Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease

Tommi P. Kilpelainen; Henri T. Patsi; Reinis Svarcbahs; Ulrika H. Julku; Tony S. Eteläinen; Hengjing Cui; Samuli Auno; Nina Sipari; Susanna Norrbacka; Teppo O. Leino; Maria Jäntti; Timo T. Myöhänen; Erik A. A. Wallen

doi:10.1021/acs.jmedchem.3c00235

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease

Tommi P. Kilpelainen, Henri T. Patsi, Reinis Svarcbahs, Ulrika H. Julku, Tony S. Eteläinen, Hengjing Cui, Samuli Auno, Nina Sipari, Susanna Norrbacka, Teppo O. Leino, Maria Jäntti, Timo T. Myöhänen, Erik A. A. Wallen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Journal of Medicinal Chemistry
Volume	66
Issue number	11
Pages (from-to)	7475-7496
Number of pages	22
ISSN	0022-2623
DOIs	https://doi.org/10.1021/acs.jmedchem.3c00235
Publication status	Published - 29 May 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

Endopeptidase inhibitor
Efficient synthesis
Overexpression
Autophagy
Kyp-2047
Drug
Pharmacokinetics
Phosphorylation
Aggregation
Activation
317 Pharmacy

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10.1021/acs.jmedchem.3c00235Licence: CC BY

acs.jmedchem.3c00235Final published version, 7.84 MBLicence: CC BY

Viikki Metabolomics Unit (LS-RIA/ Metabo-HiLIFE)
Sipari, N. (Manager)
Faculty of Biological and Environmental Sciences
Facility/equipment: Core Facility

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Kilpelainen, T. P., Patsi, H. T., Svarcbahs, R., Julku, U. H., Eteläinen, T. S., Cui, H., Auno, S., Sipari, N., Norrbacka, S., Leino, T. O., Jäntti, M., Myöhänen, T. T., & Wallen, E. A. A. (2023). Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease. Journal of Medicinal Chemistry, 66(11), 7475-7496. https://doi.org/10.1021/acs.jmedchem.3c00235

@article{16a1b13f44d54dbbb1f4a84fa0485c6f,

title = "Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease",

keywords = "Endopeptidase inhibitor, Efficient synthesis, Overexpression, Autophagy, Kyp-2047, Drug, Pharmacokinetics, Phosphorylation, Aggregation, Activation, 317 Pharmacy",

author = "Kilpelainen, {Tommi P.} and Patsi, {Henri T.} and Reinis Svarcbahs and Julku, {Ulrika H.} and Etel{\"a}inen, {Tony S.} and Hengjing Cui and Samuli Auno and Nina Sipari and Susanna Norrbacka and Leino, {Teppo O.} and Maria J{\"a}ntti and My{\"o}h{\"a}nen, {Timo T.} and Wallen, {Erik A. A.}",

year = "2023",

month = may,

day = "29",

doi = "10.1021/acs.jmedchem.3c00235",

language = "English",

volume = "66",

pages = "7475--7496",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "11",

}

Kilpelainen, TP , Patsi, HT , Svarcbahs, R, Julku, UH, Eteläinen, TS, Cui, H, Auno, S, Sipari, N, Norrbacka, S, Leino, TO, Jäntti, M, Myöhänen, TT & Wallen, EAA 2023, 'Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease', Journal of Medicinal Chemistry, vol. 66, no. 11, pp. 7475-7496. https://doi.org/10.1021/acs.jmedchem.3c00235

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease. / Kilpelainen, Tommi P.; Patsi, Henri T.; Svarcbahs, Reinis et al.
In: Journal of Medicinal Chemistry, Vol. 66, No. 11, 29.05.2023, p. 7475-7496.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease

AU - Kilpelainen, Tommi P.

AU - Patsi, Henri T.

AU - Svarcbahs, Reinis

AU - Julku, Ulrika H.

AU - Eteläinen, Tony S.

AU - Cui, Hengjing

AU - Auno, Samuli

AU - Sipari, Nina

AU - Norrbacka, Susanna

AU - Leino, Teppo O.

AU - Jäntti, Maria

AU - Myöhänen, Timo T.

AU - Wallen, Erik A. A.

PY - 2023/5/29

Y1 - 2023/5/29

KW - Endopeptidase inhibitor

KW - Efficient synthesis

KW - Overexpression

KW - Autophagy

KW - Kyp-2047

KW - Drug

KW - Pharmacokinetics

KW - Phosphorylation

KW - Aggregation

KW - Activation

KW - 317 Pharmacy

U2 - 10.1021/acs.jmedchem.3c00235

DO - 10.1021/acs.jmedchem.3c00235

M3 - Article

C2 - 37248563

SN - 0022-2623

VL - 66

SP - 7475

EP - 7496

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 11

ER -

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease

Fields of Science

Access to Document

Equipment

Viikki Metabolomics Unit (LS-RIA/ Metabo-HiLIFE)

Cite this