Nonstop mRNAs generate a ground state of mitochondrial gene expression noise

Kah Ying Ng; Guleycan Lutfullahoglu Bal; Uwe Richter; Omid Safronov; Lars Paulin; Cory D. Dunn; Ville O. Paavilainen; Julie Richer; William G. Newman; Robert W. Taylor; Brendan J. Battersby

doi:10.1126/sciadv.abq5234

Nonstop mRNAs generate a ground state of mitochondrial gene expression noise

Kah Ying Ng, Guleycan Lutfullahoglu Bal, Uwe Richter, Omid Safronov, Lars Paulin, Cory D. Dunn, Ville O. Paavilainen, Julie Richer, William G. Newman, Robert W. Taylor, Brendan J. Battersby

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	eabq5234
Journal	Science Advances
Volume	8
Issue number	46
Number of pages	16
ISSN	2375-2548
DOIs	https://doi.org/10.1126/sciadv.abq5234
Publication status	Published - 18 Nov 2022
MoE publication type	A1 Journal article-refereed

Bibliographical note

Funding Information:
This work was supported by the Academy of Finland (307431 and 314706 to B.J.B.), the Sigrid Juselius Foundation Senior Investigator Award to B.J.B., and United Mitochondrial Disease Foundation (PI-16-0598 to B.J.B.) and donations from the Hereditary Neuropathy Foundation, Lindsey Flynt, and Medtronic to B.J.B.; the Orion Research Foundation and the Finnish Cultural Foundation to K.Y.N.; the Academy of Finland (321961 to U.R.); the Sigrid Juselius Foundation, the Academy of Finland (331556), and the Jane and Aatos Erkko Foundation to C.D.D.; Action Medical Research (GN2494 to W.G.N.) and the Manchester NIHR Biomedical Research Centre (IS-BRC-1215-20007 to W.G.N.); the Wellcome Centre for Mitochondrial Research (203105/Z/16/Z to R.W.T.), the Mitochondrial Disease Patient Cohort (UK) (G0800674 to R.W.T.), the Medical Research Council International Centre for Genomic Medicine in Neuromuscular Disease (MR/S005021/1 to R.W.T.), the Lily Foundation, the UK NIHR Biomedical Research Centre for Ageing and Age-related disease award to the Newcastle upon Tyne Foundation Hospitals NHS Trust, the Pathological Society, and the UK NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children to R.W.T.; Medical Research Council (MR/W019027/1 to W.G.N. and R.W.T.); the Academy of Finland (338836 and 314672 to V.O.P.); and the Sigrid Juselius Foundation and the Jane and Aatos Erkko Foundation.

Publisher Copyright:
Copyright © 2022 The Authors, some rights reserved;

Fields of Science

1184 Genetics, developmental biology, physiology

Access to Document

10.1126/sciadv.abq5234Licence: CC BY

sciadv.abq5234Final published version, 1.56 MBLicence: CC BY

Cite this

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title = "Nonstop mRNAs generate a ground state of mitochondrial gene expression noise",

keywords = "1184 Genetics, developmental biology, physiology",

author = "Ng, {Kah Ying} and Bal, {Guleycan Lutfullahoglu} and Uwe Richter and Omid Safronov and Lars Paulin and Dunn, {Cory D.} and Paavilainen, {Ville O.} and Julie Richer and Newman, {William G.} and Taylor, {Robert W.} and Battersby, {Brendan J.}",

note = "Funding Information: This work was supported by the Academy of Finland (307431 and 314706 to B.J.B.), the Sigrid Juselius Foundation Senior Investigator Award to B.J.B., and United Mitochondrial Disease Foundation (PI-16-0598 to B.J.B.) and donations from the Hereditary Neuropathy Foundation, Lindsey Flynt, and Medtronic to B.J.B.; the Orion Research Foundation and the Finnish Cultural Foundation to K.Y.N.; the Academy of Finland (321961 to U.R.); the Sigrid Juselius Foundation, the Academy of Finland (331556), and the Jane and Aatos Erkko Foundation to C.D.D.; Action Medical Research (GN2494 to W.G.N.) and the Manchester NIHR Biomedical Research Centre (IS-BRC-1215-20007 to W.G.N.); the Wellcome Centre for Mitochondrial Research (203105/Z/16/Z to R.W.T.), the Mitochondrial Disease Patient Cohort (UK) (G0800674 to R.W.T.), the Medical Research Council International Centre for Genomic Medicine in Neuromuscular Disease (MR/S005021/1 to R.W.T.), the Lily Foundation, the UK NIHR Biomedical Research Centre for Ageing and Age-related disease award to the Newcastle upon Tyne Foundation Hospitals NHS Trust, the Pathological Society, and the UK NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children to R.W.T.; Medical Research Council (MR/W019027/1 to W.G.N. and R.W.T.); the Academy of Finland (338836 and 314672 to V.O.P.); and the Sigrid Juselius Foundation and the Jane and Aatos Erkko Foundation. Publisher Copyright: Copyright {\textcopyright} 2022 The Authors, some rights reserved;",

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month = nov,

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doi = "10.1126/sciadv.abq5234",

language = "English",

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T1 - Nonstop mRNAs generate a ground state of mitochondrial gene expression noise

AU - Ng, Kah Ying

AU - Bal, Guleycan Lutfullahoglu

AU - Richter, Uwe

AU - Safronov, Omid

AU - Paulin, Lars

AU - Dunn, Cory D.

AU - Paavilainen, Ville O.

AU - Richer, Julie

AU - Newman, William G.

AU - Taylor, Robert W.

AU - Battersby, Brendan J.

N1 - Funding Information: This work was supported by the Academy of Finland (307431 and 314706 to B.J.B.), the Sigrid Juselius Foundation Senior Investigator Award to B.J.B., and United Mitochondrial Disease Foundation (PI-16-0598 to B.J.B.) and donations from the Hereditary Neuropathy Foundation, Lindsey Flynt, and Medtronic to B.J.B.; the Orion Research Foundation and the Finnish Cultural Foundation to K.Y.N.; the Academy of Finland (321961 to U.R.); the Sigrid Juselius Foundation, the Academy of Finland (331556), and the Jane and Aatos Erkko Foundation to C.D.D.; Action Medical Research (GN2494 to W.G.N.) and the Manchester NIHR Biomedical Research Centre (IS-BRC-1215-20007 to W.G.N.); the Wellcome Centre for Mitochondrial Research (203105/Z/16/Z to R.W.T.), the Mitochondrial Disease Patient Cohort (UK) (G0800674 to R.W.T.), the Medical Research Council International Centre for Genomic Medicine in Neuromuscular Disease (MR/S005021/1 to R.W.T.), the Lily Foundation, the UK NIHR Biomedical Research Centre for Ageing and Age-related disease award to the Newcastle upon Tyne Foundation Hospitals NHS Trust, the Pathological Society, and the UK NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children to R.W.T.; Medical Research Council (MR/W019027/1 to W.G.N. and R.W.T.); the Academy of Finland (338836 and 314672 to V.O.P.); and the Sigrid Juselius Foundation and the Jane and Aatos Erkko Foundation. Publisher Copyright: Copyright © 2022 The Authors, some rights reserved;

PY - 2022/11/18

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