Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Kingsley Ekumi, Hana Paculova, Tina Lenasi, Vendula Pospichalova, Christian A. Boesken, Jana Rybarikova, Vitezslav Bryja, Matthias Geyer, Dalibor Blazek, Matjaz Barboric

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNucleic Acids Research
Volume43
Issue number5
Pages (from-to)2575-2589
Number of pages15
ISSN0305-1048
DOIs
Publication statusPublished - 11 Mar 2015
MoE publication typeA1 Journal article-refereed

Fields of Science

  • RNA-POLYMERASE-II
  • PRE-MESSENGER-RNA
  • MAINTAINS GENOMIC STABILITY
  • CYCLIN K/CDK12 COMPLEX
  • TRANSCRIPTION IN-VIVO
  • C-TERMINAL DOMAIN
  • HOMOLOGOUS RECOMBINATION
  • P-TEFB
  • KINASE
  • ELONGATION
  • 3111 Biomedicine
  • 3122 Cancers

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