Pharmacogenomics of Hypertension: A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs

Timo P. Hiltunen; Kati M. Donner; Antti-Pekka Sarin; Janna Saarela; Samuli Ripatti; Arlene B. Chapman; John G. Gums; Yan Gong; Rhonda M. Cooper-DeHoff; Francesca Frau; Valeria Glorioso; Roberta Zaninello; Erika Salvi; Nicola Glorioso; Eric Boerwinkle; Stephen T. Turner; Julie A. Johnson; Kimmo K. Kontula

doi:10.1161/JAHA.114.001521

Pharmacogenomics of Hypertension: A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs

Timo P. Hiltunen, Kati M. Donner, Antti-Pekka Sarin, Janna Saarela, Samuli Ripatti, Arlene B. Chapman, John G. Gums, Yan Gong, Rhonda M. Cooper-DeHoff, Francesca Frau, Valeria Glorioso, Roberta Zaninello, Erika Salvi, Nicola Glorioso, Eric Boerwinkle, Stephen T. Turner, Julie A. Johnson, Kimmo K. Kontula

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	001521
Journal	Journal of the American Heart Association
Volume	4
Issue number	1
Number of pages	26
ISSN	2047-9980
DOIs	https://doi.org/10.1161/JAHA.114.001521
Publication status	Published - Jan 2015
MoE publication type	A1 Journal article-refereed

Fields of Science

antihypertensive drug
association study
drug response
genome-wide
hypertension
BLOOD-PRESSURE RESPONSE
TUBULE EPITHELIAL-CELLS
ASSOCIATION ANALYSIS
NEPHRIN EXPRESSION
RECEPTOR BLOCKER
PREDICTORS
HYDROCHLOROTHIAZIDE
METAANALYSIS
LOSARTAN
DISEASE
3121 Internal medicine

Access to Document

10.1161/JAHA.114.001521

Cite this

Hiltunen, T. P., Donner, K. M., Sarin, A-P., Saarela, J., Ripatti, S., Chapman, A. B., Gums, J. G., Gong, Y., Cooper-DeHoff, R. M., Frau, F., Glorioso, V., Zaninello, R., Salvi, E., Glorioso, N., Boerwinkle, E., Turner, S. T., Johnson, J. A., & Kontula, K. K. (2015). Pharmacogenomics of Hypertension: A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs. Journal of the American Heart Association, 4(1), [001521]. https://doi.org/10.1161/JAHA.114.001521

Hiltunen, Timo P. ; Donner, Kati M. ; Sarin, Antti-Pekka ; Saarela, Janna ; Ripatti, Samuli ; Chapman, Arlene B. ; Gums, John G. ; Gong, Yan ; Cooper-DeHoff, Rhonda M. ; Frau, Francesca ; Glorioso, Valeria ; Zaninello, Roberta ; Salvi, Erika ; Glorioso, Nicola ; Boerwinkle, Eric ; Turner, Stephen T. ; Johnson, Julie A. ; Kontula, Kimmo K. / Pharmacogenomics of Hypertension : A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs. In: Journal of the American Heart Association. 2015 ; Vol. 4, No. 1.

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title = "Pharmacogenomics of Hypertension: A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs",

keywords = "antihypertensive drug, association study, drug response, genome-wide, hypertension, BLOOD-PRESSURE RESPONSE, TUBULE EPITHELIAL-CELLS, ASSOCIATION ANALYSIS, NEPHRIN EXPRESSION, RECEPTOR BLOCKER, PREDICTORS, HYDROCHLOROTHIAZIDE, METAANALYSIS, LOSARTAN, DISEASE, 3121 Internal medicine",

author = "Hiltunen, {Timo P.} and Donner, {Kati M.} and Antti-Pekka Sarin and Janna Saarela and Samuli Ripatti and Chapman, {Arlene B.} and Gums, {John G.} and Yan Gong and Cooper-DeHoff, {Rhonda M.} and Francesca Frau and Valeria Glorioso and Roberta Zaninello and Erika Salvi and Nicola Glorioso and Eric Boerwinkle and Turner, {Stephen T.} and Johnson, {Julie A.} and Kontula, {Kimmo K.}",

year = "2015",

month = jan,

doi = "10.1161/JAHA.114.001521",

language = "English",

volume = "4",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "Wiley",

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Hiltunen, TP , Donner, KM, Sarin, A-P, Saarela, J , Ripatti, S, Chapman, AB, Gums, JG, Gong, Y, Cooper-DeHoff, RM, Frau, F, Glorioso, V, Zaninello, R, Salvi, E, Glorioso, N, Boerwinkle, E, Turner, ST, Johnson, JA & Kontula, KK 2015, 'Pharmacogenomics of Hypertension: A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs', Journal of the American Heart Association, vol. 4, no. 1, 001521. https://doi.org/10.1161/JAHA.114.001521

Pharmacogenomics of Hypertension : A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs. / Hiltunen, Timo P.; Donner, Kati M.; Sarin, Antti-Pekka; Saarela, Janna ; Ripatti, Samuli; Chapman, Arlene B.; Gums, John G.; Gong, Yan; Cooper-DeHoff, Rhonda M.; Frau, Francesca; Glorioso, Valeria; Zaninello, Roberta; Salvi, Erika; Glorioso, Nicola; Boerwinkle, Eric; Turner, Stephen T.; Johnson, Julie A.; Kontula, Kimmo K.

In: Journal of the American Heart Association, Vol. 4, No. 1, 001521, 01.2015.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Pharmacogenomics of Hypertension

T2 - A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs

AU - Hiltunen, Timo P.

AU - Donner, Kati M.

AU - Sarin, Antti-Pekka

AU - Saarela, Janna

AU - Ripatti, Samuli

AU - Chapman, Arlene B.

AU - Gums, John G.

AU - Gong, Yan

AU - Cooper-DeHoff, Rhonda M.

AU - Frau, Francesca

AU - Glorioso, Valeria

AU - Zaninello, Roberta

AU - Salvi, Erika

AU - Glorioso, Nicola

AU - Boerwinkle, Eric

AU - Turner, Stephen T.

AU - Johnson, Julie A.

AU - Kontula, Kimmo K.

PY - 2015/1

Y1 - 2015/1

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KW - association study

KW - drug response

KW - genome-wide

KW - hypertension

KW - BLOOD-PRESSURE RESPONSE

KW - TUBULE EPITHELIAL-CELLS

KW - ASSOCIATION ANALYSIS

KW - NEPHRIN EXPRESSION

KW - RECEPTOR BLOCKER

KW - PREDICTORS

KW - HYDROCHLOROTHIAZIDE

KW - METAANALYSIS

KW - LOSARTAN

KW - DISEASE

KW - 3121 Internal medicine

U2 - 10.1161/JAHA.114.001521

DO - 10.1161/JAHA.114.001521

M3 - Article

VL - 4

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

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M1 - 001521

ER -