Phosphorylation of the α-chain in the integrin LFA-1 enables β2-chain phosphorylation and α-actinin binding required for cell adhesion

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Biological Chemistry
Volume293
Issue number32
Pages (from-to)12318-12330
Number of pages13
ISSN0021-9258
DOIs
Publication statusPublished - 10 Aug 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • integrin
  • phosphorylation
  • leukocyte
  • adhesion
  • talin
  • 14-3-3 protein
  • filamin
  • alpha-actinin
  • FUNCTION-ASSOCIATED ANTIGEN-1
  • INSIDE-OUT ACTIVATION
  • CYTOPLASMIC DOMAIN
  • LEUKOCYTE ADHESION
  • LIGAND-BINDING
  • THREONINE PHOSPHORYLATION
  • T-LYMPHOCYTES
  • BETA-SUBUNIT
  • CD18
  • AFFINITY
  • 1182 Biochemistry, cell and molecular biology

Cite this

@article{619c289d865a45ff83b6883462fd9c2f,
title = "Phosphorylation of the α-chain in the integrin LFA-1 enables β2-chain phosphorylation and α-actinin binding required for cell adhesion",
keywords = "integrin, phosphorylation, leukocyte, adhesion, talin, 14-3-3 protein, filamin, alpha-actinin, FUNCTION-ASSOCIATED ANTIGEN-1, INSIDE-OUT ACTIVATION, CYTOPLASMIC DOMAIN, LEUKOCYTE ADHESION, LIGAND-BINDING, THREONINE PHOSPHORYLATION, T-LYMPHOCYTES, BETA-SUBUNIT, CD18, AFFINITY, 1182 Biochemistry, cell and molecular biology",
author = "Farhana Jahan and Sudarrshan Madhavan and Taisia Rolova and Larisa Viazmina and Mikaela Gr{\"o}nholm and Gahmberg, {Carl G.}",
year = "2018",
month = "8",
day = "10",
doi = "10.1074/jbc.RA118.004318",
language = "English",
volume = "293",
pages = "12318--12330",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology",
number = "32",

}

TY - JOUR

T1 - Phosphorylation of the α-chain in the integrin LFA-1 enables β2-chain phosphorylation and α-actinin binding required for cell adhesion

AU - Jahan, Farhana

AU - Madhavan, Sudarrshan

AU - Rolova, Taisia

AU - Viazmina, Larisa

AU - Grönholm, Mikaela

AU - Gahmberg, Carl G.

PY - 2018/8/10

Y1 - 2018/8/10

KW - integrin

KW - phosphorylation

KW - leukocyte

KW - adhesion

KW - talin

KW - 14-3-3 protein

KW - filamin

KW - alpha-actinin

KW - FUNCTION-ASSOCIATED ANTIGEN-1

KW - INSIDE-OUT ACTIVATION

KW - CYTOPLASMIC DOMAIN

KW - LEUKOCYTE ADHESION

KW - LIGAND-BINDING

KW - THREONINE PHOSPHORYLATION

KW - T-LYMPHOCYTES

KW - BETA-SUBUNIT

KW - CD18

KW - AFFINITY

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1074/jbc.RA118.004318

DO - 10.1074/jbc.RA118.004318

M3 - Article

VL - 293

SP - 12318

EP - 12330

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 32

ER -