Phenome-wide association studies across large population cohorts support drug target validation

23andMe Res Team

doi:10.1038/s41467-018-06540-3

Phenome-wide association studies across large population cohorts support drug target validation

23andMe Res Team

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	4285
Journal	Nature Communications
Volume	9
Number of pages	13
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-018-06540-3
Publication status	Published - 16 Oct 2018
MoE publication type	A1 Journal article-refereed

Fields of Science

SYSTEMIC-LUPUS-ERYTHEMATOSUS
INFLAMMATORY-BOWEL-DISEASE
ELECTRONIC HEALTH RECORDS
WHOLE-GENOME ASSOCIATION
CORONARY-ARTERY-DISEASE
FALSE DISCOVERY RATE
BODY-MASS INDEX
GENETIC INFLUENCES
LARGE-SCALE
RISK LOCI
3111 Biomedicine
3142 Public health care science, environmental and occupational health
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1038/s41467-018-06540-3

s41467-018-06540-3Final published version, 1.49 MBLicence: CC BY

Cite this

@article{d46f5ef1be5a40d28d3d8da9ed496bf9,

title = "Phenome-wide association studies across large population cohorts support drug target validation",

keywords = "SYSTEMIC-LUPUS-ERYTHEMATOSUS, INFLAMMATORY-BOWEL-DISEASE, ELECTRONIC HEALTH RECORDS, WHOLE-GENOME ASSOCIATION, CORONARY-ARTERY-DISEASE, FALSE DISCOVERY RATE, BODY-MASS INDEX, GENETIC INFLUENCES, LARGE-SCALE, RISK LOCI, 3111 Biomedicine, 3142 Public health care science, environmental and occupational health, 3121 General medicine, internal medicine and other clinical medicine",

author = "{23andMe Res Team} and Dorothee Diogo and Chao Tian and Franklin, {Christopher S.} and Mervi Alanne-Kinnunen and Michael March and Spencer, {Chris C. A.} and Ciara Vangjeli and Weale, {Michael E.} and Hannele Mattsson and Elina Kilpel{\"a}inen and Sleiman, {Patrick M. A.} and Reilly, {Dermot F.} and Joshua McElwee and Maranville, {Joseph C.} and Chatterjee, {Arnaub K.} and Aman Bhandari and Nguyen, {Khanh-Dung H.} and Karol Estrada and Mary-Pat Reeve and Janna Hutz and Nan Bing and Sally John and MacArthur, {Daniel G.} and Veikko Salomaa and Samuli Ripatti and Hakon Hakonarson and Daly, {Mark J.} and Aarno Palotie and Hinds, {David A.} and Peter Donnelly and Fox, {Caroline S.} and Day-Williams, {Aaron G.} and Plenge, {Robert M.} and Heiko Runz",

year = "2018",

month = oct,

day = "16",

doi = "10.1038/s41467-018-06540-3",

language = "English",

volume = "9",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Phenome-wide association studies across large population cohorts support drug target validation

AU - 23andMe Res Team

AU - Diogo, Dorothee

AU - Tian, Chao

AU - Franklin, Christopher S.

AU - Alanne-Kinnunen, Mervi

AU - March, Michael

AU - Spencer, Chris C. A.

AU - Vangjeli, Ciara

AU - Weale, Michael E.

AU - Mattsson, Hannele

AU - Kilpeläinen, Elina

AU - Sleiman, Patrick M. A.

AU - Reilly, Dermot F.

AU - McElwee, Joshua

AU - Maranville, Joseph C.

AU - Chatterjee, Arnaub K.

AU - Bhandari, Aman

AU - Nguyen, Khanh-Dung H.

AU - Estrada, Karol

AU - Reeve, Mary-Pat

AU - Hutz, Janna

AU - Bing, Nan

AU - John, Sally

AU - MacArthur, Daniel G.

AU - Salomaa, Veikko

AU - Ripatti, Samuli

AU - Hakonarson, Hakon

AU - Daly, Mark J.

AU - Palotie, Aarno

AU - Hinds, David A.

AU - Donnelly, Peter

AU - Fox, Caroline S.

AU - Day-Williams, Aaron G.

AU - Plenge, Robert M.

AU - Runz, Heiko

PY - 2018/10/16

Y1 - 2018/10/16

KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS

KW - INFLAMMATORY-BOWEL-DISEASE

KW - ELECTRONIC HEALTH RECORDS

KW - WHOLE-GENOME ASSOCIATION

KW - CORONARY-ARTERY-DISEASE

KW - FALSE DISCOVERY RATE

KW - BODY-MASS INDEX

KW - GENETIC INFLUENCES

KW - LARGE-SCALE

KW - RISK LOCI

KW - 3111 Biomedicine

KW - 3142 Public health care science, environmental and occupational health

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1038/s41467-018-06540-3

DO - 10.1038/s41467-018-06540-3

M3 - Article

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

M1 - 4285

ER -