Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Min Ju Park, Hailian Shen, Jason M. Spaeth, Jaana H. Tolvanen, Courtney Failor, Jennifer F. Knudtson, Jessica McLaughlin, Sunil K. Halder, Qiwei Yang, Serdar E. Bulun, Ayman Al-Hendy, Robert S. Schenken, Lauri A. Aaltonen, Thomas G. Boyer

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Biological Chemistry
Volume293
Issue number13
Pages (from-to)4870-4882
Number of pages13
ISSN0021-9258
DOIs
Publication statusPublished - 30 Mar 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • UTERINE FIBROIDS
  • PROTEIN-KINASES
  • TRANSCRIPTIONAL REGULATION
  • TARGET GENES
  • COMPLEX
  • LEIOMYOMA
  • REVEALS
  • IDENTIFICATION
  • TUMORIGENESIS
  • GENOMICS
  • 3111 Biomedicine
  • 1182 Biochemistry, cell and molecular biology

Cite this

Park, M. J., Shen, H., Spaeth, J. M., Tolvanen, J. H., Failor, C., Knudtson, J. F., McLaughlin, J., Halder, S. K., Yang, Q., Bulun, S. E., Al-Hendy, A., Schenken, R. S., Aaltonen, L. A., & Boyer, T. G. (2018). Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19. Journal of Biological Chemistry, 293(13), 4870-4882. https://doi.org/10.1074/jbc.RA118.001725