Pharmaceutical compositions of levo-enantiomers of medetomidine derivatives and their use

Karl Åkerman, Christian C. Jansson, Jyrki (P) Kukkonen, Juha-Matti Savola, Siegfried Wurster, Victor Cockcroft

Research output: Patent


The levo-isomers of certain imidazole derivatives, particularly medetomidine, have been found to be inverse agonists of adrenergic &#x0b31-2 receptors and are therefore useful in the prevention or treatment of conditions associated with overexpression or hypersensitization of the adrenergic &#x0b31-2 receptors, such as obesity, a withdrawal symptom to an adrenergic &#x0b31-2 receptor agonist, a neurological disorder, multiple system atrophy, diabetes mellitus, benign prostatic hyperplasia, and drug-induced sensitization of adrenergic &#x0b31-2 receptors. The pharmaceutical composition is preferably transdermal.
Original languageEnglish
Publication Year30 Nov 1999
Publication statusPublished - 30 Nov 1999
MoE publication typeH1 Granted patent

Cite this