Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Min Ju Park, Hailian Shen, Jason M. Spaeth, Jaana H. Tolvanen, Courtney Failor, Jennifer F. Knudtson, Jessica McLaughlin, Sunil K. Halder, Qiwei Yang, Serdar E. Bulun, Ayman Al-Hendy, Robert S. Schenken, Lauri A. Aaltonen, Thomas G. Boyer

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Biological Chemistry
Volume293
Issue number13
Pages (from-to)4870-4882
Number of pages13
ISSN0021-9258
DOIs
Publication statusPublished - 30 Mar 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • UTERINE FIBROIDS
  • PROTEIN-KINASES
  • TRANSCRIPTIONAL REGULATION
  • TARGET GENES
  • COMPLEX
  • LEIOMYOMA
  • REVEALS
  • IDENTIFICATION
  • TUMORIGENESIS
  • GENOMICS
  • 3111 Biomedicine
  • 1182 Biochemistry, cell and molecular biology

Cite this

Park, Min Ju ; Shen, Hailian ; Spaeth, Jason M. ; Tolvanen, Jaana H. ; Failor, Courtney ; Knudtson, Jennifer F. ; McLaughlin, Jessica ; Halder, Sunil K. ; Yang, Qiwei ; Bulun, Serdar E. ; Al-Hendy, Ayman ; Schenken, Robert S. ; Aaltonen, Lauri A. ; Boyer, Thomas G. / Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19. In: Journal of Biological Chemistry. 2018 ; Vol. 293, No. 13. pp. 4870-4882.
@article{fb39331578af4cfeaea18ba63e1e7002,
title = "Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19",
keywords = "UTERINE FIBROIDS, PROTEIN-KINASES, TRANSCRIPTIONAL REGULATION, TARGET GENES, COMPLEX, LEIOMYOMA, REVEALS, IDENTIFICATION, TUMORIGENESIS, GENOMICS, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology",
author = "Park, {Min Ju} and Hailian Shen and Spaeth, {Jason M.} and Tolvanen, {Jaana H.} and Courtney Failor and Knudtson, {Jennifer F.} and Jessica McLaughlin and Halder, {Sunil K.} and Qiwei Yang and Bulun, {Serdar E.} and Ayman Al-Hendy and Schenken, {Robert S.} and Aaltonen, {Lauri A.} and Boyer, {Thomas G.}",
year = "2018",
month = "3",
day = "30",
doi = "10.1074/jbc.RA118.001725",
language = "English",
volume = "293",
pages = "4870--4882",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology",
number = "13",

}

Park, MJ, Shen, H, Spaeth, JM, Tolvanen, JH, Failor, C, Knudtson, JF, McLaughlin, J, Halder, SK, Yang, Q, Bulun, SE, Al-Hendy, A, Schenken, RS, Aaltonen, LA & Boyer, TG 2018, 'Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19' Journal of Biological Chemistry, vol. 293, no. 13, pp. 4870-4882. https://doi.org/10.1074/jbc.RA118.001725

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19. / Park, Min Ju; Shen, Hailian; Spaeth, Jason M.; Tolvanen, Jaana H.; Failor, Courtney; Knudtson, Jennifer F.; McLaughlin, Jessica; Halder, Sunil K.; Yang, Qiwei; Bulun, Serdar E.; Al-Hendy, Ayman; Schenken, Robert S.; Aaltonen, Lauri A.; Boyer, Thomas G.

In: Journal of Biological Chemistry, Vol. 293, No. 13, 30.03.2018, p. 4870-4882.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

AU - Park, Min Ju

AU - Shen, Hailian

AU - Spaeth, Jason M.

AU - Tolvanen, Jaana H.

AU - Failor, Courtney

AU - Knudtson, Jennifer F.

AU - McLaughlin, Jessica

AU - Halder, Sunil K.

AU - Yang, Qiwei

AU - Bulun, Serdar E.

AU - Al-Hendy, Ayman

AU - Schenken, Robert S.

AU - Aaltonen, Lauri A.

AU - Boyer, Thomas G.

PY - 2018/3/30

Y1 - 2018/3/30

KW - UTERINE FIBROIDS

KW - PROTEIN-KINASES

KW - TRANSCRIPTIONAL REGULATION

KW - TARGET GENES

KW - COMPLEX

KW - LEIOMYOMA

KW - REVEALS

KW - IDENTIFICATION

KW - TUMORIGENESIS

KW - GENOMICS

KW - 3111 Biomedicine

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1074/jbc.RA118.001725

DO - 10.1074/jbc.RA118.001725

M3 - Article

VL - 293

SP - 4870

EP - 4882

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 13

ER -