Normal extinction and reinstatement of morphine-induced conditioned place preference in the GluA1-KO mouse line

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Extinction and reinstatement of morphine-induced conditioned place preference were studied in glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-receptor GluA1 subunit-deficient mice (global GluA1-KO mice). In line with previous findings, both acquisition and expression of conditioned place preference to morphine (20 mg/kg, subcutaneously) were fully functional in GluA1 KO mice compared with wild-type littermate controls (GluA1-WT), thus enabling the study of extinction. With a 10-session extinction paradigm, the GluA1 KO mice showed complete extinction similar to that of the GluA1-WT mice. Morphine-induced reinstatement (10 mg/kg, subcutaneously) was detected in both mouse lines. GluA1 KO mice moved more during all the phases of the experiment, including the place conditioning trials, extinction sessions, and place preference tests. The results suggest that the GluA1 subunit may be dispensable or prone to compensation at the neural circuitries delineating extinction and reinstatement. The GluA1 KO mice show altered long-term between-session habituation, which extends longer than previously anticipated.
Original languageEnglish
JournalBehavioural Pharmacology
Volume30
Issue number5
Pages (from-to)405-411
Number of pages7
ISSN0955-8810
DOIs
Publication statusPublished - Aug 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 317 Pharmacy
  • alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
  • conditioned place preference
  • extinction
  • glutamate
  • morphine
  • rat
  • reinstatement
  • COCAINE-INDUCED REINSTATEMENT
  • NUCLEUS-ACCUMBENS CORE
  • LONG-TERM POTENTIATION
  • AMPA RECEPTORS
  • SYNAPTIC PLASTICITY
  • GLUTAMATE RECEPTORS
  • DOPAMINE NEURONS
  • GLUR1 SUBUNIT
  • RELAPSE
  • SEEKING

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