One-Year Follow-up Study Detects Myocardial Changes with Cardiovascular Magnetic Resonance Tagging in Active Rheumatoid Arthritis

thritis

Lauri Lehmonen, Aino-Maija Vuorinen, Riitta Koivuniemi, Marjatta Leirisalo-Repo, Miia Maria Holmström, Sari Kivistö, Touko Kaasalainen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

RATIONALE AND OBJECTIVES: To evaluate the effects of 1 year of medical treatment on myocardial function in active rheumatoid arthritis (RA). MATERIALS AND METHODS: Thirty-nine female patients with RA without any known cardiovascular disease underwent a cardiovascular magnetic resonance (CMR) examination before and after 1 year of antirheumatic treatment. The population comprised untreated active early RA (ERA) and chronic RA patients, who were grouped accordingly. The CMR protocol included volumetric determinations, late gadolinium enhancement imaging, myocardial tagging, and native T1 mapping. DAS28-CRP disease activity scores were calculated before and after the treatment. RESULTS: Results are reported as median (quartile 1-quartile 3). Time to peak diastolic filling rate improved in ERA (495 [443-561] ms vs 441 [340-518] ms, P = .018). Peak diastolic mean mid short-axis circumferential strain rate of all six segments was improved (82 [74-91] %/s vs 91 [77-100] %/s, P = .05), particularly in the anterior segment (82 [63-98] %/s vs 86 [77-109] %/s, P = .013). DAS28-CRP decreased in ERA (3.8 [3.2-4.1] vs 1.6 [1.4-2.2], P < .001). In chronic RA, no statistically significant improvement was detected. CONCLUSIONS: Early treatment of active RA is important, as myocardial function detected with CMR tagging improved in ERA in parallel with decreasing inflammatory activity.
Original languageEnglish
JournalAcademic Radiology
Volume25
Issue number4
Pages (from-to)476-485
Number of pages10
ISSN1076-6332
DOIs
Publication statusPublished - Apr 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 114 Physical sciences
  • 3126 Surgery, anesthesiology, intensive care, radiology
  • Cardiovascular magnetic resonance imaging
  • tagging
  • strain
  • rheumatoid arthritis
  • HEART-FAILURE
  • ASYMPTOMATIC INDIVIDUALS
  • CIRCUMFERENTIAL STRAIN
  • DIASTOLIC DYSFUNCTION
  • INCREASED PREVALENCE
  • PROGNOSTIC VALUE
  • ATHEROSCLEROSIS
  • INVOLVEMENT
  • CMR
  • ECHOCARDIOGRAPHY

Cite this

@article{e8f780d9baae45d4b1dbe6c87ccccb33,
title = "One-Year Follow-up Study Detects Myocardial Changes with Cardiovascular Magnetic Resonance Tagging in Active Rheumatoid Arthritis: thritis",
abstract = "RATIONALE AND OBJECTIVES: To evaluate the effects of 1 year of medical treatment on myocardial function in active rheumatoid arthritis (RA). MATERIALS AND METHODS: Thirty-nine female patients with RA without any known cardiovascular disease underwent a cardiovascular magnetic resonance (CMR) examination before and after 1 year of antirheumatic treatment. The population comprised untreated active early RA (ERA) and chronic RA patients, who were grouped accordingly. The CMR protocol included volumetric determinations, late gadolinium enhancement imaging, myocardial tagging, and native T1 mapping. DAS28-CRP disease activity scores were calculated before and after the treatment. RESULTS: Results are reported as median (quartile 1-quartile 3). Time to peak diastolic filling rate improved in ERA (495 [443-561] ms vs 441 [340-518] ms, P = .018). Peak diastolic mean mid short-axis circumferential strain rate of all six segments was improved (82 [74-91] {\%}/s vs 91 [77-100] {\%}/s, P = .05), particularly in the anterior segment (82 [63-98] {\%}/s vs 86 [77-109] {\%}/s, P = .013). DAS28-CRP decreased in ERA (3.8 [3.2-4.1] vs 1.6 [1.4-2.2], P < .001). In chronic RA, no statistically significant improvement was detected. CONCLUSIONS: Early treatment of active RA is important, as myocardial function detected with CMR tagging improved in ERA in parallel with decreasing inflammatory activity.",
keywords = "114 Physical sciences, 3126 Surgery, anesthesiology, intensive care, radiology, Cardiovascular magnetic resonance imaging, tagging, strain, rheumatoid arthritis, HEART-FAILURE, ASYMPTOMATIC INDIVIDUALS, CIRCUMFERENTIAL STRAIN, DIASTOLIC DYSFUNCTION, INCREASED PREVALENCE, PROGNOSTIC VALUE, ATHEROSCLEROSIS, INVOLVEMENT, CMR, ECHOCARDIOGRAPHY",
author = "Lauri Lehmonen and Aino-Maija Vuorinen and Riitta Koivuniemi and Marjatta Leirisalo-Repo and Holmstr{\"o}m, {Miia Maria} and Sari Kivist{\"o} and Touko Kaasalainen",
year = "2018",
month = "4",
doi = "10.1016/j.acra.2017.10.017",
language = "English",
volume = "25",
pages = "476--485",
journal = "Academic Radiology",
issn = "1076-6332",
publisher = "Elsevier B. V.",
number = "4",

}

One-Year Follow-up Study Detects Myocardial Changes with Cardiovascular Magnetic Resonance Tagging in Active Rheumatoid Arthritis : thritis. / Lehmonen, Lauri; Vuorinen, Aino-Maija ; Koivuniemi, Riitta; Leirisalo-Repo, Marjatta; Holmström, Miia Maria; Kivistö, Sari; Kaasalainen, Touko.

In: Academic Radiology, Vol. 25, No. 4, 04.2018, p. 476-485.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - One-Year Follow-up Study Detects Myocardial Changes with Cardiovascular Magnetic Resonance Tagging in Active Rheumatoid Arthritis

T2 - thritis

AU - Lehmonen, Lauri

AU - Vuorinen, Aino-Maija

AU - Koivuniemi, Riitta

AU - Leirisalo-Repo, Marjatta

AU - Holmström, Miia Maria

AU - Kivistö, Sari

AU - Kaasalainen, Touko

PY - 2018/4

Y1 - 2018/4

N2 - RATIONALE AND OBJECTIVES: To evaluate the effects of 1 year of medical treatment on myocardial function in active rheumatoid arthritis (RA). MATERIALS AND METHODS: Thirty-nine female patients with RA without any known cardiovascular disease underwent a cardiovascular magnetic resonance (CMR) examination before and after 1 year of antirheumatic treatment. The population comprised untreated active early RA (ERA) and chronic RA patients, who were grouped accordingly. The CMR protocol included volumetric determinations, late gadolinium enhancement imaging, myocardial tagging, and native T1 mapping. DAS28-CRP disease activity scores were calculated before and after the treatment. RESULTS: Results are reported as median (quartile 1-quartile 3). Time to peak diastolic filling rate improved in ERA (495 [443-561] ms vs 441 [340-518] ms, P = .018). Peak diastolic mean mid short-axis circumferential strain rate of all six segments was improved (82 [74-91] %/s vs 91 [77-100] %/s, P = .05), particularly in the anterior segment (82 [63-98] %/s vs 86 [77-109] %/s, P = .013). DAS28-CRP decreased in ERA (3.8 [3.2-4.1] vs 1.6 [1.4-2.2], P < .001). In chronic RA, no statistically significant improvement was detected. CONCLUSIONS: Early treatment of active RA is important, as myocardial function detected with CMR tagging improved in ERA in parallel with decreasing inflammatory activity.

AB - RATIONALE AND OBJECTIVES: To evaluate the effects of 1 year of medical treatment on myocardial function in active rheumatoid arthritis (RA). MATERIALS AND METHODS: Thirty-nine female patients with RA without any known cardiovascular disease underwent a cardiovascular magnetic resonance (CMR) examination before and after 1 year of antirheumatic treatment. The population comprised untreated active early RA (ERA) and chronic RA patients, who were grouped accordingly. The CMR protocol included volumetric determinations, late gadolinium enhancement imaging, myocardial tagging, and native T1 mapping. DAS28-CRP disease activity scores were calculated before and after the treatment. RESULTS: Results are reported as median (quartile 1-quartile 3). Time to peak diastolic filling rate improved in ERA (495 [443-561] ms vs 441 [340-518] ms, P = .018). Peak diastolic mean mid short-axis circumferential strain rate of all six segments was improved (82 [74-91] %/s vs 91 [77-100] %/s, P = .05), particularly in the anterior segment (82 [63-98] %/s vs 86 [77-109] %/s, P = .013). DAS28-CRP decreased in ERA (3.8 [3.2-4.1] vs 1.6 [1.4-2.2], P < .001). In chronic RA, no statistically significant improvement was detected. CONCLUSIONS: Early treatment of active RA is important, as myocardial function detected with CMR tagging improved in ERA in parallel with decreasing inflammatory activity.

KW - 114 Physical sciences

KW - 3126 Surgery, anesthesiology, intensive care, radiology

KW - Cardiovascular magnetic resonance imaging

KW - tagging

KW - strain

KW - rheumatoid arthritis

KW - HEART-FAILURE

KW - ASYMPTOMATIC INDIVIDUALS

KW - CIRCUMFERENTIAL STRAIN

KW - DIASTOLIC DYSFUNCTION

KW - INCREASED PREVALENCE

KW - PROGNOSTIC VALUE

KW - ATHEROSCLEROSIS

KW - INVOLVEMENT

KW - CMR

KW - ECHOCARDIOGRAPHY

U2 - 10.1016/j.acra.2017.10.017

DO - 10.1016/j.acra.2017.10.017

M3 - Article

VL - 25

SP - 476

EP - 485

JO - Academic Radiology

JF - Academic Radiology

SN - 1076-6332

IS - 4

ER -