Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalExperimental Brain Research
Volume235
Issue number7
Pages (from-to)2189-2202
Number of pages14
ISSN0014-4819
DOIs
Publication statusPublished - Jul 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Ubiquitin-proteasome system
  • Proteasome inhibition
  • Neuroinflammation
  • Neurodegeneration
  • Preclinical models
  • Alpha-synuclein
  • MULTIPLE SYSTEM ATROPHY
  • ALPHA-SYNUCLEIN
  • SUBSTANTIA-NIGRA
  • IN-VIVO
  • LEWY BODIES
  • FILAMENTOUS INCLUSIONS
  • MICROGLIAL ACTIVATION
  • TYROSINE-HYDROXYLASE
  • BASAL GANGLIA
  • UP-REGULATION
  • 3112 Neurosciences

Cite this

@article{11ba2b8d11bb43b482874d9fe48dd32a,
title = "Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse",
keywords = "Ubiquitin-proteasome system, Proteasome inhibition, Neuroinflammation, Neurodegeneration, Preclinical models, Alpha-synuclein, MULTIPLE SYSTEM ATROPHY, ALPHA-SYNUCLEIN, SUBSTANTIA-NIGRA, IN-VIVO, LEWY BODIES, FILAMENTOUS INCLUSIONS, MICROGLIAL ACTIVATION, TYROSINE-HYDROXYLASE, BASAL GANGLIA, UP-REGULATION, 3112 Neurosciences",
author = "Savolainen, {Mari H.} and Katrina Albert and Mikko Airavaara and Myoh{\"a}nen, {Timo T.}",
year = "2017",
month = "7",
doi = "10.1007/s00221-017-4962-z",
language = "English",
volume = "235",
pages = "2189--2202",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer",
number = "7",

}

TY - JOUR

T1 - Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse

AU - Savolainen, Mari H.

AU - Albert, Katrina

AU - Airavaara, Mikko

AU - Myohänen, Timo T.

PY - 2017/7

Y1 - 2017/7

KW - Ubiquitin-proteasome system

KW - Proteasome inhibition

KW - Neuroinflammation

KW - Neurodegeneration

KW - Preclinical models

KW - Alpha-synuclein

KW - MULTIPLE SYSTEM ATROPHY

KW - ALPHA-SYNUCLEIN

KW - SUBSTANTIA-NIGRA

KW - IN-VIVO

KW - LEWY BODIES

KW - FILAMENTOUS INCLUSIONS

KW - MICROGLIAL ACTIVATION

KW - TYROSINE-HYDROXYLASE

KW - BASAL GANGLIA

KW - UP-REGULATION

KW - 3112 Neurosciences

U2 - 10.1007/s00221-017-4962-z

DO - 10.1007/s00221-017-4962-z

M3 - Article

VL - 235

SP - 2189

EP - 2202

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

IS - 7

ER -