Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Nalle Pentinmikko; Sharif Iqbal; Miyeko Mana; Simon Andersson; Armand B. Cognetta; Radu M. Suciu; Jatin Roper; Kalle Luopajärvi; Eino Markelin; Swetha Gopalakrishnan; Olli-Pekka Smolander; Santiago Naranjo; Tuure Saarinen; Anne Juuti; Kirsi Pietiläinen; Petri Auvinen; Ari Ristimäki; Nitin Gupta; Tuomas Tammela; Tyler Jacks; David M. Sabatini; Benjamin F. Cravatt; Omer H. Yilmaz; Pekka Katajisto

doi:10.1038/s41586-019-1383-0

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Nalle Pentinmikko, Sharif Iqbal, Miyeko Mana, Simon Andersson, Armand B. Cognetta, Radu M. Suciu, Jatin Roper, Kalle Luopajärvi, Eino Markelin, Swetha Gopalakrishnan, Olli-Pekka Smolander, Santiago Naranjo, Tuure Saarinen, Anne Juuti, Kirsi Pietiläinen, Petri Auvinen, Ari Ristimäki, Nitin Gupta, Tuomas Tammela, Tyler JacksDavid M. Sabatini, Benjamin F. Cravatt, Omer H. Yilmaz, Pekka Katajisto

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature
Volume	571
Issue number	7765
Pages (from-to)	398-+
Number of pages	21
ISSN	0028-0836
DOIs	https://doi.org/10.1038/s41586-019-1383-0
Publication status	Published - 18 Jul 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

STEM-CELLS
COLORECTAL-CANCER
LIFE-SPAN
ACID
IDENTIFICATION
ACTIVATION
KNOCKOUT
COLON
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology

Access to Document

10.1038/s41586-019-1383-0

s41586-019-1383-0Final published version, 10.3 MB

Cite this

Pentinmikko, N., Iqbal, S., Mana, M., Andersson, S., Cognetta, A. B., Suciu, R. M., Roper, J., Luopajärvi, K., Markelin, E., Gopalakrishnan, S., Smolander, O-P., Naranjo, S., Saarinen, T., Juuti, A., Pietiläinen, K., Auvinen, P., Ristimäki, A., Gupta, N., Tammela, T., ... Katajisto, P. (2019). Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. Nature, 571(7765), 398-+. https://doi.org/10.1038/s41586-019-1383-0

@article{e1104302b1a04e4580816fe665c92659,

title = "Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium",

keywords = "STEM-CELLS, COLORECTAL-CANCER, LIFE-SPAN, ACID, IDENTIFICATION, ACTIVATION, KNOCKOUT, COLON, 3111 Biomedicine, 3121 General medicine, internal medicine and other clinical medicine, 3126 Surgery, anesthesiology, intensive care, radiology",

author = "Nalle Pentinmikko and Sharif Iqbal and Miyeko Mana and Simon Andersson and Cognetta, {Armand B.} and Suciu, {Radu M.} and Jatin Roper and Kalle Luopaj{\"a}rvi and Eino Markelin and Swetha Gopalakrishnan and Olli-Pekka Smolander and Santiago Naranjo and Tuure Saarinen and Anne Juuti and Kirsi Pietil{\"a}inen and Petri Auvinen and Ari Ristim{\"a}ki and Nitin Gupta and Tuomas Tammela and Tyler Jacks and Sabatini, {David M.} and Cravatt, {Benjamin F.} and Yilmaz, {Omer H.} and Pekka Katajisto",

year = "2019",

month = jul,

day = "18",

doi = "10.1038/s41586-019-1383-0",

language = "English",

volume = "571",

pages = "398--+",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "7765",

}

Pentinmikko, N , Iqbal, S, Mana, M, Andersson, S, Cognetta, AB, Suciu, RM, Roper, J, Luopajärvi, K, Markelin, E, Gopalakrishnan, S, Smolander, O-P, Naranjo, S, Saarinen, T , Juuti, A , Pietiläinen, K , Auvinen, P , Ristimäki, A, Gupta, N, Tammela, T, Jacks, T, Sabatini, DM, Cravatt, BF, Yilmaz, OH & Katajisto, P 2019, 'Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium', Nature, vol. 571, no. 7765, pp. 398-+. https://doi.org/10.1038/s41586-019-1383-0

TY - JOUR

T1 - Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

AU - Pentinmikko, Nalle

AU - Iqbal, Sharif

AU - Mana, Miyeko

AU - Andersson, Simon

AU - Cognetta, Armand B.

AU - Suciu, Radu M.

AU - Roper, Jatin

AU - Luopajärvi, Kalle

AU - Markelin, Eino

AU - Gopalakrishnan, Swetha

AU - Smolander, Olli-Pekka

AU - Naranjo, Santiago

AU - Saarinen, Tuure

AU - Juuti, Anne

AU - Pietiläinen, Kirsi

AU - Auvinen, Petri

AU - Ristimäki, Ari

AU - Gupta, Nitin

AU - Tammela, Tuomas

AU - Jacks, Tyler

AU - Sabatini, David M.

AU - Cravatt, Benjamin F.

AU - Yilmaz, Omer H.

AU - Katajisto, Pekka

PY - 2019/7/18

Y1 - 2019/7/18

KW - STEM-CELLS

KW - COLORECTAL-CANCER

KW - LIFE-SPAN

KW - ACID

KW - IDENTIFICATION

KW - ACTIVATION

KW - KNOCKOUT

KW - COLON

KW - 3111 Biomedicine

KW - 3121 General medicine, internal medicine and other clinical medicine

KW - 3126 Surgery, anesthesiology, intensive care, radiology

U2 - 10.1038/s41586-019-1383-0

DO - 10.1038/s41586-019-1383-0

M3 - Article

VL - 571

SP - 398-+

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7765

ER -