Abstract

Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear. Hence, we examined whether alterations in the morphology of 88 term placentas were associated with maternal depressive symptoms during pregnancy and psychiatric problems in 1.9-3.1-years old (Mean = 2.1 years) toddlers. Maternal depressive symptoms were rated biweekly during pregnancy with the Center of Epidemiological Studies Depression Scale (n = 86). Toddler psychiatric problems were mother-rated with the Child Behavior Checklist (n = 60). We found that higher maternal depressive symptoms throughout pregnancy [B = -0.24 Standard Deviation (SD) units: 95% Confidence Interval (CI) = -0.46; -0.03: P = 0.03; Mean difference = -0.66 SDs; 95% CI = -0.08; -1.23: P = 0.03; between those with and without clinically relevant depressive symptoms] were associated with lower variability in the placental villous barrier thickness of γ-smooth muscle actin-negative villi. This placental morphological change predicted higher total (B = -0.34 SDs: 95% CI = -0.60; -0.07: P = 0.01) and internalizing (B = -0.32 SDs: 95% CI = -0.56; -0.08: P = 0.01) psychiatric problems in toddlers. To conclude, our findings suggest that both maternal depressive symptoms during pregnancy and toddler psychiatric problems may be associated with lower variability in the villous membrane thickness of peripheral villi in term placentas. This lower heterogeneity may compromise materno-fetal exchange, suggesting a possible role for altered placental morphology in the fetal programming of mental disorders.
Original languageEnglish
Article number791
JournalScientific Reports
Volume8
Issue number1
Number of pages12
ISSN2045-2322
DOIs
Publication statusPublished - 15 Jan 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 515 Psychology
  • 3123 Gynaecology and paediatrics
  • 3111 Biomedicine
  • PERINATAL DEPRESSION
  • VILLOUS MEMBRANE
  • CHILD OUTCOMES
  • STRESS
  • RELIABILITY
  • RESTRICTION
  • EXPRESSION
  • DISORDERS
  • THICKNESS
  • VALIDITY

Cite this

@article{45c79fe907584dd99ed907e59cd3bd26,
title = "Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems.",
abstract = "Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear. Hence, we examined whether alterations in the morphology of 88 term placentas were associated with maternal depressive symptoms during pregnancy and psychiatric problems in 1.9-3.1-years old (Mean = 2.1 years) toddlers. Maternal depressive symptoms were rated biweekly during pregnancy with the Center of Epidemiological Studies Depression Scale (n = 86). Toddler psychiatric problems were mother-rated with the Child Behavior Checklist (n = 60). We found that higher maternal depressive symptoms throughout pregnancy [B = -0.24 Standard Deviation (SD) units: 95{\%} Confidence Interval (CI) = -0.46; -0.03: P = 0.03; Mean difference = -0.66 SDs; 95{\%} CI = -0.08; -1.23: P = 0.03; between those with and without clinically relevant depressive symptoms] were associated with lower variability in the placental villous barrier thickness of γ-smooth muscle actin-negative villi. This placental morphological change predicted higher total (B = -0.34 SDs: 95{\%} CI = -0.60; -0.07: P = 0.01) and internalizing (B = -0.32 SDs: 95{\%} CI = -0.56; -0.08: P = 0.01) psychiatric problems in toddlers. To conclude, our findings suggest that both maternal depressive symptoms during pregnancy and toddler psychiatric problems may be associated with lower variability in the villous membrane thickness of peripheral villi in term placentas. This lower heterogeneity may compromise materno-fetal exchange, suggesting a possible role for altered placental morphology in the fetal programming of mental disorders.",
keywords = "515 Psychology, 3123 Gynaecology and paediatrics, 3111 Biomedicine, PERINATAL DEPRESSION, VILLOUS MEMBRANE, CHILD OUTCOMES, STRESS, RELIABILITY, RESTRICTION, EXPRESSION, DISORDERS, THICKNESS, VALIDITY",
author = "Marius Lahti-Pulkkinen and Melissa Cudmore and Eva Haeussner and Christoph Schmitz and Anu-Katriina Pesonen and Esa H{\"a}m{\"a}l{\"a}inen and Villa, {Pia Maria} and Susanna Meht{\"a}l{\"a} and Eero Kajantie and Hannele Laivuori and Reynolds, {Rebecca M.} and Hans-Georg Frank and Katri R{\"a}ikk{\"o}nen",
year = "2018",
month = "1",
day = "15",
doi = "10.1038/s41598-017-19133-9",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems. / Lahti-Pulkkinen, Marius; Cudmore, Melissa; Haeussner, Eva; Schmitz, Christoph; Pesonen, Anu-Katriina; Hämäläinen, Esa; Villa, Pia Maria; Mehtälä, Susanna; Kajantie, Eero; Laivuori, Hannele; Reynolds, Rebecca M.; Frank, Hans-Georg; Räikkönen, Katri.

In: Scientific Reports, Vol. 8, No. 1, 791, 15.01.2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems.

AU - Lahti-Pulkkinen, Marius

AU - Cudmore, Melissa

AU - Haeussner, Eva

AU - Schmitz, Christoph

AU - Pesonen, Anu-Katriina

AU - Hämäläinen, Esa

AU - Villa, Pia Maria

AU - Mehtälä, Susanna

AU - Kajantie, Eero

AU - Laivuori, Hannele

AU - Reynolds, Rebecca M.

AU - Frank, Hans-Georg

AU - Räikkönen, Katri

PY - 2018/1/15

Y1 - 2018/1/15

N2 - Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear. Hence, we examined whether alterations in the morphology of 88 term placentas were associated with maternal depressive symptoms during pregnancy and psychiatric problems in 1.9-3.1-years old (Mean = 2.1 years) toddlers. Maternal depressive symptoms were rated biweekly during pregnancy with the Center of Epidemiological Studies Depression Scale (n = 86). Toddler psychiatric problems were mother-rated with the Child Behavior Checklist (n = 60). We found that higher maternal depressive symptoms throughout pregnancy [B = -0.24 Standard Deviation (SD) units: 95% Confidence Interval (CI) = -0.46; -0.03: P = 0.03; Mean difference = -0.66 SDs; 95% CI = -0.08; -1.23: P = 0.03; between those with and without clinically relevant depressive symptoms] were associated with lower variability in the placental villous barrier thickness of γ-smooth muscle actin-negative villi. This placental morphological change predicted higher total (B = -0.34 SDs: 95% CI = -0.60; -0.07: P = 0.01) and internalizing (B = -0.32 SDs: 95% CI = -0.56; -0.08: P = 0.01) psychiatric problems in toddlers. To conclude, our findings suggest that both maternal depressive symptoms during pregnancy and toddler psychiatric problems may be associated with lower variability in the villous membrane thickness of peripheral villi in term placentas. This lower heterogeneity may compromise materno-fetal exchange, suggesting a possible role for altered placental morphology in the fetal programming of mental disorders.

AB - Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear. Hence, we examined whether alterations in the morphology of 88 term placentas were associated with maternal depressive symptoms during pregnancy and psychiatric problems in 1.9-3.1-years old (Mean = 2.1 years) toddlers. Maternal depressive symptoms were rated biweekly during pregnancy with the Center of Epidemiological Studies Depression Scale (n = 86). Toddler psychiatric problems were mother-rated with the Child Behavior Checklist (n = 60). We found that higher maternal depressive symptoms throughout pregnancy [B = -0.24 Standard Deviation (SD) units: 95% Confidence Interval (CI) = -0.46; -0.03: P = 0.03; Mean difference = -0.66 SDs; 95% CI = -0.08; -1.23: P = 0.03; between those with and without clinically relevant depressive symptoms] were associated with lower variability in the placental villous barrier thickness of γ-smooth muscle actin-negative villi. This placental morphological change predicted higher total (B = -0.34 SDs: 95% CI = -0.60; -0.07: P = 0.01) and internalizing (B = -0.32 SDs: 95% CI = -0.56; -0.08: P = 0.01) psychiatric problems in toddlers. To conclude, our findings suggest that both maternal depressive symptoms during pregnancy and toddler psychiatric problems may be associated with lower variability in the villous membrane thickness of peripheral villi in term placentas. This lower heterogeneity may compromise materno-fetal exchange, suggesting a possible role for altered placental morphology in the fetal programming of mental disorders.

KW - 515 Psychology

KW - 3123 Gynaecology and paediatrics

KW - 3111 Biomedicine

KW - PERINATAL DEPRESSION

KW - VILLOUS MEMBRANE

KW - CHILD OUTCOMES

KW - STRESS

KW - RELIABILITY

KW - RESTRICTION

KW - EXPRESSION

KW - DISORDERS

KW - THICKNESS

KW - VALIDITY

U2 - 10.1038/s41598-017-19133-9

DO - 10.1038/s41598-017-19133-9

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 791

ER -