Projects per year
Abstract
Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to administer drugs to the retina, but this approach is applicable only in selected cases (e.g. anti-VEGF antibodies and soluble receptors). There are two basic approaches that can be adopted to improve retinal drug delivery: prolonged and/or retina targeted delivery of intravitreal drugs and use of other routes of drug administration, such as periocular, suprachoroidal, sub-retinal, systemic, or topical. Properties of the administration route, drug and delivery system determine the efficacy and safety of these approaches. Pharmacokinetic and pharmacodynamic factors determine the required dosing rates and doses that are needed for drug action. In addition, tolerability factors limit the use of many materials in ocular drug delivery. This review article provides a critical discussion of retinal drug delivery, particularly from the pharmacokinetic point of view. This article does not include an extensive review of drug delivery technologies, because they have already been reviewed several times recently. Instead, we aim to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment. This review is based on the literature and unpublished data from the authors' laboratory.
Original language | English |
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Journal | Progress in Retinal and Eye Research |
Volume | 57 |
Pages (from-to) | 134-185 |
Number of pages | 52 |
ISSN | 1350-9462 |
DOIs | |
Publication status | Published - Mar 2017 |
MoE publication type | A2 Review article in a scientific journal |
Fields of Science
- 317 Pharmacy
- 3125 Otorhinolaryngology, ophthalmology
- Retina
- Vitreous
- Choroid
- Topical
- Intravitreal
- Sub-conjunctival
- Suprachoroidal
- Clearance
- Distribution
- Pharmacokinetic modeling
- Transport
- ENDOTHELIAL GROWTH-FACTOR
- PIGMENT EPITHELIAL-CELLS
- DIABETIC MACULAR EDEMA
- SINGLE INTRAVITREAL INJECTION
- BLOOD-AQUEOUS BARRIER
- NEONATAL FC-RECEPTOR
- HUMAN VITREOUS-HUMOR
- COMPLEMENT REGULATORY PROTEINS
- SERUM-ALBUMIN NANOPARTICLE S
- LEBERS CONGENITAL AMAUROSIS
Projects
- 1 Finished
-
Towards biological drugs for degenerative eye diseases: Delivery of heat shock protein variants to retinal pigment epithelial cells lysosomes
Casteleijn, M. G. (Project manager)
Academy of Finland, Unknown funder
01/09/2013 → 31/08/2016
Project: Research project