koskuvi, Matti Viitanen, Anna-Liisa Levonen, Iiris Hovatta, Laurent Roybon, Sarka Lehtonen, Katja M. Kanninen, Riikka H. Hämäläinen, Jari Koistinaho

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalGlia
Volume68
Issue number3
Pages (from-to)589-599
Number of pages11
ISSN0894-1491
DOIs
Publication statusPublished - Mar 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Alzheimer's disease
  • astrocytes
  • inflammation
  • NRF2
  • oxidative stress
  • REMITTING MULTIPLE-SCLEROSIS
  • RELEASE DIMETHYL FUMARATE
  • OXIDATIVE STRESS
  • INTEGRATED ANALYSIS
  • MOUSE MODEL
  • GLUTATHIONE
  • NEURONS
  • NEUROINFLAMMATION
  • REGULATORS
  • 3112 Neurosciences
  • 3124 Neurology and psychiatry
  • 515 Psychology

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